Cardiac Biomarkers in Hyperthyroid Cats

Sangster, Jodi K; Panciera, David L.; Abbott, Jonathan A.; Zimmerman, Kelley; Lantis, Andrea C

doi:10.1111/jvim.12259

Cited by 32 publications

(28 citation statements)

References 31 publications

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“…The difference between our cutoff and that determined in a previous study might be explained by the different grading system and exclusion criteria used in our study. Because impaired renal function, hyperthyroidism, and hypertension cause increases in cTnI, we excluded such cats from our study. However, the previous study included cats with concomitant chronic kidney disease and used higher blood pressure and higher serum T4 concentration as exclusion criteria.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of a sensitive cardiac troponin I assay as a screening test for the diagnosis of hypertrophic cardiomyopathy in cats

Hertzsch

Roos

Wess

2019

Veterinary Internal Medicne

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Background Hypertrophic cardiomyopathy (HCM) is the most common cardiac disease in cats. However, most cats are not diagnosed until they develop congestive heart failure, arterial thromboembolism (ATE), or sudden cardiac death. Thus, an affordable screening test for early detection of HCM is desirable. Hypothesis/Objectives Evaluation of a sensitive cardiac troponin I (cTnI) assay as a screening test for HCM in cats and determination of a cutoff for its early detection. Animals One hundred sixty‐six client‐owned cats (male, n = 97) of various breeds were evaluated and classified using echocardiography as being healthy (n = 87), equivocal (n = 15), or having HCM (mild, n = 16; moderate, n = 10; severe, n = 34) or ATE (n = 4). Methods All cats were prospectively evaluated by echocardiography, and serum cTnI concentration was determined using the currently most sensitive assay (Siemens ADVIA Centaur TnI‐Ultra). Results The median cTnI concentration was significantly different between study groups ( P < .000001). A cutoff of 0.06 ng/mL provided good discrimination between healthy cats and cats with HCM (sensitivity, 91.7%; specificity, 95.4%; area under the curve [AUC], 0.95; 95% confidence interval [CI], 0.899‐0.978). Even for asymptomatic cats with HCM, sensitivity and specificity for a cutoff of >0.06 ng/mL remained high at 87.8% and 95.4%, respectively (AUC, 0.93; 95% CI, 0.864‐0.964). Conclusions and clinical importance Cardiac troponin I can be used as a sensitive and specific screening test for the diagnosis of HCM in otherwise healthy cats (cutoff, >0.06 ng/mL). However, echocardiography is needed to confirm the diagnosis.

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Section: Discussionmentioning

confidence: 99%

Evaluation of a sensitive cardiac troponin I assay as a screening test for the diagnosis of hypertrophic cardiomyopathy in cats

Hertzsch

Roos

Wess

2019

Veterinary Internal Medicne

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“…Furthermore, many disease processes trigger myocardial injury, even in cats without primary cardiac disease . Increased cTnI concentrations have been reported in animals with systemic inflammatory disease, trauma, and hyperthyroidism . Such possible confounders should be considered when measuring cTnI concentrations in cats.…”

Section: Discussionmentioning

confidence: 99%

“…36,37 Increased cTnI concentrations have been reported in animals with systemic inflammatory disease, trauma, and hyperthyroidism. [36][37][38][39] Such possible confounders should be considered when measuring cTnI concentrations in cats.…”

Section: Journal Of Veterinary Internal Medicinementioning

confidence: 99%

Diagnostic utility of cardiac troponin I in cats with hypertrophic cardiomyopathy

