Cardiac biopsy in childhood.

MacKay, E H; Pickering, D; Littler, W. A.

doi:10.1136/adc.52.10.785

Cited by 11 publications

(2 citation statements)

References 11 publications

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“…The technique of percutaneous EMB in childhood has also received attention from a fairly small number of workers. Mackay et a1 [65] in England were the first to document this procedure in childhood in the English literature. The age range of their group of patients was five months to 15 years and they were successful in obtaining specimens in 82% of their cases, with an overall low risk rate.…”

Section: Percutaneous Trans-catheter Endomyocardial Biopsy Techniquementioning

confidence: 99%

“…Much confusion exists in the literature with respect to the term "endocardial fibroelastosis," which in its pure form should be confined to infants who only have a diastolic ventricular dysfunction in the absence of any true myocardial involvement. This group of patients has endocardial fibrosis with elastic laminae, which can easily be diagnosed by EMB [65,67,68]. It has been accepted that this group can be subdivided into two subgroups, one without any associated congenital cardiac defects, and the other with concomitant aortic atresia, ventricular septa1 defect, left-sided hypoplasia, and anomalous coronary arteries.…”

Section: Endocardial Fibroelastosis (Efe)mentioning

confidence: 99%

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Endomyocardial biopsy: A review of the literature

Przybojewski

1985

Cathet. Cardiovasc. Diagn.

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A review of the literature relating to endomyocardial biopsy (EMB) is presented. This is considered important at this time since EMB is being utilized with increasing frequency, particularly for the diagnosis of myocarditis. The development of the technique is briefly outlined. Emphasis is placed on the clinical application of EMB in the various primary cardiomyopathies (dilated, hypertrophic, restrictive, and obliterative), the infiltrative secondary cardiomyopathies (amyloidosis, sarcoidosis, hemochromatosis), myocarditis, as well as such conditions as adriamycin cardiotoxicity, cardiac transplant rejection, and Kawasaki disease. More controversial application of EMB in primary mitral valve prolapse (Barlow's syndrome), idiopathic ventricular arrhythmias, and the elucidation of the enigmatic finding of angina with angiographically normal coronary arteries is detailed. Experience with immunological and biochemical investigation of biopsy material, as well as with virus isolation and drug assays in the myocardium, is alluded to. Complications encountered with this procedure are also discussed, and its future role is contemplated.

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Section: Percutaneous Trans-catheter Endomyocardial Biopsy Techniquementioning

confidence: 99%

Section: Endocardial Fibroelastosis (Efe)mentioning

confidence: 99%

Endomyocardial biopsy: A review of the literature

Przybojewski

1985

Cathet. Cardiovasc. Diagn.

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Endomyocardial biopsy in infants and children with cardiomyopathy

Narayan

Menahem

Chow

et al. 1991

Clinical Cardiology

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We reviewed our experience of endomyocardial biopsy performed on 21 symptomatic infants and children with cardiomyopathy. Clinical congestive cardiomyopathy was noted in 18 patients, 2 had hypertrophic cardiomyopathy, and 1 a restrictive cardiomyopathy. The biopsy findings led to a diagnosis of hemiochromatosis in one patient, Adriamycin cardiomyopathy in another, and lymphocytic myocarditis in a third. Five patients had features of endocardial fibroelastosis, one endomyocardial fibrosis, and a further one, a mitochrondrial abnormality. In 11 patients normal or nonspecific features were seen. There were 2 myocardial perforations, both patients being successfully resuscitated. Endomyocardial biopsy, although occasionally hazardous, may sometimes provide valuable information which may lead to a diagnosis, facilitate treatment, and be of prognostic value. Despite the low positive yield, it may still be indicated in selected patients, in view of the seriousness and often poor prognosis of this disorder: 5 of our study group subsequently died.

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Endomyocardial biopsy in infants and children: Technique; indications and results

1982

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By modification of a miniaturized technique for transcatheter endomyocardial biopsy, it was possible to insert a bioptome through a 6 French catheter in 15 infants and children aged 40 days to 17 years and weighing 3.5 to 55kg. Eight right and 7 left ventricular biopsies were performed, and the specimens were examined by light and electron microscopy. In one child we failed to obtain a specimen. There were no complications. Diagnoses to be either proved or excluded were hypertrophic or dilated cardiomyopathy, endocardial fibroelastosis, glycogen and lipid storage disease, tumours and myocarditis. Morphological examination was diagnostic in 2 cases, helpful in 10 cases and of no help in 2 cases. by this technique it is possible to prove endomyocardial diseases with a high degree of reliability in infants and children without increasing risk or stress.

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Cardiac biopsy in childhood.

Cited by 11 publications

References 11 publications

Endomyocardial biopsy: A review of the literature

Endomyocardial biopsy: A review of the literature

Endomyocardial biopsy in infants and children with cardiomyopathy

Endomyocardial biopsy in infants and children: Technique; indications and results

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