Cardiac Conduction Defects and Cardiovascular Risk Factors -a Hospital Based Study.

Abstract

Background:The interest in cardiac conduction system has focused primarily on its role as a predictor of mortality and coexistent cardiovascular diseases particularly hospitalised patients. Objectives: The study was undertaken to study the association of cardiac conduction defects with underlying cardiovascular diseases and various risk factors. Methodology: The study was conducted from 1st March 2012 to 31st august 2013 and included cases >20yrs of age presenting to OPD or admitted in SMHS hospital and showing some form of cardiac conduction defect on a standard 12 lead ECG. A total of 1710 cases were studied. A thorough medical history and meticulous physical examination was done and relevant investigations ordered to find out the presence of underlying cardiovascular diseases and risk factors Results: Of the 1710 cases, 990(57.9%) were males and 720(42.1%) were females. Most of cases were seen in the age group of 70-79yrs (25.7%). Risk factors including Hypertension was found in 1095(64%) cases, Coronary Artery Disease(CAD) in 445(26%), dyslipidemia in 429(25%), diabetes in 410(23.9%) and gout in 51(2.9%) cases. 1270(74%) cases were smokers, 632(36.9%) were having sedentary life style and 496(29%) cases were obese/overweight. Conclusion: Hypertension, smoking, CAD, obesity and sedentary life style are the major risk factors.

Study to establish genetic association of cardiac conduction defect in Indian patients undergoing pacemaker implantation

“…LBBB was the commonest conduction defect in both the sexes in the research done by Ashraf et al with 27.7% in males and 31.5% in females. 9 The results of our study are in concordance to the study by Jain et al In both the studies, complete heart block was the most common CCD in both the sexes. In a study published by Jain et al out of 312 patients, 82.05% patients were suffering from acquired AV block, in which 68.26% had CHB and 13.78% had symptomatic, high-grade AV block.…”

“…In this study, the mean age of the cases is 58.66±13.42 years. This is in concordance with an Indian study conducted by Ashraf et al 9 The mean age among males was 62±16 years and females were 62±15 years. The most commonly affected age group was 51-60 years comprising 27.10% of cases.…”

“…This finding was in concordance with the study by Ashraf et al which also showed that majority of the patients were hypertensive. 9 Refsgaurd et al published results regarding SCN1B. A total of 28 sequence variants were identified using variant analysis, seven in SCN1B, three in SCN2B, two in SCN3B, two in SCN4B, four in FHL1 and ten in LMNA.…”