Hori

Iguchi²,

Heishima

et al. 2018

Veterinary Internal Medicne

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BackgroundCardiac troponin I (cTnI) is useful for assessing hypertrophic cardiomyopathy (HCM) in cats.ObjectiveTo measure plasma cTnI concentrations in healthy cats and evaluate the clinical utility of cTnI in determining the severity of HCM.AnimalsClinically healthy cats (n = 88) and cats with HCM (n = 93).MethodsMulticenter prospective study. Cats with HCM, including hypertrophic obstructive cardiomyopathy at various stages, were diagnosed using echocardiography. Plasma cTnI concentrations were analyzed by a commercial laboratory. Receiver‐operating characteristic curve analysis was used to evaluate the accuracy of plasma cTnI concentrations to detect HCM.ResultsThe median cTnI concentration was 0.027 ng/mL (interquartile range, 0.012‐0.048 ng/mL) in healthy cats. Concentrations were significantly higher in diseased cats than in healthy controls, and concentrations were significantly higher in cats with heart failure than in asymptomatic cats. A plasma cTnI concentration of 0.163 ng/mL had a sensitivity of 62.0% and specificity of 100% when used to distinguish normal cats from asymptomatic HCM cats without left atrial dilatation. A cutoff of 0.234 ng/mL had high sensitivity (95.0%) and specificity (77.8%) for assessing heart failure. The areas under the receiver‐operating characteristic curves were 0.85 and 0.93, respectively.Conclusions and Clinical ImportanceIncreased cTnI concentrations reflect the severity of HCM. If other causes of cardiac injury are ruled out, plasma cTnI concentration may be useful for predicting the severity of HCM in cats.

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“…30,31 Similar findings have been observed in several animal species with noncardiac diseases, in which high serum cTnI concentration has been associated with short-and long-term mortality rates. 19,26,[32][33][34][35][36][37][38] The usefulness of cTnI as a potential marker for systemic disease and its association with outcome has not yet been investigated in seals, and such information could be valuable for predicting whether injured or diseased pups might be successfully rehabilitated. The objective of the study reported here was to investigate changes in serum cTnI concentration in harbor seal pups at different points during rehabilitation and to test whether serum cTnI concentrations were associated with survival during rehabilitation or duration of rehabilitation.…”

Section: Abbreviations Ctnimentioning

confidence: 99%

Usefulness of serum cardiac troponin I concentration as a marker of survival of harbor seal (Phoca vitulina) pups during rehabilitation

Fonfara¹,

Sundermeyer²,

Casamian‐Sorrosal³

et al. 2016

javma

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OBJECTIVE To measure serum cardiac troponin I (cTnI) concentrations in orphaned harbor seal (Phoca vitulina) pups at various points during rehabilitation in a seal rescue center and determine whether cTnI concentration was associated with survival during rehabilitation and duration of rehabilitation. DESIGN Serial cross-sectional study. ANIMALS Fifty-five 2- to 9-day-old harbor seal pups. PROCEDURES Blood samples for serum cTnI concentration measurement, CBC, and serum biochemical analysis were obtained from seal pups at admission into a seal rescue center, after 2 weeks of rehabilitation at the center, and prior to release. Serum cTnI concentrations were compared between seals that did or did not survive rehabilitation. RESULTS Median serum cTnI concentration was highest at admission (0.03 ng/mL). After 2 weeks, the median value was 0.01 ng/mL; prior to release, it was 0.01 ng/mL. Seal pups that were found to have died during or after rehabilitation (n = 7) had a significantly higher median serum cTnI concentration at admission (0.06 ng/mL) than did seal pups that survived rehabilitation (and for which the postrelease fate was unknown; 48; 0.03 ng/mL). No correlation was identified between serum cTnI concentration and duration of rehabilitation. CONCLUSIONS AND CLINICAL RELEVANCE The results of this study suggested some degree of myocardial injury was present in most of the orphaned seal pups admitted for rehabilitation. Measurement of serum cTnI concentration in seal pups at admission might provide prognostic information about their likelihood of survival during or after rehabilitation.

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Cardiac Biomarkers in Hyperthyroid Cats

Cited by 32 publications

References 31 publications

Evaluation of a sensitive cardiac troponin I assay as a screening test for the diagnosis of hypertrophic cardiomyopathy in cats

Evaluation of a sensitive cardiac troponin I assay as a screening test for the diagnosis of hypertrophic cardiomyopathy in cats

Diagnostic utility of cardiac troponin I in cats with hypertrophic cardiomyopathy

Usefulness of serum cardiac troponin I concentration as a marker of survival of harbor seal (Phoca vitulina) pups during rehabilitation

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