Cardiac Dysfunction in Murine Autoimmune Myocarditis

Structural and electrical ventricular remodeling in rat acute myocarditis and subsequent heart failure

“…Although the role of I ss is unclear in the rat ventricle, the reduction of Kv1.5 is compatible with APD prolongation and may contribute to electrical remodeling. The change in L-Ca 2 + channel expression is controversial in various heart diseases [29,30]. In this study, although the expression of LCa 2 + mRNA corrected by troponin-T was unchanged, the expression of SERCA2a mRNA was depressed during the acute phase.…”

Antiarrhythmic effect of atorvastatin on autoimmune myocarditis is mediated by improving myocardial repolarization

“…TNF-α has been shown to induce the reduction of voltage-gated potassium channel and related molecules (Kv4.2 and KChIP-2 mRNA) in vitro (Kawada et al, 2006). Other potential mechanisms may include the inhibition of T cell responses and the prevention of deleterious effects of T lymphocytes on I to by Fas/FasL pathway (Less et al, 1999). Furthermore, atorvastatin may affect basal electrical activity by regulating potassium channel expression.…”

“…The down-regulation of potassium ion channels was associated with a prolonged action potential duration (APD) in both EAM mouse hearts and human end-stage failing hearts (Beuckelmann et al, 1993;Less et al, 1999). In the EAM mouse model, the cardiac transient outward current was significantly decreased due to the deleterious effects of T lymphocytes by the activation of Fas/FasL pathway (Less et al, 1999).…”

Electrical Remodeling of the Ventricular Myocardium in Myocarditis

“…Less et al reported the arrhythmogenic change in diseased myocytes and its the cellular electrophysiological basis, ie, APD prolongation associated with early after depolarization, in the myosin-induced EAM model in BALB/c mice. 25 They documented that the Ito current was depressed whereas the Ica L current was unchanged. Although their experimental model was different from ours, the electrophysiological findings in the present study were compatible with their findings.…”