Cardiac function following combination therapy with paclitaxel and doxorubicin: An analysis of 657 women with advanced breast cancer

Abstract

The reported cardiac effects are consistent with anthracycline-related cardiotoxicity. AT is associated with a cardiac risk similar to that of A monotherapy up to a cumulative A dose of 340-380 mg/m2.

Reversible cardiotoxicity in a 54-year-old woman treated with trastuzumab

“…Trastuzumab has been administered in combination with placlitaxel to treat women who have not previously received CT for metastatic breast cancer 8 . Asymptomatic arrhythmias occur in association with the use of paclitaxel, and more severe cardiac adverse effects are related to CT schedules containing anthracyclines 1,3,6,9 . The concomitant use of trastuzumab and paclitaxel has been also associated with increased risk of cardiotoxicity 8 .…”

I Diretriz Brasileira de Cardio-Oncologia da Sociedade Brasileira de Cardiologia

“…Isso acontece porque o paclitaxel interage com a doxorrubicina, diminuindo o clearance desse quimioterápico e de seu metabólito (doxorrubicinol), aumentado sua concentração plasmática e tecidual 189,190 . Estudos recentes sugerem que a associação do paclitaxel com doxorrubicina pode ser segura do ponto de vista cardiovascular se mantida a dose cumulativa de doxorrubicina no máximo até 340-380 mg/m 183,184,[191][192][193] . [194][195][196] .…”

“…O docetaxel, um taxano semissintético, é responsável por uma incidência de disfunção ventricular entre 2,3% e 8% 191,192 . Assim como o paclitaxel, sua associação com doxorrubicina é bem tolerada [197][198][199] .…”

Erratum to: Exercise Therapy in the Management of Solid Tumors

“…• In the mid-to-late 1980s, researchers initiated the first studies to explore whether exercise training may be an appropriate intervention to mitigate chemotherapy-and radiation-induced fatigue and loss of cardiorespiratory fitness among women with early-stage breast cancer [8][9][10][11][12][13]. Since this early seminal study, the number of publications has steadily increased over the past 20 years with studies becoming progressively more sophisticated in scope, design, and size to address the major questions in the field [14].…”