Cardiac Lymph in Electrical Ventricular Fibrillation: An Experimental Study

Taira, Akira; Yamashita, Masafumi; Arikawa, K; Hamada, Y; Toyohira, H; Akita, Hachinen

doi:10.1016/s0003-4975(10)63256-0

Cited by 11 publications

(6 citation statements)

References 11 publications

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“…It has been shown that cardiac arrest significantly decreases myocardial lymph flow and impairs lymph drainage, thus leading to water accumulation in the interstitial compartment. 9,10,25,26 Decreased lymph flow and driving pressure were observed during ventricular fibrillation, while normal coronary perfusion was maintained. 10,25 This suggests that organized myocardial contraction is very important for maintenance of normal myocardial lymph flow and myocardial fluid homeostasis.…”

Section: Discussionmentioning

confidence: 99%

“…9,10,25,26 Decreased lymph flow and driving pressure were observed during ventricular fibrillation, while normal coronary perfusion was maintained. 10,25 This suggests that organized myocardial contraction is very important for maintenance of normal myocardial lymph flow and myocardial fluid homeostasis. 10,25 In addition, as a result of prolonged diastolic cardiac arrest, myocardial microvascular filtration was increased, thus leading to the development of myocardial edema during cardioplegia.…”

Section: Discussionmentioning

confidence: 99%

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Keeping the heart empty and beating improves preservation of hypertrophied hearts for valve surgery

Wang

Liu

Xiang

et al. 2006

The Journal of Thoracic and Cardiovascular Surgery

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Keeping the heart empty and beating improves preservation of hypertrophied hearts for valve surgery

Wang

Liu

Xiang

et al. 2006

The Journal of Thoracic and Cardiovascular Surgery

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show abstract

“…128,129 This is consistent with forms of lymph propulsion that are independent of cardiac contraction. 126,128,[130][131][132] It is also possible that impaired cardiac lymph flow can participate in several forms of cardiac pathology, such as dilated cardiomyopathy (DCM) and heart failure. 127,133,134 Inflammatory myocarditis provokes myocardial edema, and formation of inflammatory infiltrates of lymphocytes and macrophages; both can drive underlying lymphatic pumping disturbances.…”

Section: -125mentioning

confidence: 99%

Anatomy and roles of lymphatics in inflammatory diseases

Al‐Kofahi

Yun

Minagar

et al. 2017

Clinical & Exp Neuroim

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The lymphatic system maintains tissue homeostasis by transporting interstitial fluid, lipids and debris from tissues to the main circulation, and delivers antigen and antigen presenting cells to local lymph nodes where they elicit immune responses. During inflammation, lymph flow increases to limit edema and prevents tissue antigen-presenting cell transport. Lymphatics also adjust their contractile activity to increase fluid transfer during acute inflammation. Conversely, chronic inflammation can provoke lymphostasis, which might limit pathogen spread within the circulation; however, decreased lymph flow leads to the persistence of immune cells and mediators in tissues to intensifying injury. Here, we review lymphatic structure function within the gut, heart and central nervous system, discussing potential roles of these lymphatics in the etiology of inflammatory bowel disease, myocarditis and neurovascular disease, and as novel targets for therapeutic management of several disease states.

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Section: Discussionmentioning

confidence: 99%

“…This technique, at sufficient blood flow, sustained normal myocardial energy metabolism in hypertrophied hearts. Among others, we believe that the beneficial effects of the beating-heart approach over cardioplegic arrest are related to preservation of normal lymphatic flow [26][27][28][29] and prevention of inward movement of potassium chloride. 30,31 Beginning in 2001, this method of myocardial protection was utilized in clinical practice in a series of patients undergoing cardiac valve and aortic root operations.…”

Section: Discussionmentioning

confidence: 99%

Surgery for Cardiac Valves and Aortic Root Without Cardioplegic Arrest ("Beating Heart"): Experience with a New Method of Myocardial Perfusion

et al. 2007

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Simultaneous antegrade/retrograde warm blood perfusion with a beating heart has not been previously reported as a mean of protecting hypertrophied hearts in cardiac valve and aortic root surgeries. Similarly, beating heart mitral valve surgery via the trans-septal approach with the aorta unclamped, is a novel technique. We, herein, report a series of 346 patients with a variety of cardiac pathologies who were operated upon utilizing a new modality of myocardial perfusion. Among this group of patients, there were 55 patients who were diagnosed with endocarditis of one or more valves. These patients were excluded from this series of patients. Mean age was 59 +/- 12, and there were 196 (67.3%) males and 95 (32.7%) females. There were six aortic root procedures, 90 mitral valve replacements (MVR), 46 mitral valve repairs, 20 MVR+ coronary artery bypass grafting (CABG), 28 tricuspid valve repairs, 106 aortic valve replacements (AVR), 17 AVR+CABG, and 8 AVR/MVR. Crude mortality for the group was 20 of 291 (6.8%). Intra-aortic balloon pump utilization at time of weaning from cardiopulmonary bypass was 6/291 (2.06%), and re-operation for bleeding was needed in 12 of 291 (4.1%) patients. Postoperative stroke occurred in 4 of 291 (1.3%) patients. In these patients, the clinical diagnosis of stroke was made prior to surgery. This initial experience with this new method of myocardial perfusion indicates that results are at least comparable, if not superior, to conventional techniques utilizing intermittent cold blood cardioplegia.

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Cardiac Lymph in Electrical Ventricular Fibrillation: An Experimental Study

Cited by 11 publications

References 11 publications

Keeping the heart empty and beating improves preservation of hypertrophied hearts for valve surgery

Keeping the heart empty and beating improves preservation of hypertrophied hearts for valve surgery

Anatomy and roles of lymphatics in inflammatory diseases

Surgery for Cardiac Valves and Aortic Root Without Cardioplegic Arrest ("Beating Heart"): Experience with a New Method of Myocardial Perfusion

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