Cardiac lesions after mediastinal irradiation for Hodgkin's disease

Glanzmann, Christoph; Huguenin, P; Um, Lütolf; Maire, R; Jenni, Rolf; Gumppenberg, V.

doi:10.1016/0167-8140(94)90008-6

Cited by 95 publications

(44 citation statements)

References 29 publications

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“…Wady zastawkowe wywołane przez napromienienie są coraz częściej wykrywanym schorzeniem występującym późno po radioterapii śródpiersia, a mediana czasu do rozpoznania wynosi 22 lata [306]. W 20-letniej obserwacji jedynie u mniejszości pacjentów obserwuje się całkowicie prawidłowo funkcjonującą zastawkę aortalną.…”

Section: Wady Zastawkoweunclassified

2016 ESC Position Paper on cancer treatments and cardiovascular toxicity developed under the auspices of the ESC Committee for Practice Guidelines

Zamorano¹,

Lancellotti²,

Muñoz³

et al. 2016

Kardiol Pol

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Section: Wady Zastawkoweunclassified

2016 ESC Position Paper on cancer treatments and cardiovascular toxicity developed under the auspices of the ESC Committee for Practice Guidelines

Zamorano¹,

Lancellotti²,

Muñoz³

et al. 2016

Kardiol Pol

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“…Immunsuppresive and wide spectrum antibiotics treatments [3] can result in bacterial or fungal endecarditis. Coronary artery lesions, constrictive pericarditis, valvular thickening and regurgitation are the unwanted side effects of radiotheraphy [4,5] ; and also dilate cardiomyopathy can be developed due to toxicity of the chemotherapeutics [6] In our case, there was a huge left atrial thrombus due to primary disease and an overlapping aspergillus endocarditis due to immunosupressive theraphy.…”

Section: Discussionmentioning

confidence: 99%

Huge left atrial thrombus infected with aspergillusfumigatus

Kızıltunç

Taçoy

Aki

2014

IJDI

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Twenty three year old man with Hodgkin lymphoma had a resistant fever although treatment with broad spectrum antibiotics. Transthoracic echocardiography was performed to explain the origin of the fever and a huge mass was detected in the left atrium. Cardiac magnetic resonance imaging was performed and reported as intracardiac thrombus. Patient was referred to surgery. Culture of the surgical material favored to Aspergillus fumigates. Voriconazole treatment was started and patient recovered. The authors report overlapping two different clinical situations, intracardiac thrombus and fungal infective endocarditis.

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“…[60] In Dutch HL survivors treated with mediastinal radiation, the 20-year cumulative risk of myocardial infraction was 21.2%. [61] In a similar cohort Aleman et al reported the risk of development of a myocardial infarction at 30 years post-radiation was 12.4%. [62] The selection of chemotherapy, including the use of anthracyclines, does not appear to definitively impact risks of CAD among survivors.…”

Section: Cardiovascular Toxicitiesmentioning

confidence: 90%