Cardiac glycosides from Yellow Oleander (Thevetia peruviana) seeds

Kohls, Sarah; Scholz‐Böttcher, Barbara M.; Teske, Jörg; Zark, Patrick; Rullkötter, Jürgen

doi:10.1016/j.phytochem.2011.11.019

Cited by 60 publications

(39 citation statements)

References 29 publications

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“…Cardiac glycosides were also isolated from the roots of Carissa carandas and characterized spectroscopically (FT‐IR, 1 H‐NMR, and 13 C‐NMR) as odoroside H, rhamnoside, rhamnoglycoside, and evomoside ( 80 – 83 ; Hegde et al, ) . Similarly, thevetin and acetylthevetin (84, 85) were isolated from the seeds of Thevetia peruviana (Kohls et al, ). Cardenolides, an important class of cardiac glycosides were found to be present in Nerium oleander and Thevetia peruviana .…”

Section: Phytochemistrymentioning

confidence: 99%

Ethnopharmacology, phytochemistry, and biotechnological advances of family Apocynaceae: A review

Bhadane¹,

Patil²,

Maheshwari

et al. 2018

Phytotherapy Research

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The family Apocynaceae is one of the largest and important families in angiosperm. Several members of this family have medicinal properties and have been in the treatment of various ailments. Most of them are consumed as food by tribal people whereas a few plants are used as source of poison. Members of family Apocynaceae are rich in alkaloids, terpenoids, steroids, flavonoids, glycosides, simple phenols, lactones, and hydrocarbons. Other compounds such as sterols, lignans, sugars, lignans, and lactones have been isolated and systematically studied. Few studies have reported antioxidant, anti-inflammatory, antimicrobial, and cytotoxic activities of crude extracts as well as single compound(s) isolated from various members of the family Apocynaceae. Holarrhena antidysenterica, Rauvolfia serpentina, Carissa carandas, and Tabernaemontana divaricata are the extensively studied plants in this family. The present review provides a detailed outlook on ethnopharmacology, phytochemistry, and biological activities of selected members of this family. Moreover, it also covers the biotechnological advances used for large-scale production of bioactive compounds of therapeutic interest along with plant tissue culture-based approaches for conservation of this medicinally valuable family.

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Section: Phytochemistrymentioning

confidence: 99%

Ethnopharmacology, phytochemistry, and biotechnological advances of family Apocynaceae: A review

Bhadane¹,

Patil²,

Maheshwari

et al. 2018

Phytotherapy Research

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“…[1213] Cardioactive glycoside such as thevetin A, thevetin B, neriifolin, peruvoside, thevetoxin, and ruvoside are found in T. peruviana . [14]…”

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confidence: 99%

Antifertility activity of Thevetia peruviana (Pers.) K. Schum leaf in female Sprague-Dawley rat

2016

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Objectives:Thevetia peruviana (Pers.) K. Schum. (Apocynaceae) is known to possess cardioactive glycoside such as thevetin A, thevetin B, neriifolin, peruvoside, thevetoxin, and ruvoside. Traditionally, T. peruviana leaves are used as abortifacient. The aim of the present study is to evaluate antifertility potential of T. peruviana leaves.Subjects and Methods:Cardiac glycoside freed leaves of T. peruviana were extracted with methanol using maceration method. The dried cardiac glycoside-free methanolic extract of T. peruviana leaves (TPL-Me-G) was screened for phytoconstituents and evaluated for its effect on estrogen-primed female Sprague-Dawley rat uterus model. It was further studied for effects on the estrous cycle, implantation, and effect on estrogen and progesterone.Statistical Analysis Used:Statistical analysis was done by ANOVA followed by Dunnett's t-test.Results:Alkaloids, flavonoids, essential oils, carbohydrates, and amino acids were found to be present in the glycoside-free extract. Thin-layer chromatography (TLC) in n-butanol: acetone: water (4:1:5) revealed the presence of quercetin and kaempferol. The presence of flavonoids (quercetin 0.0326% and kaempferol 0.138% on dry weight basis) was reconfirmed by high-performance TLC analysis. The extract was able to induce uterine contractions (EC50, 0.170 mg/ml) in a dose-dependent manner. Further investigation showed significant (P < 0.001) extension of estrous cycle and anti-implantation activity of the extract by reduction of the progesterone level.Conclusions:Methanolic extract of T. peruviana leaves (TPL-Me-G) containing quercetin 0.0326% and kaempferol 0.138% possesses a significant (P < 0.001) antifertility potential by virtue of decreasing the progesterone level.

