Cardiac contraction-induced GLUT4 translocation requires dual signaling input

Luiken, Joost J. F. P.; Glatz, Jan F. C.; Neumann, Dietbert

doi:10.1016/j.tem.2015.06.002

Cited by 30 publications

(31 citation statements)

References 64 publications

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“…GLUT4 capacity (amount at the plasma membrane) is critically and rapidly regulated by insulin with additional impact made by muscle contraction [21,22]. Thus the presence and type of glucose transporter is critical.…”

Section: Eric Arthur Newsholme's Studies: the Basis Of Regulation In mentioning

confidence: 99%

Regulatory principles in metabolism–then and now

Curi

Newsholme

Marzuca‐Nassr

et al. 2016

Biochemical Journal

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The importance of metabolic pathways for life and the nature of participating reactions have challenged physiologists and biochemists for over a hundred years. Eric Arthur Newsholme contributed many original hypotheses and concepts to the field of metabolic regulation, demonstrating that metabolic pathways have a fundamental thermodynamic structure and that near identical regulatory mechanisms exist in multiple species across the animal kingdom. His work at Oxford University from the 1970s to 1990s was groundbreaking and led to better understanding of development and demise across the lifespan as well as the basis of metabolic disruption responsible for the development of obesity, diabetes and many other conditions. In the present review we describe some of the original work of Eric Newsholme, its relevance to metabolic homoeostasis and disease and application to present state-of-the-art studies, which generate substantial amounts of data that are extremely difficult to interpret without a fundamental understanding of regulatory principles. Eric's work is a classical example of how one can unravel very complex problems by considering regulation from a cell, tissue and whole body perspective, thus bringing together metabolic biochemistry, physiology and pathophysiology, opening new avenues that now drive discovery decades thereafter.

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Section: Eric Arthur Newsholme's Studies: the Basis Of Regulation In mentioning

confidence: 99%

Regulatory principles in metabolism–then and now

Curi

Newsholme

Marzuca‐Nassr

et al. 2016

Biochemical Journal

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“…In cardiac tissue the expression of GLUT4 is four times higher than that of GLUT1 [29]. Cardiac tissue primarily utilizes GLUT4 for its glucose uptake, but in diabetic patients there is a decrease in expression of GLUT4 and therefore a decrease in the uptake and utilization of glucose.…”

Section: Cellular Uptake and Utilization Of Molecular Fuelsmentioning

confidence: 99%

Diabetes-Related Cardiac Dysfunction

2017

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The proposal that diabetes plays a role in the development of heart failure is supported by the increased risk associated with this disease, even after correcting for all other known risk factors. However, the precise mechanisms contributing to the condition referred to as diabetic cardiomyopathy have remained elusive, as does defining the disease itself. Decades of study have defined numerous potential factors that each contribute to disease susceptibility, progression, and severity. Many recent detailed reviews have been published on mechanisms involving insulin resistance, dysregulation of microRNAs, and increased reactive oxygen species, as well as causes including both modifiable and non-modifiable risk factors. As such, the focus of the current review is to highlight aspects of each of these topics and to provide specific examples of recent advances in each area.

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“…A reduced expression of the insulin-regulated glucose transporter type-4 (GLUT4) isoform, which in itself plays an essential role in blood glucose regulation by transporting and mediating glucose uptake, 36 is purported to be a causative factor leading to insulin resistance and subsequent diabetic complications. 37 As the effect of physical activity on glycemic control and body composition is well documented, 34,38 exercise training could be used as a first line of treatment for type 2 diabetes, and numerous studies have also showed the efficacy of HIIT [39][40][41] and MICT 42,43 with regards to the effective management of the condition.…”

Section: Insulin Sensitivitymentioning

confidence: 99%

High Intensity Interval Training Vs Moderate Intensity Continuous Training in the Management of Metabolic Type Disease

Pearson

Macaluso

Hussain

2015

MOJAP

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Previously, the use of moderate-intensity continuous training (MICT) has generally been considered the most beneficial exercise treatment modality for the prevention/management of metabolic type disease. More recently, however, high-intensity interval training (HIIT) has emerged into the clinical setting as a potential alternative to traditional MICT in the management of such diseases, but the comparative effects are not well understood. Use of HIIT has the potential to induce favorable physiological remodeling that is similar or even superior to MICT, despite a considerably lower exercise volume and time commitment. Many studies have therefore examined the efficacy of HIIT relative to MICT with respect to reducing the development and progression of numerous metabolic conditions including obesity, type 2 diabetes, and the metabolic syndrome. Despite this, however, the efficacy of HIIT relative to MICT in reversing the specific symptoms and adverse effects of those at risk of, or afflicted with metabolic disease is not well understood. Moreover, HIIT is often perceived as very stressful and demanding, which could potentially render it unsafe and/ or unappealing for clinical populations whom are already at a higher risk of experiencing adverse events. Furthermore, the optimal prescriptive variables (volume, intensity, duration, rest) of a HIIT protocol that elicit the greatest benefits for each of the aforementioned clinical cohorts have not been established. This review article aims to explore the use of HIIT with respect to the above. Firstly, the efficacy of HIIT is examined relative to MICT in the management of metabolic diseases, with particular relevance to physiological adaptations, health outcomes, and potential mechanisms. Secondly, the potential safety issues relating to the suitability and tolerability of HIIT for clinical populations, as well as the optimal HIIT prescriptive variables for such clinical populations are discussed. authors utilized a HIIT protocol which has previously been shown to reduce body fat in overweight individuals, 20 one may speculate that the protocol was insufficient to promote significant improvements in body composition for their overweight subjects. In support of this, the authors also reported that peak BP (systolic BP<250mmHg) and heart rate (<90% MHR) were within normal limits for exercise, and the protocol was well tolerated by participants with no adverse events, which may question the specific exercise prescriptive variables adopted. Obesity is also characterized in many cases by a reduction in insulin sensitivity. 25 Here this has been associated with an increase in levels of TNF-α, this increase in TNF-α is thought to interfere with insulin related glucose signaling in the muscle viathe IRS-1/P13K pathways (25). Interestingly chronic exercise has been shown to significantly (P<0.01) lower the circulating levels of TNF-α. Keywords26 Hence, while the recent interest in HIIT has led to the notion that it may be more effective than MICT as a means of reducing bo...

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Cardiac contraction-induced GLUT4 translocation requires dual signaling input

Cited by 30 publications

References 64 publications

Regulatory principles in metabolism–then and now

Regulatory principles in metabolism–then and now

Diabetes-Related Cardiac Dysfunction

High Intensity Interval Training Vs Moderate Intensity Continuous Training in the Management of Metabolic Type Disease

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