Cardiac fibrosis in three dimensions – mechanistic insights into arrhythmic risk due to hypertrophy

Cell diversity and signalling in the cardiovascular system

“…The notion that structural and electrophysiological remodelling are intricately linked is also nicely demonstrated in a recent paper in The Journal elucidating the role of cardiac fibrotic remodelling in repolarization heterogeneity and ventricular arrhythmia risk in aged spontaneously hypertensive rats (Khwaounjoo et al., 2022). As suggested in the accompanying translational perspective, arrhythmia is likely to reflect the balance between macro‐structure and functional control, whereby neural remodelling might play a key regulatory role of arrhythmogenesis in the setting of scars (Shivkumar et al., 2023). In a computational study included in this special issue, Gibbs et al.…”