“…However, this treatment can be associated with considerable side effects such as pulmonary overflow, haemodynamic instability with low diastolic blood pressure, increased vulnerability for renal failure, sepsis, and necrotizing enterocolitis. Other common side effects include apnea, hyperthermia, diarrhea, skin flushing, edema, and cortical hyperostosis [5,8,9]. Prostaglandin E1infusion may only result in incomplete ductal reopening and partial istmal relaxation, leaving insufficient systemic flow for a prolonged time [10].…”