Cardiac Biomarker Release after Endurance Exercise in Male and Female Adults and Adolescents

Legaz-Arrese, Alejandro; García, Luis Enrique Carranza; Orocio, Ricardo Navarro; Valadez-Lira, Alberto; Mayolas-Pi, Carmen; Munguía‐Izquierdo, Diego; Reverter-Masià, Joaquín; George, Keith

doi:10.1016/j.jpeds.2017.08.061

Cited by 27 publications

(87 citation statements)

References 32 publications

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“…Fourteen studies met the inclusion/exclusion criteria that included 21 groups covering a total sample of 336 9 participants (72 females) who had a mean age of 15.1 ± 2.3 years (12,13,49,(76)(77)(78)20,27,30,38,39,(46)(47)(48). Two studies provided complete data from more than one subgroups contributing with different estimates by sex (27,78) or Tanner stage (30), which were treated as different units for the analysis. One study provided four outcome measurements from the same group at different exposures (12), which were controlled for multiplicity within the models (51,81).…”

Section: Resultsmentioning

confidence: 99%

“…Based on studies with adult participants other individual characteristics, other than age, might influence cardiac biomarkers release. Sex differences in cTn and NT-proBNP are controversial (4,6,10,23,30,36,56,80). Previous exercise experience has been negatively associated with cTn release (10,21,47,76) while training load might be not associated with biomarker appearance (18,21,28,33,68,79).…”

Section: Introductionmentioning

confidence: 99%

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Cardiac Biomarker Release After Exercise in Healthy Children and Adolescents: A Systematic Review and Meta-Analysis

Cirer-Sastre

Legaz-Arrese

Corbi

et al. 2019

Pediatric Exercise Science

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Purpose:The authors evaluated the impact of acute exercise and 24-hour recovery on serum concentration of cardiac troponins T and I (cTnT and cTnI) and N-terminal fragment of the prohormone brain natriuretic peptide (NT-proBNP) in healthy children and adolescents. The authors also determined the proportion of participants exceeding the upper reference limits and acute myocardial infarction cutoff for each assay.Method:Web of Science, SPORTDiscus, MEDLINE, ScienceDirect, and Scopus databases were systematically searched up to November 2017. Studies were screened and quality-assessed; the data was systematically extracted and analyzed.Results:From 751 studies initially identified, 14 met the inclusion criteria for data extraction. All 3 biomarkers were increased significantly after exercise. A decrease from postexercise to 24 hours was noted in cTnT and cTnI, although this decrease was only statistically significant for cTnT. The upper reference limit was exceeded by 76% of participants for cTnT, a 51% for cTnI, and a 13% for NT-proBNP. Furthermore, the cutoff value for acute myocardial infarction was exceeded by 39% for cTnT and a 11% for cTnI. Postexercise peak values of cTnT were associated with duration and intensity (Q(3) = 28.3,P < .001) while NT-proBNP peak values were associated with duration (Q(2) = 11.9,P = .003).Conclusion:Exercise results in the appearance of elevated levels of cTnT, cTnI, and NT-proBNP in children and adolescents. Postexercise elevations of cTnT and NT-proBNP are associated with exercise duration and intensity.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cardiac Biomarker Release After Exercise in Healthy Children and Adolescents: A Systematic Review and Meta-Analysis

Cirer-Sastre

Legaz-Arrese

Corbi

et al. 2019

Pediatric Exercise Science

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“…Simiwww.journals.viamedica.pl/medical_research_journal larly, in some studies, higher values of cTn values have been observed from pre-and post-exercise conditions [8] due to controlled interventions during endurance training. From the literature, it is evident that in adolescent athletes, their immature cardiac muscles result in increased cTn detection after exercise [8,17,18,20]. Therefore, these data obtained are not significant for a better understanding of the cTn release mechanism.…”

Section: Introductionmentioning

confidence: 99%

“…There has also been an effort to study the different factors that affect the cTn release after physical workouts. Several research works have associated the increase in cardiac troponin I (cTnI) with exercise style [7], individual age [8], high throughput exercises, and long duration [5] and level of physical adaptation to exercise [9]. However, the results obtained in different studies do not cohere with each other.…”

