Cardiac Function and Oxygen Balance in Septic Patients during Continuous Hemofiltration

Meloni, Carlo; Morosetti, Massimo; Turani, Franco; Palombo, G.; Meschini, L.; Zupancich, E.; Taccone-Gallucci, M; Giulio, Salvatore Di; Casciani, Carlo Umberto

doi:10.1159/000014327

Cited by 5 publications

(1 citation statement)

References 28 publications

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“…Meloni et al (25) have demonstrated that CHDF is useful in septic patients to correct fluid overload and ARF, without affecting hemodynamic stability and oxygen balance. These results raise a possibility that this technique will improve the prognosis of septic patients complicated with ARF.…”

Section: Discussionmentioning

confidence: 99%

Continuous Hemodiafiltration with Polymyxin‐B Immobilized Fiber Is Effective in Patients with Sepsis Syndrome and Acute Renal Failure

Suzuki

Nemoto

Nakamoto

et al. 2002

Therapeutic Apheresis

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The aim of this study was first, to evaluate the effects of continuous hemodiafiltration (CHDF) alone or combined with CHDF and polymyxin-B immobilized fiber (PMX) on survival rates of patients with sepsis and acute renal failure, and second, to evaluate the changes in plasma levels of inflammatory cytokines before and after treatment with CHDF and PMX and CHDF alone in these patients. Forty-eight patients with septic shock and acute renal failure were enrolled in this study. The survival rate of all patients at 28 days was 25% for those with CHDF and 75% for those with PMX and CHDF treatment. Combination treatment produced a significant reduction of plasma levels of endotoxin and interleukin-6 compared to the basal values and to the treatment with CHDF alone. From these data, it is suggested that the combined therapy with PMX and CHDF is effective in improvement of survival rate of patients with septic shock and acute renal failure.

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Section: Discussionmentioning

confidence: 99%

Continuous Hemodiafiltration with Polymyxin‐B Immobilized Fiber Is Effective in Patients with Sepsis Syndrome and Acute Renal Failure

Suzuki

Nemoto

Nakamoto

et al. 2002

Therapeutic Apheresis

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Selection of hemoperfusion therapy for patients with septic shock on the basis of the primary disease

Kanno

Nemoto

Nakamoto

et al. 2003

Journal of Artificial Organs

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The objective of this study was to analyze retrospectively the efficacy of polymyxin-B immobilized fiber (PMX-F) alone and in combination with continuous venovenous hemofiltration (CHF) on the prognosis of critically ill patients with sepsis using a retrospective chart review in a university hospital in Japan. A cohort of 246 patients meeting the criteria of sepsis, septic shock, or both, according to the American College of Chest Physicians/Society of Critical Care Medicine (ACCP/ACCM) Consensus Conference, were examined in this study. From these patients, 48 were selected who were found to have definitive causative bacteria and whose primary diseases were clearly identified. According to the charts, two major primary diseases were identified: one related to cardiovascular disease and the other to gastrointestinal disease. Other diseases were excluded from this study because of the small numbers of patients in categories such as malignant, hematological, genitourinary, and other diseases. Furthermore, patients who had levels of serum creatinine above 2.0 mg/dl were excluded. The prevalence of diabetes mellitus (up to 63%) was very high in both groups. There were no significant differences between the two groups in age or the Apache II scores at the start of hemoperfusion treatment; however, the gender ratio varied: 72% of the cardiovascular group were male, compared to 46% of the gastrointestinal group. The causative bacteria were markedly different between the two groups. For half of the gastrointestinal group the causative bacterium was Escherichia coli, while for half of the cardiovascular group the causative bacterium was Pseudomonas aeruginosa. The survival rate differed significantly between the two groups. The patients in the cardiovascular group survived longer than those in the gastrointestinal group. Moreover, for the patients with cardiovascular disease, there was no significant difference in the survival rate between treatment with PMX-F alone and with PMX-F and CHF in combination. In contrast, for the patients with gastrointestinal disease, there was a significant difference between treatment with PMX-F alone and with PMX-F and CHF in combination. When a patient with sepsis or septic shock is treated with hemoperfusion, the decision as to whether PMX-F should be given alone or in combination with CHF might be determined on the basis of the primary disease of the patient.

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Hemofiltration in sepsis and systemic inflammatory response syndrome: The role of dosing and timing

Bouman

Straaten

Schultz

et al. 2007

Journal of Critical Care

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Cardiac Function and Oxygen Balance in Septic Patients during Continuous Hemofiltration

Cited by 5 publications

References 28 publications

Continuous Hemodiafiltration with Polymyxin‐B Immobilized Fiber Is Effective in Patients with Sepsis Syndrome and Acute Renal Failure

Continuous Hemodiafiltration with Polymyxin‐B Immobilized Fiber Is Effective in Patients with Sepsis Syndrome and Acute Renal Failure

Selection of hemoperfusion therapy for patients with septic shock on the basis of the primary disease

Hemofiltration in sepsis and systemic inflammatory response syndrome: The role of dosing and timing

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