Cardiac changes in patients with chronic liver disease: A prospective descriptive study

Sukhwani, Nitesh; Nayak, Om Prakash; Kumbhkar, Tapas

doi:10.17511/ijmrr.2016.i04.16

Cited by 3 publications

(3 citation statements)

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“…7 Our study showed higher incidence of alcoholism as cause of cirrhosis (64%) followed by idiopathic (18%) causes and HBsAg (12%) is third commonest cause. which is consistent with study done by Sukhwani et al and Punekar et al 7,8 HBsAg and Idiopathic causes are 12 and 18% respectively in our study, which is consistent with study done by Punekar et al 7 Higher incidence of alcoholic liver disease can be attributed increased malnutrition in Indian population and higher susceptibility of liver to alcohol induced damage in Indian population.…”

Section: Agesupporting

confidence: 93%

“…Values correlated with studies done by Punekar, Sukhwani, Selvamani et al 7,8,10 Higher incidence of anemia and hypoprotienemia can be due to preexisting anemia and malnutrition in Indian population, which is supported by other Indian studies. 7,8,10 In our study 38% had pleural effusion, 32% of cases had diastolic dysfunction. Also, 11% of cases had grade 2 diastolic dysfunction.…”

Section: Agesupporting

confidence: 85%

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Study of cardiac involvement in liver cirrhosis patients

et al. 2021

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Background: Cirrhosis liver is characterized by diffuse destruction and regeneration of hepatic parenchymal cells. Various studies have been carried out over the years to evaluate the cardiac and hemodynamic changes in cirrhosis of the liver.Methods: Study is conducted on 50 consecutive patients with cirrhosis liver admitted in various medical wards of the Mc Gann Hospital attached to Shimoga institute of medical sciences, Shimoga from January, 2020 to September 2020. Detailed history was taken and a through physical examination was done. Blood investigations are done. Echocardiography, Chest radiography done. All patients were subjected to USG abdomen to confirm the diagnosis of cirrhosis.Results: There were 35 males and 15 females. Average age is 54±6.6 years. Alcoholism (64%) and idiopathic (16%) are commonest associations. Commonest symptom is anaemia (88%) followed by pedal oedema (80%) followed by fatigue (66%), ascites (60%) and jaundice (60%). Pleural effusion seen in 38%, diastolic dysfunction 32%, pericardial effusion 16%, wall motion abnormality in 11%. Hypertension, arrhythmias and LVF is seen in 8%. Cardiomyopathy in 6%. ECG changes are Hemiblock in 4 (8%), QTc prolongation in 34%. LVH in 12%, Low voltage complex are seen in 24%. cardiomegaly seen in 20%.Conclusions: Study shows that, there was significant incidence of subclinical cardiac abnormalities observed in chronic liver disease patients which increase with duration of illness. Early detection of subclinical cardiac changes is important to reduce morbidity and mortality in chronic liver disease patients.

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Section: Agesupporting

confidence: 93%

Section: Agesupporting

confidence: 85%

Study of cardiac involvement in liver cirrhosis patients

et al. 2021

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“…The most common presentation was decrease appetite (88.5%), abdominal distension (88.5%), hematemesis and malena in 54.2%. 11 Ascites was seen in 80.0% patients, pallor in 66.67% patients, splenomegaly in 54.44% patients, icterus and pedal edema in 44.44 % patients, hepatomegaly in 17.78% patients. In a study conducted by Sukhwani N et al, included 35 patients of cirrhosis of liver.…”

Section: Discussionmentioning

confidence: 97%

Cardiovascular dysfunction in patients of cirrhosis of liver

et al. 2019

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Background: Cirrhosis of liver refers to a progressive condition that disrupts the normal architecture of the liver. It is increasingly recognized that cirrhosis per se can cause cardiac dysfunction. The aim was to assess cardiovascular dysfunction electrocardiographically and echocardiographically in patients with cirrhosis of liver and to find the correlation between cardiovascular dysfunction and severity of liver cirrhosis as per child-PUGH score.Methods: Total 90 patients of cirrhosis of liver of both sexes were included in this cross-sectional study conducted from January 2018 to August 2019 in SGRDIMSR, Sri Amritsar. The severity of liver cirrhosis was assessed as per Child Pugh Score. QTc interval was calculated by Bazett’s formula. Systolic and Diastolic dysfunction was seen on 2D-echocardiography.Results: QTc interval increased linearly with the severity of liver cirrhosis. Mean values of QTc in Child Pugh Class A=425.00(±20.97), Class B=437.35(±42.60), Class C=479.71(±29.48) with p value of 0.04 which is significant. Diastolic dysfunction was also related with the severity of liver cirrhosis. In Child Pugh Class A= 2(33%) patients had grade 1 diastolic dysfunction, Class B=23(59%) patients had grade 1 diastolic dysfunction while in Child Pugh Class C=3(7%) had grade 1 diastolic dysfunction, 33(73%) patients had grade 2 diastolic dysfunction and 1(2%) patients had grade 3 diastolic dysfunction with p value of 0.04 which is significant. Systolic function was found normal in all the patients.Conclusions: Diastolic dysfunction and QTc interval prolongation are both related with the severity of liver cirrhosis and are major criteria of cirrhotic cardiomyopathy.

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Echocardiographic abnormalities in patients with chronic liver disease

Chelakkat

Jacob

Sebastian

et al. 2021

MGM Journal of Medical Sciences

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Background: Chronic liver disease is an important cause of mortality as well as morbidity all over the world. Cirrhosis causes clinical manifestations extending beyond the liver. In patients with chronic liver disease, the cause of mortality is usually related to the liver pathology, but extrahepatic manifestations of chronic liver damage contribute significantly to the morbidity. With regards to the cardiovascular system, the manifestations are due to circulatory disturbances and cardiac dysfunction. Among all etiologies, cirrhotic cardiomyopathy is the cardiac dysfunction secondary to chronic liver disease. Objective: To study the echocardiographic abnormalities in patients with chronic liver disease. Materials and Methods: This was a cross-sectional study that was conducted on 80 patients in a tertiary care center. All etiologies for chronic liver disease were included. The diagnosis was confirmed by clinical features, laboratory and imaging criteria, and endoscopic evidence, and the duration of the abnormalities was to be persistent for more than six months. Echocardiography was done within one week of conducting the investigations. Echocardiography was done by the same cardiologist, who was a part of the study group, for all the patients. Results: The study cohort included 69 males and 11 females. The age ranged from 36 years to 76 years. The most common abnormality noted was left ventricular hypertrophy 48 (60%). Diastolic dysfunction was observed in 33 (41.5%). The other abnormalities noted include: left ventricular dilatation 5 (6.25%), dilated left atrium 13 (16.25%), increase in pulmonary artery pressure 15 (18.75%), and right ventricular dysfunction 10 (12.5%). Conclusion: Cirrhotic cardiomyopathy is a common but silent entity. A high index of suspicion is to be kept for this entity while managing patients with cirrhosis. The existence of this entity, if known, will be helpful in the management of patients during procedures or diseases that place stress on the heart. The use of newer modalities of imaging such as tissue Doppler imaging and two-dimensional speckle tracking echocardiography is more sensitive than conventional echocardiography for identifying cardiac dysfunction.

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Cardiac changes in patients with chronic liver disease: A prospective descriptive study

Cited by 3 publications

References 0 publications

Study of cardiac involvement in liver cirrhosis patients

Study of cardiac involvement in liver cirrhosis patients

Cardiovascular dysfunction in patients of cirrhosis of liver

Echocardiographic abnormalities in patients with chronic liver disease

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