Cardiac Biomarkers and Prediction of Early Outcome After Heart Valve Surgery: A Prospective Observational Study

Wozolek, Aaron; Jaquet, Océane; Donneau, Anne‐Françoise; Lancellotti, P; Legoff, Caroline; Cavalier, Étienne; Radermecker, Marc; Lavigne, Jean-Paul; Durieux, Rodolphe; Roediger, Laurence; Sénard, Marc; Hubert, Marie Bernard; Brichant, Jean-François; Amabili, Philippe; Hans, Grégory

doi:10.1053/j.jvca.2021.06.028

Cited by 4 publications

(1 citation statement)

References 28 publications

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“… 12 , 15 The 2017 American College of Cardiology/American Heart Association Guidelines on Heart Failure Management 16 proposed that sST2 can provide additional value on risk stratification in patients with acute decompensated heart failure (Grade IIb recommendation, Grade A evidence) and chronic heart failure (Grade IIb recommendation, Grade B evidence). A study reported that preoperative sST2 levels could predict long‐term survival after cardiac valve surgery, 17 but there are no relevant reports on the factors influencing preoperative sST2 levels in patients with VHD. In addition, whether sST2 levels are related to postoperative cardiac function improvement after surgery remains unknown.…”

Section: Introductionmentioning

confidence: 99%

Preoperative sST2 levels relate to myocardial remodeling and cardiac function improvement after cardiac valve surgery

Zhu,

Pei,

et al. 2023

ESC Heart Failure

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AimsWe aim to investigate the correlation between preoperative soluble suppression of tumourigenicity 2 (sST2) and postoperative myocardial remodelling and cardiac function in patients with valvular heart disease.Methods and resultsThis retrospective study included patients who underwent heart valve surgery at the General Hospital of Northern Theatre Command from July 2019 to June 2020. Preoperative, early postoperative, and 1‐month postoperative cardiac ultrasound data were collected. Multivariable linear regression was used to analyse the factors associated with preoperative sST2 and postoperative cardiac function parameters. A receiver operator characteristic curve analysis was used to analyse the predictive value of sST2 for left ventricular ejection fraction (LVEF) reduction at 1 month after surgery. This study included 156 patients. Left ventricular end‐systolic volume (b = 0.125, P = 0.004), atrial fibrillation (b = 7.933, P = 0.003), and coronary artery disease (b = 5.826, P = 0.043) were correlated with the preoperative sST2 levels. Preoperative sST2 was independently associated with early postoperative left ventricular end‐systolic volume (b = −0.136, P = 0.035), left ventricular end‐diastolic volume (b = −0.225, P = 0.036), and LVEF (b = 0.056, P = 0.008). At 1 month after surgery, LVEF (r = −0.234, P = 0.023) and reduction in LVEF (r = −0.316, P = 0.002) were negatively correlated with preoperative sST2. The area under the receiver operator characteristic curve of preoperative sST2 in predicting LVEF reduction at 1 month was 0.646, with a sensitivity of 0.357 and a specificity of 0.918.ConclusionsPreoperative sST2 levels are related to early postoperative myocardial remodelling and have a predictive value for the improvement of cardiac function 1 month after surgery.

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