1987
DOI: 10.1111/j.1365-2125.1987.tb03265.x
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Cardiac effects of beta‐adrenoceptor blockade with intrinsic sympathomimetic activity during submaximal exercise.

Abstract: 1. beta‐adrenoceptor blocking agents with intrinsic sympathomimetic activity (ISA) are characterized by lesser depression of cardiac performance during low levels of sympathetic stimulation than beta‐ adrenoceptor blocking agents lacking ISA. Studies of the effects of ISA on cardiac output and on the determinants of myocardial oxygen demand during submaximal exercise are described and distinct differences between beta‐adrenoceptor antagonists with and without ISA emerge. 2. At doses which produce similar effec… Show more

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Cited by 9 publications
(4 citation statements)
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“…Our analyses also suggested that exercising patients taking β‐blockade exhibited significantly lower (better) V E /VCO 2 slopes. Our work also showed that there were no differences between classifications of β‐blockers on the magnitude of exercise training adaptations, despite previous reports that β‐adrenoreceptor–blocking agents with intrinsic sympathomimetic activity (ISA) have lesser effects on exercise capacity 23 . The physiological rationale is that β‐blockers with ISA have smaller reductions in heart rate compared with β‐blockers without ISA 8 .…”
Section: Discussioncontrasting
confidence: 61%
See 1 more Smart Citation
“…Our analyses also suggested that exercising patients taking β‐blockade exhibited significantly lower (better) V E /VCO 2 slopes. Our work also showed that there were no differences between classifications of β‐blockers on the magnitude of exercise training adaptations, despite previous reports that β‐adrenoreceptor–blocking agents with intrinsic sympathomimetic activity (ISA) have lesser effects on exercise capacity 23 . The physiological rationale is that β‐blockers with ISA have smaller reductions in heart rate compared with β‐blockers without ISA 8 .…”
Section: Discussioncontrasting
confidence: 61%
“…Heterogeneity: Chi² = 0.14, df = 1 (P = 0.71); I² = 0% Test for overall effect: Z = 0.12 (P = 0.90) exercise capacity. 23 The physiological rationale is that b-blockers with ISA have smaller reductions in heart rate compared with b-blockers without ISA. 8 Other effects of ISA are reduced skeletal and cardiac cardiotoxicity and inhibited myocardial apoptosis.…”
Section: Total (95% Ci)mentioning
confidence: 99%
“…Further comparative studies of the effect of this antihypertensive combination should involve monotherapy phases with both enalapril and nadolol, preferably in a crossover design (with adequate washout between the different phases. There was no evidence of any reduction in exercise capacity of patients on combination therapy, as has been previously reported for other beta antagonists [20][21][22].…”
Section: Discussionsupporting
confidence: 54%
“…for physically active patients with hypertension (van Baak, 1988). It has been suggested that @-blocking agents with intrinsic sympathetic activity (ISA) would have a lower deteriorating effect on physical performance (Ades, 1987), but this has been questioned in several studies (Duncan et al, 1990;Martin et al, 1989). In patients with coronary heart disease the disease itself is often the limiting factor for the highest performance levels, and it may even be advantageous to maintain the physical activity on the most economical level for cardiac metabolism.…”
Section: Introductionmentioning
confidence: 99%