“…Effort is continuing to grow to obtain valuable information and better understanding, with less invasive approaches including magnetic resonance imaging (MRI), mathematical modeling, and computational fluid dynamics. [8][9][10] In an article by Fang et al in the February 2018 Journal edition, "Validation of a Mathematical Model of a Bidirectional Glenn Circulation with Aortopulmonary Collaterals and the Implications for Qp/Qs Calculation," the authors develop a mathematical model of oxygen delivery kinetics of the BDG circulation in the presence of APC flow. 11 This article provides a framework for understanding the mechanisms of oxygenation in the unique BDG circulation and improves on previously described models by Santamore et al 12 One of the elegant features of the model presented by Fang et al is that in defining coefficients for the extent of APC flow (k), the model equations collapse when k ¼ 0 and match the previous work by Santamore.…”