Cardiac imaging using 256-detector row four-dimensional CT: preliminary clinical report

Kido, Teruhiko; Kurata, Akira; Hara, Hiroshi; Sugawara, Yumi; Okayama, Hideki; Higaki, Jitsuo; Anno, Hirofumi; Katada, Kazuhiro; Mori, Shinichiro; Tanada, Shuji; Endo, Masahiro; Mochizuki, Takashi

doi:10.1007/s11604-006-0097-z

Cited by 65 publications

(38 citation statements)

References 21 publications

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“…Increasing the number of detector rows facilitates faster, higher-resolution imaging and larger fields of view, and 16-, 32-, 64-, 256-, and 320-row detector and dual-source systems are in clinical use. 200,201 Slower image acquisition by equipment with fewer detector rows allows the intravenous contrast bolus to traverse the arteries and enter the capillaries and veins before imaging is complete, degrading images by competing enhancement of these structures. Conversely, scanners with a greater number of detector rows offer faster acquisition during the arterial phase, reduce motion and respiratory artifacts, and lessen the volume of contrast required.…”

Section: Computed Tomographic Angiographymentioning

confidence: 99%

2011 ASA/ACCF/AHA/AANN/AANS/ACR/ASNR/CNS/SAIP/SCAI/SIR/SNIS/SVM/SVS Guideline on the Management of Patients With Extracranial Carotid and Vertebral Artery Disease

Brott¹,

Halperin²,

Abbara

et al. 2011

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143

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Section: Computed Tomographic Angiographymentioning

confidence: 99%

2011 ASA/ACCF/AHA/AANN/AANS/ACR/ASNR/CNS/SAIP/SCAI/SIR/SNIS/SVM/SVS Guideline on the Management of Patients With Extracranial Carotid and Vertebral Artery Disease

Brott¹,

Halperin²,

Abbara

et al. 2011

Stroke

143

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“…New CT technology has moved toward more detector rows, which is an advantage for gated imaging applications such as in cardiology. Currently, the state of the art is a 64-slice CT system that can obtain a whole-body scan within a single breath-hold and allows cardiac imaging (56)(57)(58)(59)(60)(61), acquiring more than 150 slices per second at a resolution below 0.5 mm. In clinical studies, devices acquiring up to 256 slices per rotation are currently under investigation (60).…”

Section: Ct and Pet/ctmentioning

confidence: 99%

Latest Advances in Molecular Imaging Instrumentation

Pichler¹,

Wehrl²,

Judenhofer³

2008

J Nucl Med

194

110

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This review concentrates on the latest advances in molecular imaging technology, including PET, MRI, and optical imaging. In PET, significant improvements in tumor detection and image resolution have been achieved by introducing new scintillation materials, iterative image reconstruction, and correction methods. These advances enabled the first clinical scanners capable of time-of-flight detection and incorporating point-spread-function reconstruction to compensate for depth-of-interaction effects. In the field of MRI, the most important developments in recent years have mainly been MRI systems with higher field strengths and improved radiofrequency coil technology. Hyperpolarized imaging, functional MRI, and MR spectroscopy provide molecular information in vivo. A special focus of this review article is multimodality imaging and, in particular, the emerging field of combined PET/MRI. PETi s a high-performance imaging technology that can image the whole-body distribution of positron-emitting biomarkers with high sensitivity. The invention of PET dates back more than 30 y. However, the acceptance of PET as a routine clinical diagnostic tool has been hampered by the need for an on-site cyclotron and a radiochemistry unit for the production of the short-lived radiotracers (1-7). With the availability of commercial radiopharmacies that supply PET probes and with the relatively broad insurance coverage for a variety of clinical indications, the number of PET centers now totals more than 2,000 worldwide.Major technologic milestones in the development of PET include the discovery of faster and brighter scintillators such as lutetium oxyorthosilicate (LSO), gadolinium oxyorthosilicate, and lutetium yttrium oxyorthosilicate. Furthermore, the continuing development of the detectors, progressing from one-to-one scintillator-to-photomultiplier-tube (PMT) coupling (8,9) to advanced block and Anger readout schemes, helps to limit the costs of a PET scanner by providing a multiplexed readout and reduced electronic channels (10-13).The use of faster scintillators enabled the transition from 2-dimensional data acquisitions for whole-body PET, using lead or tungsten collimators as septa (14-16), to 3-dimensional (3D) acquisitions (17). However, approximately an 8-fold increase in detection sensitivity is accompanied by an increased fraction of random and scattered photon events leading to degradation of image quality if not corrected during image reconstruction (18). This degradation effectively reduces the increase in sensitivity from a factor of 8 to approximately 5-fold. To achieve high-quality and quantitative PET data, various image reconstruction techniques have evolved (19). One simple approach is filtered backprojection, which is computationally fast but results in poor image quality if the count statistics of the available PET data are inadequate. Better image quality and improved spatial resolution are achieved by iterative methods such as ordered-subset expectation maximization or maximumlikelihood expectation maximiza...

