Cardiac changes in epileptic baboons with high-frequency microburst VNS therapy: A pilot study

Garza, Melissa A. de la; Poldiak, David; Shade, Robert E.; Salinas, F.; Papanastassiou, Alex M.; Szabó, C. Ákos

doi:10.1016/j.eplepsyres.2019.106156

Cited by 6 publications

(3 citation statements)

References 15 publications

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“…de la Garza et al 18 in 2019 published a study with objective to evaluate autonomic differences, including heart rate (HR), heart rate variability (HRV) and corrected QT-duration (QTc) between two epileptic (EB1, EB2) and one control (CB) baboon. They came up with the conclusion that heart rate and QTc interval was altered in cases of epilepsy as compared to controls and that might be one of the reasons for sudden unexplained death in these patients.…”

Section: Outmentioning

confidence: 99%

Cardiac biomarkers in patients with epilepsy.

Hanif¹,

Siddiq²,

Zaib³

et al. 2021

TPMJ

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Objective: To determine the frequency of deranged cardiac biomarkers and associated socio-demographic factors among patients of epilepsy presenting at our hospital. Study Design: Cross-sectional study. Setting: Department of Medicine, Sheikh Khalifa Bin Zyed Al-Nyhan Hospital Rawalakot. Period: August 2019 to September 2020. Material & Methods: We evaluated 85 consecutive patients who presented at Department of Medicine, Sheikh Khalifa Bin Zyed Al-Nyhan hospital. Cardiac Biomarkers (Troponin I, CK-MB and pro-BNP) and EKG were requested in all patients. The questionnaire used for interview consisted of demographic details and disease related parameters (duration of epilepsy and number of antiepileptic drugs). Results: Out of 85 patients included in the study, 35 (41.2%) were male while 45 (58.8%) were female. Out of these 85 patients of epilepsy, 15 (17.6%) had one or more cardiac biomarker positive while 70 (82.4%) had no change in ECG or any positive cardiac biomarker. All ECG changes were non-specific. After applying the logistic regression, we found that long duration of illness and poly-pharmacy had significant association with the presence of positive cardiac biomarkers among the patients of epilepsy. Conclusion: Less than 1/5th of the patients with epilepsy had positive cardiac biomarkers or ECG changes in our study. Patients with longer duration of epilepsy or those whose epilepsy has been managed with more than one drug were found more at risk of having abnormal cardiac biomarkers in our target population.

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Section: Outmentioning

confidence: 99%

Cardiac biomarkers in patients with epilepsy.

Hanif¹,

Siddiq²,

Zaib³

et al. 2021

TPMJ

View full text Add to dashboard Cite

show abstract

“…Recent reports indicate the value of canines, rabbits, and primates for SUDEP research and neurotherapeutics. [59][60][61][62][63] Interestingly, like humans, epileptic baboons exhibit cardiac ECG and autonomic abnormalities, 61,62 and they better reproduce human cardiac electrical function. 57,64 Additionally, the field is closing in on developing precision medicine to treat genetic epilepsies, which requires the identification of rigorous preclinical animal models with reproducible phenotypes relevant to humans.…”

mentioning

confidence: 99%

“…As mice do not fully recapitulate human neurocardiac function, 57,58 there is a need for new translational models of SUDEP. Recent reports indicate the value of canines, rabbits, and primates for SUDEP research and neurotherapeutics 59–63 . Interestingly, like humans, epileptic baboons exhibit cardiac ECG and autonomic abnormalities, 61,62 and they better reproduce human cardiac electrical function 57,64 .…”

mentioning

confidence: 99%