Cardiac electrical remodeling and neurodegenerative diseases association

Joviano‐Santos, Julliane V.; Santos‐Miranda, Artur; Roman‐Campos, Danilo

doi:10.1016/j.lfs.2020.118976

Cited by 2 publications

(2 citation statements)

References 140 publications

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“…Furthermore, we have highlighted the data reporting the presence of α-synuclein accumulation in cardiac tissue and patients’ alterations in neurocardiac regulation. Based on the cardiovascular-related features of PD, we propose that there may be substantial changes in the electrophysiological activity and remodeling of the myocardium, in the hearts of PD patients [ 22 , 78 ]. However, a complete electrophysiological understanding of the heart, and the cardiac autonomic nervous system, remain to be determined due to a lack of translational studies.…”

Section: Discussionmentioning

confidence: 99%

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Clinical and Non-Clinical Cardiovascular Disease Associated Pathologies in Parkinson’s Disease

Lee

Edling

Ahmad

et al. 2023

IJMS

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Despite considerable breakthroughs in Parkinson’s disease (PD) research, understanding of non-motor symptoms (NMS) in PD remains limited. The lack of basic level models that can properly recapitulate PD NMS either in vivo or in vitro complicates matters. Even so, recent research advances have identified cardiovascular NMS as being underestimated in PD. Considering that a cardiovascular phenotype reflects sympathetic autonomic dysregulation, cardiovascular symptoms of PD can play a pivotal role in understanding the pathogenesis of PD. In this study, we have reviewed clinical and non-clinical published papers with four key parameters: cardiovascular disease risks, electrocardiograms (ECG), neurocardiac lesions in PD, and fundamental electrophysiological studies that can be linked to the heart. We have highlighted the points and limitations that the reviewed articles have in common. ECG and pathological reports suggested that PD patients may undergo alterations in neurocardiac regulation. The pathological evidence also suggested that the hearts of PD patients were involved in alpha-synucleinopathy. Finally, there is to date little research available that addresses the electrophysiology of in vitro Parkinson’s disease models. For future reference, research that can integrate cardiac electrophysiology and pathological alterations is required.

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Section: Discussionmentioning

confidence: 99%

“…The result may be translated as a consequence of PD. However, so far, no research has been published demonstrating cardiac electrophysiology alteration in disease models with established PD risk factor genes [ 78 ].…”

Section: Electrophysiology In Parkinson’s Disease Modelsmentioning

confidence: 99%