Cardiac Lymphoma Associated with Superior Vena Caval Syndrome and Cardiac Tamponade: Case History

Hwang, Ming H.; Brown, Alan; Piao, Zhen En; Scanlon, Patrick J.

doi:10.1177/000331979004100410

Cited by 18 publications

(10 citation statements)

References 7 publications

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“…In chemotherapy-related death, massive lymphomainfiltration tends to appear as regions ofnecrosis or lacking cellular components, and microscopic infiltration is often difficult to detect in postmortem examinations. Accordingly, the subclinical organ involvement that was well documented in the past may be missed by autopsies conducted currently (10). This may explain the discrepancy between the experience of clinicians and pathologists.…”

Section: Treatmentmentioning

confidence: 99%

“…Echocardiography and computedtomography with bolus enhancement (19) are both useful for identifying tumors involving the cardiac chambers orthe greatvessels (6,10,12,13,20), as well as for demonstrating lymphadenopathy and related abnormalities (7,20). Magnetic resonance imaging with the spin-echo method may also be suitable for defining any macroscopic abnormalities of the cardiovascular system (21).…”

Section: Cardiac Manifestationsmentioning

confidence: 99%

“…However, emergency irradiation (6,8,10), drainage ofa pericardial effusion (6-1 1), or surgical tumor removal (12) may be appropriate under certain circumstances. Constrictive or obstructive lesions appear to be at least partially controlled by irradiation (12) and/or standard regimens of combination chemotherapy (6-10, 15, 23).…”

Section: Treatmentmentioning

confidence: 99%

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Non-Hodgkin's Malignant Lymphoma of the Bone with Intracavitary Cardiac Involvement.

Satô

Takahashi

1993

Intern. Med.

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An 84-year-old man with non-Hodgkin's malignant lymphomapresented with a pathological fracture of the femur and also an intra-atrial mass on echocardiography. The patient was given palliative low-dose chemotherapy, but died of tumor dissemination, hypercalcemia, and dehydration. Autopsy revealed diffuse large B-cell lymphoma involving multiple bones and lymph nodes (the latter were not detected during staging), and a solitary mass on the posterior wall of the right atrium. This rare lesion appeared to be due to hematogenousspread, since the myocardiumand pericardium were free of tumor infiltration. A literature review indicated that the frequency of cardiac involvement differed between contemporary and earlier reports, mainly due to the availability of increasingly sophisticated diagnostic methods and improvements in chemotherapy. (Internal Medicine 32: 502-507, 1993)

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Section: Treatmentmentioning

confidence: 99%

Section: Cardiac Manifestationsmentioning

confidence: 99%

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Non-Hodgkin's Malignant Lymphoma of the Bone with Intracavitary Cardiac Involvement.

Satô

Takahashi

1993

Intern. Med.

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“…It is an extranodal lymphoma involving only the heart and/or the pericardium [5]. We report 3 cases of primary cardiac lymphoma and review 35 cases from the literature [1,2,3,6,7,8,9,10,11,12,15,17,18,19,20,21,22,23,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,41].…”

Section: Introductionmentioning

confidence: 99%

Primary cardiac lymphoma in immunocompetent patients: a report of three cases and review of the literature

et al. 2002

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Primary cardiac lymphoma is an extranodal non-Hodgkin's lymphoma exclusively located in the heart and/or pericardium, extremely rare in immunocompetent patients, and more frequent in immunodepressed patients. We present 3 retrospectives cases of primary cardiac lymphoma in immunocompetent patients and review 35 cases reported in the literature. Two patients were adults and one was a child. Primary cardiac lymphoma presented with constitutional symptoms in two cases and superior vena caval syndrome in one case. Diagnosis of a tumor mass was made in all cases by transthoracic echocardiography. Primary cardiac lymphoma arose in the heart right chambers in two cases. Histological diagnoses, obtained after thoracotomy, were diffuse large B-cell lymphoma in two cases, and Burkitt's lymphoma in one case. All three cases received chemotherapy, combined with radiotherapy in one patient. Of our patients, 2 are alive and asymptomatic 12 months and 33 months after diagnosis. In conclusion, diagnosis of primary cardiac lymphoma is difficult due to non-specific clinical manifestations and should be considered in patients with a cardiac mass sometimes with pericardial effusion. It is confirmed using transthoracic echocardiography and magnetic resonance imaging and certified using cytology or open biopsy. The only effective treatment is chemotherapy, but prognosis remains poor.

