Cardiac Geometry in Children Receiving Chronic Peritoneal Dialysis

Bakkaloğlu, Sevcan A.; Borzych, Dagmara; Ha, Il Soo; Serdaroğlu, Erkin; Büscher, Rainer; Salas, Paulina; Patel, Hiren P.; Drożdż, Dorota; Vondrák, Karel; Watanabe, Andréia; Villagrá, Jorge; Yavaşcan, Önder; Valenzuela, Maria; Gipson, Deborah; Ng, Kar Hui; Warady, Bradley A.; Schaefer, Franz

doi:10.2215/cjn.05990710

Cited by 83 publications

(52 citation statements)

References 35 publications

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“…69,70 For immunofluorescence, 1310 6 cells were seeded per well on glass coverslips in six-well plates. For protein and RNA isolation, 2310 6 cells were seeded in 6-cm culture dishes.…”

Section: Primary Culture Of Neonatal Rat Ventricular Myocytes and Carmentioning

confidence: 99%

Klotho and Phosphate Are Modulators of Pathologic Uremic Cardiac Remodeling

Hu¹,

Shi²,

Cho³

et al. 2015

Journal of the American Society of Nephrology

235

300

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Cardiac dysfunction in CKD is characterized by aberrant cardiac remodeling with hypertrophy and fibrosis. CKD is a state of severe systemic Klotho deficiency, and restoration of Klotho attenuates vascular calcification associated with CKD. We examined the role of Klotho in cardiac remodeling in models of Klotho deficiencygenetic Klotho hypomorphism, high dietary phosphate intake, aging, and CKD. Klotho-deficient mice exhibited cardiac dysfunction and hypertrophy before 12 weeks of age followed by fibrosis. In wild-type mice, the induction of CKD led to severe cardiovascular changes not observed in control mice. Notably, non-CKD mice fed a high-phosphate diet had lower Klotho levels and greatly accelerated cardiac remodeling associated with normal aging compared with those on a normal diet. Chronic elevation of circulating Klotho because of global overexpression alleviated the cardiac remodeling induced by either high-phosphate diet or CKD. Regardless of the cause of Klotho deficiency, the extent of cardiac hypertrophy and fibrosis correlated tightly with plasma phosphate concentration and inversely with plasma Klotho concentration, even when adjusted for all other covariables. High-fibroblast growth factor-23 concentration positively correlated with cardiac remodeling in a Klotho-deficient state but not a Klotho-replete state. In vitro, Klotho inhibited TGF-b1-, angiotensin II-, or high phosphate-induced fibrosis and abolished TGF-b1-or angiotensin II-induced hypertrophy of cardiomyocytes. In conclusion, Klotho deficiency is a novel intermediate mediator of pathologic cardiac remodeling, and fibroblast growth factor-23 may contribute to cardiac remodeling in concert with Klotho deficiency in CKD, phosphotoxicity, and aging.

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“…69,70 For immunofluorescence, 1310 6 cells were seeded per well on glass coverslips in six-well plates. For protein and RNA isolation, 2310 6 cells were seeded in 6-cm culture dishes.…”

Section: Primary Culture Of Neonatal Rat Ventricular Myocytes and Carmentioning

confidence: 99%

Klotho and Phosphate Are Modulators of Pathologic Uremic Cardiac Remodeling

Hu¹,

Shi²,

Cho³

et al. 2015

Journal of the American Society of Nephrology

235

300

View full text Add to dashboard Cite

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“…Associated factors include hypertension, body mass index, type of peritoneal dialysis applied, anemia and hyperparathyroidism, as well as the etiology of CKD other than renal dysplasia 8,14,15 .…”

Section: Discussionmentioning

confidence: 99%

“…Values previously estimated by Mitsnefes with a more limited number of patients, found that LVMI was 68-73% in patients in PD 7 and 80-85% in patients in HD 7,16 . The collaborative study published by the IPPN found that the use of height-associated LVMI provides the most prevailing prevalence of LVH in patients with PD 8 .…”

Section: Discussionmentioning

confidence: 99%

“…According to the International Pediatric Peritoneal Dialysis Network (IPPN) 8 , the prevalence of LVH in children in PD reaches 40%. From these, an adequate dialytic control achieves a regression of up to 50% 9 .…”

Section: Introductionmentioning

confidence: 99%

“…Mitsnefes M. et al (10) reported a figure of 75%, and the IPPN registry showed that only 26% of PD patients had normal heart condition 8 . The NA-PRTCS 2008 Registry showed that, from 4,000 patients on dialysis, 57% were with uncontrolled hypertension (> 95%), confirming that in patients with PD, hypertension and cardiac damage are most frequently associated with LVH 7 .…”

Section: Introductionmentioning

confidence: 99%

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Compromiso cardiovascular en pacientes pediátricos en diálisis peritoneal crónica

2017

Rev. chil. pediatr.

