Cardiac Chamber Volumes, Function, and Mass as Determined by 64-Multidetector Row Computed Tomography

Lin, Fay Y.; Devereux, Richard B.; Roman, Mary J.; Meng, Joyce; Jow, Veronica M.; Jacobs, Avrum; Weinsaft, Jonathan W.; Shaw, Leslee J.; Berman, Daniel S.; Callister, Tracy Q.; Min, James K.

doi:10.1016/j.jcmg.2008.04.015

Cited by 161 publications

(88 citation statements)

References 5 publications

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“…Until recently, even a reference value had not been established for RA size. 22 As revealed in the current investigation, RA volume and LA size were more increased in patients with PeAF than in subjects with PaAF. Thus, it can be said that the severity of RA anatomical remodeling, along with LA enlargement, is correlated with the chronicity of AF.…”

Section: Atrial Anatomical Remodeling In Afsupporting

confidence: 67%

Right Atrial Anatomical Remodeling Affects Early Outcomes of Nonvalvular Atrial Fibrillation After Radiofrequency Ablation

Moon

Hong

Shim

et al. 2012

Circ J

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Section: Atrial Anatomical Remodeling In Afsupporting

confidence: 67%

Right Atrial Anatomical Remodeling Affects Early Outcomes of Nonvalvular Atrial Fibrillation After Radiofrequency Ablation

Moon

Hong

Shim

et al. 2012

Circ J

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“…11,23,24 LVEF was calculated using end-diastole and end-systole volumes and LVEF Ͻ50% was considered abnormal. 11,25 Patient Follow-Up Patient follow-up for all-cause mortality was performed by each local institution by telephone interview, with validation of reported death through medical records whenever possible and/or a national death registry.…”

Section: Clinical Predictorsmentioning

confidence: 99%

Incremental Prognostic Value of Cardiac Computed Tomography in Coronary Artery Disease Using CONFIRM

Chow

Small

Yam

et al. 2011

Circ: Cardiovascular Imaging

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206

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on behalf/for the CONFIRM Investigators Background-Large multicenter studies validating the prognostic value of coronary computed tomographic angiography (CCTA) and left ventricular ejection fraction (LVEF) are lacking. We sought to confirm the independent and incremental prognostic value of coronary artery disease (CAD) severity measured using 64-slice CCTA over LVEF and clinical variables. Methods and Results-A large international multicenter registry (CONFIRM Registry) was queried, and CCTA patients with LVEF data on CCTA were screened. Patients with a history of myocardial infarction, coronary revascularization, or cardiac transplantation were excluded. The National Cholesterol Education Program-Adult Treatment Panel III risk was calculated for each patient, and CCTA was evaluated for CAD severity (normal, nonobstructive, non-high-risk, or high-risk CAD) and LVEF Ͻ50%. Patients were followed for an end point of all-cause mortality; 27 125 patients underwent CCTA at 12 participating centers, with a total of 14 064 patients meeting the analysis criteria. Follow-up was available for 13 966 (99.3%) patients (mean follow-up of 22.5 months; 95% confidence interval, 22.3 to 22.7 months). All-cause mortality (271 deaths) occurred in 0.65% of patients without coronary atherosclerosis, 1.99% of patients with nonobstructive CAD, 2.90% of patients with non-high-risk CAD, and 4.95% for patients with high-risk CAD. Multivariable analysis confirmed that LVEF Ͻ50% (hazard ratio, 2.74; 95% confidence interval, 2.12 to 3.51) and CAD severity (hazard ratio,1.58; 95% confidence interval, 1.42 to 1.76) were predictors of all-cause mortality, and CAD severity had incremental value over LVEF and clinical variables. Conclusions-Our results demonstrate that CCTA measures of CAD severity and LVEF have independent prognostic value. Incorporation of CAD severity provides incremental value for predicting all-cause death over routine clinical predictors and LVEF in patients with suspected obstructive CAD. (Circ Cardiovasc Imaging. 2011;4:463-472.)

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“…Indeed, inconsistent data derived from small populations have been reported, indicating that LVEF decreases or remains unchanged with age and is not influenced by gender. 7,8 Knowledge of these parameters, however, is crucial in order to stratify risk and guide therapy of patients with CAD. Thus, given the prognostic importance of LV function and its routine use in clinical decision making, the aim of this study was to assess age-and gender-specific changes of LV dimensions and systolic function by 64-slice cardiac CT in a large international multicenter cohort.…”

Section: Introductionmentioning

confidence: 99%

Impact of age and sex on left ventricular function determined by coronary computed tomographic angiography: results from the prospective multicentre CONFIRM study

Gebhard

Buechel

Stähli

et al. 2016

European Heart Journal - Cardiovascular Imaging

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BackgroundLeft ventricular (LV) volumetric and functional parameters measured with cardiac computed tomography (cardiac CT) augment risk prediction and discrimination for future mortality. Gender-and age-specific standard values for LV dimensions and systolic function obtained by 64-slice cardiac CT are lacking. Methods and results1155 patients from the Coronary CT Angiography EvaluatioN For Clinical Outcomes: An InteRnational Multicenter registry (54.5% males, mean age 53.1 + 12.4 years, range: 18 -92 years) without known coronary artery disease (CAD), structural heart disease, diabetes, or hypertension who underwent cardiac CT for various indications were categorized according to age and sex. A cardiac CT data acquisition protocol was used that allowed volumetric measuring of LV function. Image interpretation was performed at each site. Patients with significant CAD (.50% stenosis) on cardiac CT were excluded from the analysis. Overall, mean left ventricular ejection fraction (LVEF) was higher in women when compared with men (66.6 + 7.7% vs. 64.6 + 8.1%, P , 0.001). This gender-difference in overall LVEF was caused by a significantly higher LVEF in women ≥70 years when compared with men ≥70 years (69.95 + 8.89% vs. 65.50 + 9.42%, P ¼ 0.004). Accordingly, a significant increase in LVEF was observed with age (P ¼ 0.005 for males and P , 0.001 for females), which was more pronounced in females (5.21%) than in males

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Cardiac Chamber Volumes, Function, and Mass as Determined by 64-Multidetector Row Computed Tomography

Abstract: This study establishes age- and gender-specific values for LV, RV, LA, and RA size, function, and mass in adults free of cardiovascular disease, hypertension, and obesity using 1D, 2D, and 3D methods. These data can be used as a reference for future MDCT studies.

Cited by 161 publications

References 5 publications

Right Atrial Anatomical Remodeling Affects Early Outcomes of Nonvalvular Atrial Fibrillation After Radiofrequency Ablation

Right Atrial Anatomical Remodeling Affects Early Outcomes of Nonvalvular Atrial Fibrillation After Radiofrequency Ablation

Incremental Prognostic Value of Cardiac Computed Tomography in Coronary Artery Disease Using CONFIRM

Impact of age and sex on left ventricular function determined by coronary computed tomographic angiography: results from the prospective multicentre CONFIRM study

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