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“…La exéresis tumoral generalmente es impracticable debido a la infiltración difusa del tejido cardiaco. La poliquimioterapia ha sido empleada obteniéndose escasas remisiones completas (8)(9)(10)(11). No obstante, en algunos casos en que se ha podido establecer un diagnóstico precoz la poliquimioterapia intensiva ha permitido mejorar el pronóstico (6,7,12).…”

Section: Discussionunclassified

Linfoma cardiaco primario: Presentación de dos casos en pacientes inmunocompetentes

Artal

Roure

Ferré

et al. 2002

An. Med. Interna (Madrid)

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INTRODUCCIÓNEl linfoma cardiaco primario (LCP) es una forma muy infrecuente de presentación de linfoma extranodal (1). Los pacientes suelen presentar insuficiencia cardiaca y derrame pericárdico, y con frecuencia se afectan las cavidades cardiacas derechas. Los métodos más sensibles para diagnosticar este tumor son la resonancia magnética y la ecocardiografía transesofágica . Histológicamente los LCPs son, en la mayoría de casos, linfomas B de células grandes difusos (2). El pronóstico es grave debido a la localización del tumor. El virus de Epstein-Barr (VEB) ha sido descrito como agente causal de LCP en pacientes inmunodeprimidos (3). No obstante no se ha demostrado la relación del VEB como agente causal de LCP en pacientes inmunocompetentes.En el presente trabajo se describen las características clíni-cas de dos pacientes inmunocompetentes afectos de LCP. Se ha investigado la presencia de VEB en el tumor mediante hibridación in situ e inmunohistoquímica. CASOS APORTADOSCaso 1: Una mujer de 49 años de edad, sin antecedentes patoló-gicos de interés, presentaba un cuadro de dolor en hipocondrio derecho, síndrome tóxico, episodios sincopales y síntomas de insuficiencia cardiaca de dos meses de evolución. El electrocardiograma mostró un bloqueo auriculoventricular de tercer grado que requirió la implantación de un marcapasos externo. El ecocardiograma demostró la presencia de una masa intracardiaca y de líquido en pericardio que tuvo que ser drenado. Fue intervenida quirúrgicamente observándose un tumor que ocupaba las dos cámaras cardiacas derechas y que infiltraba aorta, arterias pulmonares y parte del tabique interven-33 [0212-7199(2002) RESUMENFundamento: El linfoma cardiaco primario (LCP) es muy infrecuente en pacientes sin alteraciones inmunitarias habiéndose descrito unos 50 casos en el mundo hasta 1996. Su patogenia no se conoce y algunos estudios que han investigado la presencia del virus de Epstein Barr en el tumor en general no lo han demostrado.Casos: Se describen los casos de dos pacientes con LCP. En ambos casos el diagnóstico fue realizado post mortem.Ambos pacientes presentaban un linfoma B de células grandes difuso. En los dos casos se ha identificado la presencia de focos inflamatorios a cierta distancia del tumor. No se ha podido demostrar la presencia de VEB en el tumor.Conclusiones: Los LCPs son tumores de rápido crecimiento con un pronóstico muy desfavorable. El virus de Epstein-Barr no parece desempeñar un papel en la etiopatogenia de estos tumores.

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Cardiac Lymphoma Associated with Superior Vena Caval Syndrome and Cardiac Tamponade: Case History

Cited by 18 publications

References 7 publications

Non-Hodgkin's Malignant Lymphoma of the Bone with Intracavitary Cardiac Involvement.

Non-Hodgkin's Malignant Lymphoma of the Bone with Intracavitary Cardiac Involvement.

Primary cardiac lymphoma in immunocompetent patients: a report of three cases and review of the literature

Linfoma cardiaco primario: Presentación de dos casos en pacientes inmunocompetentes

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