Cardiac Inflammatory Myofibroblastic Tumor in a Young Male Patient With Myopericarditis

Blanco, Miriam; Fulquet, Enrique; Laguna, Gregorio; Martínez, Gerardo; Sevilla, Teresa; Stefano, Salvatore Di; Ortega, Christian

doi:10.1161/circulationaha.115.018671

Cited by 4 publications

(4 citation statements)

References 3 publications

(3 reference statements)

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“…Cases of IMT associated with pericardial tamponade are few. Other patients with pericardial involvement were young adults [12]. The present case is the youngest to present with pericardial tamponade.…”

Section: Discussionmentioning

confidence: 57%

Intrapericardial inflammatory myofibroblastic tumour in a 3-month-old infant associated with Coronavirus OC43 presenting with pericardial tamponade

Donmez

Aykan

Orhan

et al. 2020

Paediatrics and International Child Health

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Inflammatory myofibroblastic tumour usually has a benign course and is very rarely associated with the heart. It can have life-threatening consequences, depending on its position or the presence of aggressive and metastatic complications. A 3-month-old boy presented with pericardial tamponade and was diagnosed with intrapericardial inflammatory myofibroblastic tumour associated with Coronavirus OC43. A large tumour attached to the left ventricle was completely removed by surgical resection and he made a full recovery.

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Section: Discussionmentioning

confidence: 57%

Intrapericardial inflammatory myofibroblastic tumour in a 3-month-old infant associated with Coronavirus OC43 presenting with pericardial tamponade

Donmez

Aykan

Orhan

et al. 2020

Paediatrics and International Child Health

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“…We performed a PubMed search to identify any related articles using the key words “inflammatory myofibroblastic tumor” and “cardiac tamponade.” We only found one case report by Agarwala et al; however, in that case, the cause of tamponade was pus due to purulent pericarditis, not IMT ( 8 ). An additional article reported by Blanco et al was identified by a manual search ( 9 ). Their 18-year-old patient showed cardiac tamponade with pain, a fever, leukocytosis, elevated cardiac enzymes, and second-degree atrioventricular block, requiring subxifoid pericardiocentesis, which resulted in drainage of a cloudy liquid.…”

Section: Discussionmentioning

confidence: 99%

“…The most common single clinical presentation was cardiac (19.3%), which included chest pain, heart failure, myocardial ischemia, murmur, and/or arrhythmia ( 10 ). A constitutional presentation (a fever, lethargy, weight loss, malaise, myalgia, and/or decreased appetite) alone or in combination with another presentation occurred most frequently (32.7%) ( 9 ). We were unable to investigate any complaints before collapse in the present case.…”

Section: Discussionmentioning

confidence: 99%

Fatal Cardiac Tamponade Due to a Pericardial Inflammatory Myofibroblastic Tumor

et al. 2022

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The patient was a 34-year-old woman who suddenly collapsed. On arrival, she was in cardiac arrest. Cardiac ultrasound revealed cardiac tamponade; thus, urgent thoracotomy with pericardiotomy was performed. Spontaneous circulation was temporarily obtained; however, her circulation was not stabilized, and she ultimately died. An autopsy revealed a pericardial inflammatory myofibroblastic tumor (IMT) causing bloody cardiac tamponade. There were no signs of cardiac rupture, myocardial infarction or aortic dissection. We reported the first case of fatal bloody cardiac tamponade due to pericardial IMT in an adult. An autopsy is important for clarifying the etiology in cases of fatal cardiac tamponade of unknown cause.

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“…The clinical manifestations of IMT are closely related to the site of the primary tumor. Known IMT symptoms are pain [ 32 ], fever [ 33 , 34 ], decreased appetite [ 34 , 35 ], weight loss [ 33 , 36 ], fatigue, and malaise [ 28 ]. Pulmonary IMT can cause productive or dry cough [ 34 ], chest pain [ 29 ], dyspnea [ 14 ], and hemoptysis [ 37 , 38 ].…”

Section: Introductionmentioning

confidence: 99%

Inflammatory myofibroblastic tumor from molecular diagnostics to current treatment

CHMIEL,

SłOWIKOWSKA,

BANASZEK

et al. 2024

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Inflammatory myofibroblastic tumor (IMT) is a rare neoplasm with intermediate malignancy characterized by a propensity for recurrence but a low metastatic rate. Diagnostic challenges arise from the diverse pathological presentation, variable symptomatology, and lack of different imaging features. However, IMT is identified by the fusion of the anaplastic lymphoma kinase (ALK) gene, which is present in approximately 70% of cases, with various fusion partners, including ran-binding protein 2 (RANBP2), which allows confirmation of the diagnosis. While surgery is the preferred approach for localized tumors, the optimal long-term treatment for advanced or metastatic disease is difficult to define. Targeted therapies are crucial for achieving sustained response to treatment within the context of genetic alteration in IMT. Crizotinib, an ALK tyrosine kinase inhibitor (TKI), was officially approved by the US Food and Drug Administration (FDA) in 2020 to treat IMT with ALK rearrangement. However, most patients face resistance and disease progression, requiring consideration of sequential treatments. Combining radiotherapy with targeted therapy appears to be beneficial in this indication. Early promising results have also been achieved with immunotherapy, indicating potential for combined therapy approaches. However, defined recommendations are still lacking. This review analyzes the available research on IMT, including genetic disorders and their impact on the course of the disease, data on the latest targeted therapy regimens and the possibility of developing immunotherapy in this indication, as well as summarizing general knowledge about prognostic and predictive factors, also in terms of resistance to systemic therapy.

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Cardiac Inflammatory Myofibroblastic Tumor in a Young Male Patient With Myopericarditis

Abstract: The online-only Data Supplement is available with this article at http://circ.ahajournals.org/lookup/suppl

Cited by 4 publications

References 3 publications

Intrapericardial inflammatory myofibroblastic tumour in a 3-month-old infant associated with Coronavirus OC43 presenting with pericardial tamponade

Intrapericardial inflammatory myofibroblastic tumour in a 3-month-old infant associated with Coronavirus OC43 presenting with pericardial tamponade

Fatal Cardiac Tamponade Due to a Pericardial Inflammatory Myofibroblastic Tumor

Inflammatory myofibroblastic tumor from molecular diagnostics to current treatment

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