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Peritoneal dialysis (PD) is the most common renal replacement therapy used in pediatric patients with end stage renal disease. This population has a mortality rate 1,000 times greater compare to pediatric population, mainly due to cardiovascular causes. Objective: To characterize pediatric patients on chronic PD in relation to dialysis and cardiovascular outcome. Patients and Methods: Cross sectional study. Patients in stable PD according to DOQI criteria were selected. Epidemiological, dialytic, biochemical and cardiovascular variables were registered. Left Ventricular Mass Index (LVMI) was calculated by height/age (g/m 2.7 ). Left Ventricular Hypertrophy (LVH) was diagnosed with > 38.6 g/m 2.7 , severe LVH > 51 g/m 2.7 . Data were analyzed using STATA 11.0. continuous variables using ANOVA test and categorical variables were analyzed using c 2 test or Fisher's exact test. Results: 21 patients, 11 males. Mean age 9.2 ± 3.52 years. The most frequent diagnosis was renal dysplasia (52%). Residual and Peritoneal KtV were 0.8 and 1.9 respectively. Fifty-two percent of patients showed LVH, 91% in severe range. A significant relationship between ultrafiltration/m2 and systolic blood pressure was depicted. Also a significant relationship between left ventricular mass index and hemoglobin (p < 0.05) was founded. Conclusions: The majority of the population showed left ventricular hypertrophy -particularly severe LVH-, which confirms an increased CV risk in this population. Blood pressure and loss of ultrafiltration were founded to be correlated to LVH.

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Interventions for metabolic bone disease in children with chronic kidney disease

Hahn

Hodson

Craig

2015

Cochrane Database of Systematic Reviews

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Background Bone disease is common in children with chronic kidney disease (CKD) and when untreated may result in bone deformities, bone pain, fractures and reduced growth rates. This is an update of a review first published in 2010. Objectives This review aimed to examine the benefits (improved growth rates, reduced risk of bone fractures and deformities, reduction in PTH levels) and harms (hypercalcaemia, blood vessel calcification, deterioration in kidney function) of interventions (including vitamin D preparations and phosphate binders) for the prevention and treatment of metabolic bone disease in children with CKD. Search methods We searched the Cochrane Kidney and Transplant Specialised Register to 8 September 2015 through contact with the Trial's Search Coordinator using search terms relevant for this review. Selection criteria We included randomised controlled trials (RCTs) comparing di erent interventions used to prevent or treat bone disease in children with CKD stages 2 to 5D. Data collection and analysis Data were assessed for study eligibility, risk of bias and extracted independently by two authors. Results were reported as risk ratios (RR) or risk di erences (RD) with 95% confidence intervals (CI) for dichotomous outcomes. For continuous outcomes the mean di erence (MD) or standardised mean di erence (SMD) with 95% confidence intervals (CI) was used. Statistical analyses were performed using the randome ects model. Main results This review included 18 studies (576 children); three new studies were added for this update. Adequate sequence generation and allocation concealment were reported in 12 and 11 studies respectively. Only four studies reported blinding of children, investigators or outcome assessors. Nine studies were at low risk of attrition bias and 12 studies were at low risk of selective reporting bias. Interventions for metabolic bone disease in children with chronic kidney disease (Review)

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Cardiac Geometry in Children Receiving Chronic Peritoneal Dialysis

Cited by 83 publications

References 35 publications

Klotho and Phosphate Are Modulators of Pathologic Uremic Cardiac Remodeling

Klotho and Phosphate Are Modulators of Pathologic Uremic Cardiac Remodeling

Compromiso cardiovascular en pacientes pediátricos en diálisis peritoneal crónica

Interventions for metabolic bone disease in children with chronic kidney disease

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