Section: Introductionmentioning

confidence: 99%

“…Similarly, the data is usually obtained from activities that are field based, and post-activity sampling intervals are fewer, which shows data with inaccurate values for cTn release [19]. Simiwww.journals.viamedica.pl/medical_research_journal larly, in some studies, higher values of cTn values have been observed from pre-and post-exercise conditions [8] due to controlled interventions during endurance training. From the literature, it is evident that in adolescent athletes, their immature cardiac muscles result in increased cTn detection after exercise [8,17,18,20].…”

Section: Introductionmentioning

confidence: 99%

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Cardiac Biomarker Levels After a Football Match in Professional Versus Amateur Lithuanian Football Players

Aldujeli¹,

Briedis

Aldujeili

et al. 2019

Medical Research Journal

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Background: There are very limited scientific data available on cardiac troponin I release after intermittent exercise. To know the different factors that mediate cTnI release after exercise is of concern for scientists. In this regard, our study is based on two major goals: 1) to evaluate the cTnI release in individuals during a sports match; and 2) to understand the impact of the status of the athlete (biological) on the release of individual cTnI. Methods: A total of 44 players, including "22 adult professional [PFP]: 24.2±4.5 years, 22 adult amateur [AFP]: 26.5±3.6 years" were involved in a match simulated as real. Successive observations of cTnI release were obtained at different settings such as at rest, pre-exercise, and instant-post-exercise at regular intervals of 3, 6, and then 24 h post-exercise. Results: From the obtained results it was observed that the individual highest values were vastly varied, with higher levels of cTnI release baseline and post-exercise for PFP players as compared to those of AFP (all p < 0.05). Moreover, the cTnI levels were increased (peak post: 0.024 [0.004-0.244] μg/L; p < 0.05). Additionally, the cTnI peak values surpassed the upper limit of reference in 77.3% of PFP (17 PFP). Conclusions: Our study data results affirm that the cTnI release is highly affected by the status of athletes. The cTnI release is enhanced by intermittent exercise.

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Age-Dependent Reference Values for hs-Troponin T and NT-proBNP and Determining Factors in a Cohort of Healthy Children (The LIFE Child Study)

et al. 2022

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This study aimed to provide reliable pediatric reference values for N-terminal pro-brain natriuretic peptide (NT-proBNP) and high-sensitive Troponin T (hsTnT) obtained from a population of well children and investigate for associations with sex, pubertal status, body mass index (BMI), and serum lipid levels. We analyzed hsTnT and NT-proBNP values obtained from 4826 samples provided by 2522 children aged 0.25–18 years participating in a prospective longitudinal population-based cohort study, “LIFE child” in Leipzig, Germany (Poulain et al., Eur J Epidemiol 32:145–158, 2017). NT-proBNP values decreased throughout childhood from values over 400 ng/L at 3 months to 138 ng/L in females and 65 ng/L in males by 18 years of age. Values dropped rapidly with advancing pubertal stage. We found a strong association between lower NT-proBNP values and higher BMI or elevated serum lipids, the latter effect being more pronounced in males. For hsTnT levels, approximately half of the measurements were below the detection limit. However, 76% of those aged 3 months and 21% of those aged 6 months had values exceeding the adult cut-off limit. Females had slightly higher levels in the first 2 years of life but this was reversed during puberty. In males, there was an upward trend from pubertal stage 2 onward. We identified a positive association between hsTnT and BMI but a negative association with low-density lipoprotein (LDL) cholesterol and triglyceride levels in boys but not in girls. Based on a large number of healthy children, we have established reliable reference values for NT-proBNP and hsTnT for use in everyday clinical practice. We have also identified important associations between certain metabolic and cardiac markers.Clinical Trial Registration ClinicalTrial.gov (NCT02550236).

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Cardiac Biomarker Release after Endurance Exercise in Male and Female Adults and Adolescents

Cited by 27 publications

References 32 publications

Cardiac Biomarker Release After Exercise in Healthy Children and Adolescents: A Systematic Review and Meta-Analysis

Cardiac Biomarker Release After Exercise in Healthy Children and Adolescents: A Systematic Review and Meta-Analysis

Cardiac Biomarker Levels After a Football Match in Professional Versus Amateur Lithuanian Football Players

Age-Dependent Reference Values for hs-Troponin T and NT-proBNP and Determining Factors in a Cohort of Healthy Children (The LIFE Child Study)

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