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“…These results are consistent with those reported by previous research. Presence of cardiac glycosides in extracts of different parts of the in vivo plant (Gezahegn et al, 2015;Kohls et al, 2012;Mateus, 2012) as well as in vitro callus and suspension cultures (Alhashimi et al, 2013;Arias et al, 2010) had been reported. Other authors have detected presence of more families of secondary metabolites such as alkaloids, terpenoids, saponins, flavonoids and phenols (Arias et al, 2016;Bhoyar & Biradar, 2014;Gezahegn et al, 2015).…”

Section: Phytochemical Analysismentioning

confidence: 99%

Antimicrobial activity of callus and cell suspension cultures extracts of Thevetia peruviana

et al. 2019

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Thevetia peruviana is an ornamental plant considered as a source of biological compounds with cardiac and antimicrobial activity. These compounds are normally extracted from different parts of in vivo plants. In this work, extracts were obtained from in vitro callus and plant cell suspension cultures of T. peruviana and their antimicrobial activity was evaluated by disk diffusion tests against gram negative (Salmonella thipimurium and Escherichia coli) and gram positive (Staphylococcus aureus and Bacillus cereus) strains. Ethanol, methanol and hexane extracts from callus and cell suspension cultures showed biological activity. Methanolic cell suspension extract showed activity against B. cereus and S. aureus. Ethanolic cell suspension extract inhibit all the bacteria, especially S. thipimurium while hexanic extract showed resistance activity against S. thipimurium, S. aureus and B. cereus. In terms of the source of the extracts, hexane extracts obtained from cell suspension cultures showed a higher antimicrobial activity than callus, while ethanol extracts had an inverse behavior. These results outline in vitro cell culture of T. peruviana as a feasible biotechnological platform for the production of compounds with antimicrobial activity.. KEYWORDS: Antimicrobial activity; callus culture; plant cell suspension culture; Thevetia peruviana. RESUMEN: Thevetia peruviana es una planta ornamental considerada fuente de compuestos biológicos con actividad cardiotónica y antimicrobiana extraídos normalmente de diferentes partes de la planta. En este trabajo se obtuvieron extractos a partir de cultivos de callos y suspensiones celulares de T. peruviana y se evaluó su actividad antimicrobiana mediante pruebas de difusión en disco contra cepas gram negativas (Salmonella thipimurium y Escherichia coli) y gram positivas (Staphylococcus aureus y Bacillus cereus). Los extractos de etanol, metanol y hexano de cultivos de callos y suspensiones celulares mostraron actividad biológica. El extracto de metanol de la suspensión celular mostró a Arias, J. P.; Ortega, I.; Peñuela, M. & Arias, M. (2018). Antimicrobial activity of callus and cell suspension cultures extracts of Thevetia peruviana. Rev. Fac. Cienc., 8(1), 45-56.

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Cardiac glycosides from Yellow Oleander (Thevetia peruviana) seeds

Cited by 60 publications

References 29 publications

Ethnopharmacology, phytochemistry, and biotechnological advances of family Apocynaceae: A review

Ethnopharmacology, phytochemistry, and biotechnological advances of family Apocynaceae: A review

Antifertility activity of Thevetia peruviana (Pers.) K. Schum leaf in female Sprague-Dawley rat

Antimicrobial activity of callus and cell suspension cultures extracts of Thevetia peruviana

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