Cardiac Event Risk in Japanese Subjects Estimated Using Gated Myocardial Perfusion Imaging, in Conjunction With Diabetes Mellitus and Chronic Kidney Disease

Nakajima, Kénichi; Matsuo, Shinro; Okuyama, Chio; Hatta, Tsuguru; Tsukamoto, Kazumasa; Nishimura, Shigeyuki; Yamashina, Akira; Kusuoka, Hideo

doi:10.1253/circj.cj-11-0857

Cited by 48 publications

(44 citation statements)

References 34 publications

(27 reference statements)

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“…However, the main cause of cardiac events in Japanese patients with and without CKD was reported as severe HF. 19 The MPI defect score was relatively lower than those previously reported. [10][11][12][13] Since we excluded patients with CKD who had CAD, such a small defect might impact cardiac events in patients without such a diagnosis.…”

Section: Limitationscontrasting

confidence: 55%

“…We previously showed that cardiac event risk could be estimated from MPI defect scores and LVEF in conjunction with CKD and diabetes in patients with confirmed or suspected CAD, and the increase in cardiac events was almost 2-fold higher among patients with SSS C9. 19 In this study, about half of patients had cardiac symptoms or ECG abnormalities. According to the appropriate use criteria for diagnostic catheterization, 20 these patients were considered to have intermediate or high probability of CAD.…”

Section: Discussionmentioning

confidence: 71%

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Prognostic study of cardiac events in Japanese patients with chronic kidney disease using ECG-gated myocardial Perfusion imaging: Final 3-year report of the J-ACCESS 3 study

Nakamura

Kawano

Nakajima

et al. 2019

Journal of Nuclear Cardiology

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Section: Limitationscontrasting

confidence: 55%

Section: Discussionmentioning

confidence: 71%

Prognostic study of cardiac events in Japanese patients with chronic kidney disease using ECG-gated myocardial Perfusion imaging: Final 3-year report of the J-ACCESS 3 study

Nakamura

Kawano

Nakajima

et al. 2019

Journal of Nuclear Cardiology

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“…Third, besides CKD, new biomarkers that can predict the CHD risk are emerging [55][56][57] . However, our study could not access their importance as have other existing prediction tools for Japanese subjects.…”

Section: Discussionmentioning

confidence: 99%

Predicting Coronary Heart Disease Using Risk Factor Categories for a Japanese Urban Population, and Comparison with the Framingham Risk Score: The Suita Study

Nishimura

Okamura

Watanabe

et al. 2014

JAT

182

103

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Aim:The Framingham risk score (FRS) is one of the standard tools used to predict the incidence of coronary heart disease (CHD). No previous study has investigated its efficacy for a Japanese population cohort. The purpose of this study was to develop new coronary prediction algorithms for the Japanese population in the manner of the FRS, and to compare them with the original FRS. Methods: Our coronary prediction algorithms for Japanese were based on a large population-based cohort study (Suita study). The study population comprised 5,521 healthy Japanese. They were followed-up for 11.8 years on average, and 213 cases of CHD were observed. Multiple Cox proportional hazard model by stepwise selection was used to construct the prediction model.

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“…Risk stratification of cardiac events by nuclear cardiology has been demonstrated in some large-scale prognostic studies including the multicenter prospective Japanese Assessment of Cardiac Events and Survival Study in patients with ischemic heart disease (J-ACCESS), 5) in asymptomatic patients with type 2 diabetes (J-ACCESS 2), 6) in patients with chronic kidney disease (J-ACCESS 3), 7) and in another single-center large-scale prospective study. 8) Nakajima, et al 9) published a Heart Risk Table, which is the first cardiac event risk score predicting the risk of major cardiac events (MCEs) in Japanese patients with CAD within 3 years, prepared on the basis of predictors obtained from the J-ACCESS database (n = 2,395). MCEs predicted with the Heart Risk Table, however, include severe heart failure unlike MCEs defined in non-Japanese studies.…”

Section: Tl and Stress 99mmentioning

confidence: 99%

Prognostic Value of Major Cardiac Event Risk Score Estimated With Gated Myocardial Perfusion Imaging in Japanese Patients With Coronary Artery Disease

et al. 2016

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SummaryWe published a cardiac event risk score (CERS) predicting the risk of major cardiac events (MCEs) within 3 years. The purpose of this study was to verify the prognostic value of the CERS before and after treatment in Japanese patients with coronary artery disease.We retrospectively investigated 612 patients who underwent rest 201Tl and stress 99mTc-tetrofosmin myocardial perfusion single photon emission computed tomography (SPECT) between October 2004 and March 2013 and who had a significant stenosis with ≥ 75% narrowing of the arterial diameter detected by coronary angiography performed after confirmation of ≥ 5% ischemia with the SPECT. The patients underwent treatment including revascularization and medication, and thereafter, were re-evaluated with SPECT during a chronic phase and followed-up to confirm prognosis for ≥ 1 year. The endpoint was the onset of MCEs during the follow-up.During the follow-up (36.7 ± 14.5 months), 50 patients (8.7%) experienced MCEs comprising cardiac death (n = 16), non-fatal myocardial infarction (n = 4), and unstable angina pectoris (n = 30). The multivariate Cox proportional hazards regression model analysis for the actual occurrence of MCEs showed the summed difference score % and MCE risks estimated with the CERS after treatment to be significant independent variables. Ischemic reduction after treatment contributed significantly to a decrease in the MCE risks. The MCE risks estimated with the CERS after treatment were generally consistent with the incidence of the MCEs actually observed.The CERS after treatment is a valuable formula for predicting prognosis in Japanese patients with coronary artery disease. (Int Heart J 2016; 57: 408-416)

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Cardiac Event Risk in Japanese Subjects Estimated Using Gated Myocardial Perfusion Imaging, in Conjunction With Diabetes Mellitus and Chronic Kidney Disease

Cited by 48 publications

References 34 publications

Prognostic study of cardiac events in Japanese patients with chronic kidney disease using ECG-gated myocardial Perfusion imaging: Final 3-year report of the J-ACCESS 3 study

Prognostic study of cardiac events in Japanese patients with chronic kidney disease using ECG-gated myocardial Perfusion imaging: Final 3-year report of the J-ACCESS 3 study

Predicting Coronary Heart Disease Using Risk Factor Categories for a Japanese Urban Population, and Comparison with the Framingham Risk Score: The Suita Study

Prognostic Value of Major Cardiac Event Risk Score Estimated With Gated Myocardial Perfusion Imaging in Japanese Patients With Coronary Artery Disease

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