Cardiac involvement in progressive muscular dystrophy

Weisenfeld, Shirley; Messinger, William J.

doi:10.1016/0002-8703(52)90209-3

Cited by 88 publications

(18 citation statements)

References 3 publications

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“…The cells were conspicously variable in size and showed clear degenerative changes, i.e., vacuolation, fragmentation, loss of striation and either hypertrophy or atrophy. These changes are similar to the findings which NOTHACKER andNETSKY (1950) andWEISENFELD andMESSINGER (1952) observed in dystrophic ventricles. Furthermore, the present electron microscopic observation demonstrated swollen mitochondria, swollen tubules of the sarcoplasmic reticulum, hypercontracted myofibrils and partially separated intercalated discs in the atrial cardiocytes.…”

Section: Discussionsupporting

confidence: 90%

Myocardial lesions and the alteration of atrial granularity in dystrophic mice.

Nomura

Mizukawa

Otsuka

1987

Arch. Histol. Jap., Arch. Histol. Jpn

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Section: Discussionsupporting

confidence: 90%

Myocardial lesions and the alteration of atrial granularity in dystrophic mice.

Nomura

Mizukawa

Otsuka

1987

Arch. Histol. Jap., Arch. Histol. Jpn

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“…abnormalities have been reported in patients with Duchenne muscular dystrophy (Lowenstein et al., 1962), but the most frequent and consistent abnormality is the presence of tall R waves in the right precordial leads (Weisenfeld and Messinger, 1952;Schott et al, 1955;Gailani et al, 1958;Manning and Cropp, 1958 ;Gilroy et al, 1963 ;Perloff et al, 1966Perloff et al, , 1967Jedrzejowska-Kulakowska et al, 1968;Slucka, 1968) resulting in an abnormally high value for the algebraic sum of the R and S waves (R-S) in V1 (Skyring and McKustick, 1961). This abnormality in the E.C.G.…”

Section: Introductionmentioning

confidence: 89%

Abnormalities of the Electrocardiogram in Female Carriers of Duchenne Muscular Dystrophy

Emery¹

1969

BMJ

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Summary: The algebraic sum of the R and S waves (R-S) in the V1 lead of the electrocardiogram has been found to be significantly greater in female carriers of X-linked Duchenne muscular dystrophy (but not in women with limb-girdle muscular dystrophy) compared with normal women of comparable age. A similar E.C.G. abnormality is found in affected boys, and possibly certain carriers have a latent cardiomyopathy and may even be predisposed to cardiac failure.

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“…It has generally been difficult to associate the accounts of heart disease with specific types of systemic myopathy since the term "progressive muscular dystrophy" has usually been applied as an overall designation without attempting to subdivide patients into the various clinical groups." [10][11][12][13][14][15][16][17][18][19] Furthermore, the different forms of muscular dystrophy resemble each other histologically.9' 20 Biopsy, therefore, cannot be depended upon to separate one from the other. Reviews have been limited by employing retrospective analyses of hospital case records'0 or by depending upon published reports of incompletely classified cases.'…”

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confidence: 99%

The Cardiomyopathy of Progressive Muscular Dystrophy

1966

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A prospective study was undertaken in order to examine the histories, physical signs, phonocardiograms, electrocardiograms, vectorcardiograms, X-rays, serum enzymes, pulmonary ventilatory findings, and hemodynamics in a group of 55 patients selected solely on the basis of one of the major types of progressive muscular dystrophy (table 9). The classification included: (1) the classic Duchenne type, (2) the limb girdle type, (3) the facioscapulohumeral type, and (4) a group of patients in whom clinical distinction between benign Duchenne dystrophy and limb girdle dystrophy with pseudohypertrophy could not be made. No patient had recognized heart disease prior to selection. Follow-up periods ranged from a few months to 5 years. The pertinent literature was extensively reviewed. In all groups clinical evidence of heart disease had to be interpreted in the context of the influence of the somatic musculoskeletal defects on "cardiac" symptoms, cardiovascular physical signs, and radiological appearance of the heart. On the other hand, convincing evidence of intrinsic heart disease-subtle to overt-was found in each of the major categories of progressive muscular dystrophy. Detection of cardiomyopathy was simplest and most frequent in the classic Duchenne group because of the highly characteristic features of the scalar electrocardiogram which might direct attention to the systemic myopathy prior to its clinical recognition. However, the presence of heart disease in patients with forms of dystrophy other than the classic Duchenne deserves particular emphasis. Evidence of cardiomyopathy in these latter forms varied from subtle quadruple gallop rhythms in the limb girdle and facioscapulohumeral groups to cardiomyopathic death in the benign Duchenne and limb girdle-pseudohypertrophic group. Currently available information on the heart in muscular dystrophy has as a rule depended upon retrospective studies, upon reviews of published reports of incompletely classified cases, upon discussions of individual cardiovascular features, or upon observations of individual types of dystrophy. The present prospective study was undertaken to obviate some of these shortcomings. Comprehensive assessment of a large and carefully classified group of dystrophic subjects has provided additional information regarding the clinical spectrum of dystrophic cardiomyopathy.

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Cardiac involvement in progressive muscular dystrophy

Cited by 88 publications

References 3 publications

Myocardial lesions and the alteration of atrial granularity in dystrophic mice.

Myocardial lesions and the alteration of atrial granularity in dystrophic mice.

Abnormalities of the Electrocardiogram in Female Carriers of Duchenne Muscular Dystrophy

The Cardiomyopathy of Progressive Muscular Dystrophy

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