Cardiac function and aminoterminal pro‐brain natriuretic peptide levels in liver‐transplanted cirrhotic patients

Bernal, Vanesa; Pascual, Isaac; Lanas, Ángel; Esquivias, Paula; Piazuelo, Elena; García-Gil, Francisco A.; Lacambra, Isaac; Simón, Miguel Ángel

doi:10.1111/j.1399-0012.2011.01438.x

Cited by 11 publications

(13 citation statements)

References 31 publications

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“…Henriksen et al (2003) reported that BNP levels were related to markers of cardiac dysfunction, such as QT interval, heart rate, and plasma volume. In contrast to previ-ous studies (Padillo et al, 2010;Bernal et al, 2012), there was no relationship between BNP concentration and QTc interval identified in our research. It has been reported that a level of BNP over 500 pg/mL is diagnostic for the congestive heart failure presented and diagnosed by a lower ejection fraction on echocardiographic examination (Buğdaycı and Sökmen, 2012).…”

Section: Discussioncontrasting

confidence: 99%

B-type natriuretic peptide and cirrhosis progression

Shi¹,

Jin²,

Lin³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. Brain natriuretic peptide (BNP) is used as a marker of cardiac dysfunction to predict heart failure mortality. The significance of the prognostic ability of BNP for liver cirrhosis remains unknown, although the levels of BNP seen in cirrhosis are high. We aimed to determine whether the BNP level is related to the stage of cirrhosis and could serve as a prognostic marker of cirrhosis (predict the 1-year all-cause mortality). We recruited 92 patients at different stages of cirrhosis and 81 controls matched by age and gender for this study. At admission, cardiac physical examination and BNP measurements were performed. Upon discharge, the 89 patients were followed up for 12 months. The median BNP levels of patients with cirrhosis were 167.0 pg/mL, which were significantly higher than those of the control group (167.0 vs 34.8 pg/mL, P = 0.001). Serum BNP levels were positively correlated with the Child score, the grade of esophageal varices, a history of spontaneous bacterial peritonitis, and the presence of ascites 5189 B-type natriuretic peptide and cirrhosis progression ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (2): 5188-5196 (2015) and collateral circulation. BNP levels above the median were associated with an increased occurrence of death within 12 months of discharge (log rank P = 0.025), as determined by univariate and multivariate Cox regression analyses. Esophageal varices, large/medium volume ascites, and BNP levels were related to the clinical outcome (P = 0.034, 0.030, and 0.025, respectively). Together, these results suggested that serum BNP levels are significantly correlated with the stage of cirrhosis, suggesting that BNP levels might serve as a significant predictor for 1-year all-cause mortality.

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Section: Discussioncontrasting

confidence: 99%

B-type natriuretic peptide and cirrhosis progression

Shi¹,

Jin²,

Lin³

et al. 2015

Genet. Mol. Res.

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“…According to literature, in our study we found a significant increase in cardiac mass, atrial volume and diastolic dysfunction in HCV‐related cirrhotic patients . The increase in left ventricular mass is due to volume overload secondary to expansion of blood volume and activation of neuro‐hormonal systems commonly observed in these patients .…”

Section: Discussionsupporting

confidence: 69%

Subclinical cardiovascular damage in patients with HCV cirrhosis before and after treatment with direct antiviral agents: a prospective study

Novo

Macaione

Giannitrapani

et al. 2018

Aliment Pharmacol Ther

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“…[18,20] On the other hand, Li et al also showed that the prolonged QTc interval duration became normal in 17 of 20 patients undergoing liver transplantation, [19] indicating the impact of liver cirrhosis on heart function. [21,22] Additionally, QTc interval was found weakly associated with MELD score. The proportion of QTc prolongation had an upward tendency with the increase of Child-Pugh grade.…”

Section: Discussionmentioning

confidence: 99%

Cardiac health in patients with hepatitis B virus-related cirrhosis

Yuan¹,

Xue³

et al. 2019

Medicine

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Not only alcoholic cirrhosis related to cardiac dysfunction, cirrhosis caused by nonalcoholic etiology including hepatitis B virus (HBV) infection also related to impaired cardiac health. The aims of present study were to perform a noninvasive evaluation of cardiac function and to evaluate exercise performance in HBV related cirrhotic patients without typical symptoms of cardiac disease. Seventy-nine HBV related cirrhotic patients and 103 matched subjects without a previous history of cardiac involvement were recruited. Clinical examination and cardiac health evaluation were performed. The incidence, risk factors of cardiac dysfunction and exercise tolerance were investigated. A correlation between QTc interval and model for end-stage liver disease score ( R = 0.239, P = .018) was detected, however, the connection between QTc prolongation and the severity of liver disease was uncertain. Patients with HBV related cirrhosis had a tendency toward left ventricular wall thickening ( P = .007). Forty-one patients (51.90%) were in accordance with the definition of cirrhotic cardiomyopathy, and a significant increase in the incidence of cardiac diastolic dysfunction (CDD) could be found with increasing Child-Pugh grade ( P = .004). HBV related cirrhotic patients with CDD had a higher level of pro-brain natriuretic peptide ( P = .025), international normalized ratio ( P = .010) Child-Pugh score ( P = .020), and a higher proportion of ascites ( P < .001). The higher Child-Pugh score (odds ratio = 1.662, P = .010) was an independent diagnostic predictor of CDD. The cardiac depression and exercise tolerance also got worse with increasing Child-Pugh score ( P < .001). Impaired cardiac health was common in HBV related cirrhotic patients. Cardiogenic factors must be carefully considered in the integral therapy of cirrhosis. Hepatology physicians should lay emphasis on exercise training in daily life.

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Cardiac function and aminoterminal pro‐brain natriuretic peptide levels in liver‐transplanted cirrhotic patients

Abstract: In cirrhotic patients, diastolic function and cardiac structure deteriorate after LT. Compared to controls, NT-proBNP levels tend to be higher before and after transplantation. The mechanisms and consequences of these results require further study.

Cited by 11 publications

References 31 publications

B-type natriuretic peptide and cirrhosis progression

B-type natriuretic peptide and cirrhosis progression

Subclinical cardiovascular damage in patients with HCV cirrhosis before and after treatment with direct antiviral agents: a prospective study

Cardiac health in patients with hepatitis B virus-related cirrhosis

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