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“…32 Of course, caution will be needed with the increased radiation dose required. Flow reserve is usually assessed by comparing stress MBF with rest levels.…”

Section: Discussionmentioning

confidence: 99%

Quantification of Regional Myocardial Blood Flow Using First-Pass Multidetector-Row Computed Tomography and Adenosine Triphosphate in Coronary Artery Disease

Kido

Kurata

Hara

et al. 2008

Circ J

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lectrocardiography (ECG)-gated multidetector-rowcomputed tomography (MDCT) has developed remarkably in the past several years, with improvements in spatial and temporal resolution. [1][2][3] Several studies have focused on its usefulness for assessing the coronary artery lumen, and others studies have demonstrated its capability to evaluate coronary plaques, so the technique has gained acceptance as a valuable tool for coronary imaging in the clinical setting. [4][5][6][7][8][9][10][11] Because of the retrospective acquisition, the same data acquired for coronary computed tomography (CT) imaging can also be reconstructed over a cardiac cycle, allowing dynamic cardiac imaging; and we recently reported that wall motion and systolic thickening could be accurately estimated as functional parameters. 12-14 ECG-gated MDCT technology can therefore evaluate cardiac blood flow from virtually any perspective, including important angles for the interventional approach and for myocardial perfusion.Of these potential applications of cardiac MDCT, myocardial perfusion has so far been less investigated, but its assessment is important for the diagnosis of ischemia and infarction, and for the therapeutic strategy and follow-up. An evaluation of myocardial blood flow (MBF) is also important for studying the pathophysiology of the disease process. A few studies have reported the utility of cardiac MDCT to qualitatively assess myocardial perfusion using a late-enhancement protocol and the adenosine triphosphate (ATP) load technique, [15][16][17][18][19] but quantitative evaluation studies have not been carried out.Therefore, in this study, we investigated the feasibility of cardiac MDCT technology for quantitative assessment of MBF using the ATP-load technique. Methods PatientsFrom April 2006 to May 2007, taking the exclusion criteria into account, 14 patients (11 men, 3 women, age range 52-79 years, mean 69.2 years) underwent ATP-provocation contrast enhanced MDCT, stress thallium-201 myocardial perfusion scintigraphy (MPS), and conventional coronary angiography (CAG). The entry criteria were: (i) de novo effort or rest angina (documented ST-T change on ECG, or relieved by administration of nitroglycerin); (ii) no history of CAG; and (iii) asymptomatic patients with a high probability of coronary artery disease (CAD) (ie, multiple coronary risk factors) or abnormal findings on stress ECG and single-photon emission computed tomography (SPECT). The ATP-load cardiac CT and CAG had an average 40-day interval, and the ATP-load cardiac CT and MPS inspection had an average interval of 29.2 days. Patient characteristics are shown in Table 1. No patient had a history of previous myocardial infarction (MI) and there were no significant differences between men and women in age, clinical symptoms and coronary risk factors.Circ J 2008; 72: 1086 -1091 (Received November 21, 2007; revised manuscript received February 5, 2008; accepted February 7, 2008

show abstract

Cardiac imaging using 256-detector row four-dimensional CT: preliminary clinical report

Abstract: The 256-detector row four-dimensional CT can assess the coronary artery and cardiac function using data during 1.5 s without banding artifacts.

Cited by 65 publications

References 21 publications

2011 ASA/ACCF/AHA/AANN/AANS/ACR/ASNR/CNS/SAIP/SCAI/SIR/SNIS/SVM/SVS Guideline on the Management of Patients With Extracranial Carotid and Vertebral Artery Disease

2011 ASA/ACCF/AHA/AANN/AANS/ACR/ASNR/CNS/SAIP/SCAI/SIR/SNIS/SVM/SVS Guideline on the Management of Patients With Extracranial Carotid and Vertebral Artery Disease

Latest Advances in Molecular Imaging Instrumentation

Quantification of Regional Myocardial Blood Flow Using First-Pass Multidetector-Row Computed Tomography and Adenosine Triphosphate in Coronary Artery Disease

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