Cardiac function during resuscitation from hemorrhagic shock with polymerized bovine hemoglobin-based oxygen therapeutic

Abstract

Hemorrhage impairs myocardial contractile function and decreases oxygen delivery. This study investigates how polymerized bovine hemoglobin (PolyHb) solutions affect cardiac function after resuscitation from hemorrhagic shock (HS). Hamsters were hemorrhaged and resuscitated with PolyHb at 8.5g/dL and 11.5 g/dL. Left ventricle (LV) function was assessed during shock and resuscitation using a miniaturize conductance catheter. PolyHb resuscitation had no beneficial effects in cardiac function; it increased cardiac afterload and systemic vascular resistance (SVR) of 46 and 116% for 8.5 and 11.5 g/dL, respectively. Study findings indicate that preclinical evaluation of cardiac function is essential to develop safe and efficacious alternatives to blood transfusion.

Case of resuscitation from cardiac failure by intrauterine transfusion after single fetal death in monochorionic twin pregnancy

“…Although these cases have suggested the hypovolemic state of co‐twins, there is no report on the evidence of fetal circulatory insufficiency. Cardiac failure is reportedly induced by hypovolemic shock caused by massive bleeding in animal experiments . In our case, low FS and high MPI were observed despite the absence of congenital heart disease at the detection of single FD, which improved rapidly after IUT.…”

“…Cardiac failure is reportedly induced by hypovolemic shock caused by massive bleeding in animal experiments. 13,14 In our case, low FS and high MPI were observed despite the absence of congenital heart disease at the detection of single FD, which improved rapidly after IUT. The decreased FS indicated the decreased preload and decreased cardiac function.…”

“…Immediate IUT may improve the cardiac function and prevent poor perinatal outcome. Cardiac failure was induced by massive hemorrhage recovery with blood transfusion or dextran infusion in animal experiments . Ninety‐three percent of the co‐twins of a single FD in an MC twin pregnancy with superficial anastomoses had poor vital or neurological outcomes without IUT .…”

Global longitudinal strain changes during hemorrhagic shock: An experimental study

“…Hemorrhagic shock (HS) reduces tissue perfusion and oxygen delivery, leading to cellular dysfunction and multiple organ failure. [ 5 ] The first line of HS treatment is to restore circulatory stability with rapid fluid administration and many studies suggest that vasopressors may be beneficial to treat. [ 6 7 ] In the presence of life-threatening hypotension, administration of vasopressors, particularly norepinephrine (NE), is recommended in addition to fluids to maintain target arterial pressure.…”

In vivoevaluation of electron mediators for the reduction of methemoglobin encapsulated in liposomes using electron energies produced by red blood cell glycolysis

“…Moreover, its use entails various complicated, time-consuming and expensive blood tests, creating persistent conditions of blood supply shortage. Alternative blood substitutes such as haemoglobinbased oxygen carriers (HBOCs) are believed to have the capacity to ease blood supply shortages and alleviate many blood transfusion-related issues [1][2][3][4][5][6]. Actually, HBOCs can be produced in a way that eliminates viral infections such as HIV and hepatitis.…”