Cardiac cell senescence: molecular mechanisms, key proteins and therapeutic targets

Abstract

Cardiac aging, particularly cardiac cell senescence, is a natural process that occurs as we age. Heart function gradually declines in old age, leading to continuous heart failure, even in people without a prior history of heart disease. To address this issue and improve cardiac cell function, it is crucial to investigate the molecular mechanisms underlying cardiac senescence. This review summarizes the main mechanisms and key proteins involved in cardiac cell senescence. This review further discusses the molecular modulators of cellular senescence in aging hearts. Furthermore, the discussion will encompass comprehensive descriptions of the key drugs, modes of action and potential targets for intervention in cardiac senescence. By offering a fresh perspective and comprehensive insights into the molecular mechanisms of cardiac senescence, this review seeks to provide a fresh perspective and important theoretical foundations for the development of drugs targeting this condition.

Optical redox imaging to screen synthetic hydrogels for stem cell-derived cardiomyocyte differentiation and maturation

“…The protocol is expected to produce a relatively pure CM population 3 and observed metabolic changes dominated by the differentiation process in iPSC-CMs 46 rather than proliferation or senescence. [69][70][71] We found that ORI can detect increased oxidative activity during early maturation (decreased ORR over time) and separates cells by differentiation efficiency. Furthermore, we demonstrated the ability to perform extended culture and repeated ORI on synthetic hydrogels.…”