Cardiac Function After Radiation Therapy for Breast Cancer

Abstract

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Early Cardiac Effects of Contemporary Radiation Therapy in Patients With Breast Cancer

“…We attribute the results of our study primarily to the successes in minimizing cardiac exposure in thoracic RT with cardiac contouring and with the increased use of DIBH techniques and some patients receiving proton therapy. Of note, the MHD in our longitudinal study was significantly lower than the previously reported series (7,9,10,26,(32)(33)(34)(35).…”

“…To date, studies assessing acute radiation cardiotoxicity have had small patient numbers without the use of contemporary RT techniques and anticancer regimens (7,26). Our study design and patient enrollment more accurately reflect current chemotherapy and RT practices for breast cancer more so than previously reported in the literature (7)(8)(9)(10)26,32,33). The XXXX cohort had a high retention rate with minimal missing data (< 5%).…”

Hyperoside Induces Breast Cancer Cells Apoptosis via ROS-Mediated NF-κB Signaling Pathway

“…Breast cancer is the leading cause for female death, followed by colorectal cancer and lung cancer [2]. Traditional therapies for breast cancer involve surgery, radiotherapy and chemotherapy [3,4], while there are many new methods like endocrine therapy, biological target therapy and traditional Chinese medicine therapy [5,6]. Chinese medicine now has tremendous importance in chemotherapy as it has lesser side effects and toxicity [7], thus a great deal of studies has been devoted to identify novel drugs with potential for breast cancer treatment in recent years.…”

A Prospective Study of Early Radiation Associated Cardiac Toxicity Following Neoadjuvant Chemoradiation for Distal Esophageal Cancer

“…Notably we were able to detect this damage even earlier, as soon as 3 months following treatment with corresponding cardiac functional impairments. Other studies have demonstrated the impact of radiation dose on various segments of the heart including the left ventricle and the left mainstem coronary artery ( 25 , 26 ). Although we were unable to detect a dose—volume relationship with the observed heart damage in the basal septum, we did find that in 2 of 3 patients with heart damage over 60% of the damaged segments received a dose of 30 Gy.…”