Cardiac fibroblast heat shock protein 47 aggravates cardiac fibrosis post myocardial ischemia–reperfusion injury by encouraging ubiquitin specific peptidase 10 dependent Smad4 deubiquitination

Xie, Saiyang; Xing, Yun; Shi, Wenke; Zhang, Min; Chen, Mengya; Fang, Wenxi; Liu, Shiqiang; Zhang, Tong; Zeng, Xiaofeng; Chen, Si; Wang, Shasha; Deng, Wei; Tang, Qi‐Zhu

doi:10.1016/j.apsb.2022.07.022

Cited by 24 publications

(7 citation statements)

References 58 publications

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“…For measuring mice's cardiac function, mice were given 1.5% isoflurane anaesthesia and then put on a heating pad. Transthoracic echocardiography was analyzed with a 10-MHz linear array ultrasound transducer equipped with a 30-MHz probe (Vevo 3100 system Visual Sonics) as described in our previous study 16 , 17 . The echocardiographic parameters, including left ventricular ejection fraction (LVEF), left ventricular fractional shortening (LVFS) and left ventricular end-systolic dimension (LVESd) were calculated and averaged from at least five consecutive cardiac cycles.…”

Section: Methodsmentioning

confidence: 99%

Idebenone alleviates doxorubicin-induced cardiotoxicity by stabilizing FSP1 to inhibit ferroptosis

Qiu,

Huang,

Liu

et al. 2024

Acta Pharmaceutica Sinica B

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Section: Methodsmentioning

confidence: 99%

Idebenone alleviates doxorubicin-induced cardiotoxicity by stabilizing FSP1 to inhibit ferroptosis

Qiu,

Huang,

Liu

et al. 2024

Acta Pharmaceutica Sinica B

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“…It is demonstrated that, in fibroblasts, HSP47 aggravated chronic fibrosis after myocardial ischaemia-reperfusion by recruiting USP10, which removed the ubiquitin chains of Smad4, and stabilized Smad4 protein (Ref. 90 ).…”

Section: Role Of Deubiquitinases In Cardiac Diseasementioning

confidence: 99%

The role of deubiquitinases in cardiac disease

Zhan,

Yang,

et al. 2024

Expert Rev. Mol. Med.

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Deubiquitinases are a group of proteins that identify and digest monoubiquitin chains or polyubiquitin chains attached to substrate proteins, preventing the substrate protein from being degraded by the ubiquitin-proteasome system. Deubiquitinases regulate cellular autophagy, metabolism and oxidative stress by acting on different substrate proteins. Recent studies have revealed that deubiquitinases act as a critical regulator in various cardiac diseases, and control the onset and progression of cardiac disease through a board range of mechanism. This review summarizes the function of different deubiquitinases in cardiac disease, including cardiac hypertrophy, myocardial infarction and diabetes mellitus-related cardiac disease. Besides, this review briefly recapitulates the role of deubiquitinases modulators in cardiac disease, providing the potential therapeutic targets in the future.

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“…Cardiomyocyte cross-sectional area and collagen deposition were determined by Masson's trichrome (collagen, blue; cytoplasm, red/pink) or Wheat Germ Agglutinin (WGA) staining according to our previously reported [29].…”

Section: Histological Analysismentioning

confidence: 99%

Isthmin-1 Improves Aging-Related Cardiac Dysfunction in Mice through Enhancing Glycolysis and SIRT1 Deacetylase Activity

Hu,

Zhang,

Gao

et al. 2024

Aging and disease

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Aging-related cardiac dysfunction poses a major risk factor of mortality for elderly populations, however, efficient treatment for aging-related cardiac dysfunction is far from being known. Isthmin-1 (ISM1) is a novel adipokine that promotes glucose uptake and acts indispensable roles in restraining inflammatory and fibrosis. The present study aims to investigate the potential role and molecular mechanism of ISM1 in aging-related cardiac dysfunction. Aged and matched young mice were overexpressed or silenced with ISM1 to investigate the role of ISM1 in aging-related cardiac dysfunction. Moreover, H9C2 cells were stimulated with D-galactose (D-gal) to examine the role of ISM1 in vitro. Herein, we found that cardiac-specific overexpression of ISM1 significantly mitigated insulin resistance by promoting glucose uptake in aging mice. ISM1 overexpression alleviated while ISM1 silencing deteriorated cellular senescence, cardiac inflammation, and dysfunction in natural and accelerated cardiac aging. Mechanistically, ISM1 promoted glycolysis and activated Sirtuin-1 (SIRT1) through increasing glucose uptake. ISM1 increased glucose uptake via translocating GLUT4 to the surface, thereby enhancing glycolytic flux and hexosamine biosynthetic pathway (HBP) flux, ultimately leading to increased SIRT1 activity through O-GlcNAc modification. ISM1 may serve as a novel potential therapeutic target for preventing aging-related cardiac disease in elderly populations. ISM1 prevents aging-related cardiac dysfunction by promoting glycolysis and enhancing SIRT1 deacetylase activity, making it a promising therapeutic target for aging-related cardiac disease.

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Cardiac fibroblast heat shock protein 47 aggravates cardiac fibrosis post myocardial ischemia–reperfusion injury by encouraging ubiquitin specific peptidase 10 dependent Smad4 deubiquitination

Cited by 24 publications

References 58 publications

Idebenone alleviates doxorubicin-induced cardiotoxicity by stabilizing FSP1 to inhibit ferroptosis

Idebenone alleviates doxorubicin-induced cardiotoxicity by stabilizing FSP1 to inhibit ferroptosis

The role of deubiquitinases in cardiac disease

Isthmin-1 Improves Aging-Related Cardiac Dysfunction in Mice through Enhancing Glycolysis and SIRT1 Deacetylase Activity

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