Cardiac Magnetic Resonance Feature Tracking: A Novel Method to Assess Left Ventricular Three-Dimensional Strain Mechanics After Chronic Myocardial Infarction

Yang, Liping; Cao, Shaodong; Liu, Wei; Wang, Tianzuo; Xu, Hanshan; Gao, Chao; Zhang, Lingbo; Wang, Kezheng

doi:10.1016/j.acra.2020.03.013

Cited by 11 publications

(12 citation statements)

References 28 publications

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“…With changes in LV shape, alterations in function have been reported: Global longitudinal strain (GLS), global radial strain (GRS) and global circumferential strain (GCS) were found to be significantly decreased in magnitude in patients with MI when compared with controls [ 15 ]. While all three strain indices are impaired in MI patients, GLS was found to be the strongest predictor for major adverse cardiac events (MACE) [ 16 ] and most consistently detected the change in remodelled LVs during follow-up across different studies [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Cardiovascular magnetic resonance imaging of functional and microstructural changes of the heart in a longitudinal pig model of acute to chronic myocardial infarction

Stoeck

Deuster

Füetterer

et al. 2021

Journal of Cardiovascular Magnetic Resonance

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Background We examined the dynamic response of the myocardium to infarction in a longitudinal porcine study using relaxometry, functional as well as diffusion cardiovascular magnetic resonance (CMR). We sought to compare non contrast CMR methods like relaxometry and in-vivo diffusion to contrast enhanced imaging and investigate the link of microstructural and functional changes in the acute and chronically infarcted heart. Methods CMR was performed on five myocardial infarction pigs and four healthy controls. In the infarction group, measurements were obtained 2 weeks before 90 min occlusion of the left circumflex artery, 6 days after ischemia and at 5 as well as 9 weeks as chronic follow-up. The timing of measurements was replicated in the control cohort. Imaging consisted of functional cine imaging, 3D tagging, T2 mapping, native as well as gadolinium enhanced T1 mapping, cardiac diffusion tensor imaging, and late gadolinium enhancement imaging. Results Native T1, extracellular volume (ECV) and mean diffusivity (MD) were significantly elevated in the infarcted region while fractional anisotropy (FA) was significantly reduced. During the transition from acute to chronic stages, native T1 presented minor changes (< 3%). ECV as well as MD increased from acute to the chronic stages compared to baseline: ECV: 125 ± 24% (day 6) 157 ± 24% (week 5) 146 ± 60% (week 9), MD: 17 ± 7% (day 6) 33 ± 14% (week 5) 29 ± 15% (week 9) and FA was further reduced: − 31 ± 10% (day 6) − 38 ± 8% (week 5) − 36 ± 14% (week 9). T2 as marker for myocardial edema was significantly increased in the ischemic area only during the acute stage (83 ± 3 ms infarction vs. 58 ± 2 ms control p < 0.001 and 61 ± 2 ms in the remote area p < 0.001). The analysis of functional imaging revealed reduced left ventricular ejection fraction, global longitudinal strain and torsion in the infarct group. At the same time the transmural helix angle (HA) gradient was steeper in the chronic follow-up and a correlation between longitudinal strain and transmural HA gradient was detected (r = 0.59 with p < 0.05). Comparing non-gadolinium enhanced data T2 mapping showed the largest relative change between infarct and remote during the acute stage (+ 33 ± 4% day 6, with p = 0.013 T2 vs. MD, p = 0.009 T2 vs. FA and p = 0.01 T2 vs. T1) while FA exhibited the largest relative change between infarct and remote during the chronic follow-up (+ 31 ± 2% week 5, with p = N.S. FA vs. MD, p = 0.03 FA vs. T2 and p = 0.003 FA vs. T1). Overall, diffusion parameters provided a higher contrast (> 23% for MD and > 27% for FA) during follow-up compared to relaxometry (T1 17–18%/T2 10–20%). Conclusion During chronic follow-up after myocardial infarction, cardiac diffusion tensor imaging provides a higher sensitivity for mapping microstructural alterations when compared to non-contrast enhanced relaxometry with the added benefit of providing directional tensor information to assess remodelling of myocyte aggregate orientations, which cannot be otherwise assessed.

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Section: Introductionmentioning

confidence: 99%

Cardiovascular magnetic resonance imaging of functional and microstructural changes of the heart in a longitudinal pig model of acute to chronic myocardial infarction

Stoeck

Deuster

Füetterer

et al. 2021

Journal of Cardiovascular Magnetic Resonance

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“…Two-dimensional echocardiography (2DEcho) studies have demonstrated that strain may predict adverse remodeling ( 4 , 7 ). 2DEcho is a time and cost-effective standard procedure in post-MI care but is limited by the skills of the operator and problems evaluating segments due to artifacts and pulmonary shadowing ( 8 ). Cardiac magnetic resonance (CMR) is considered the reference method for the assessment of LV anatomy and function but has some drawbacks, such as being time-consuming, unsuitable for claustrophobic patients, and often requiring the use of gadolinium contrast, which is contraindicated in renal failure ( 9 – 12 ).…”

Section: Introductionmentioning

confidence: 99%

“…The techniques used in FT and fast-SENC are discussed in Amzulescu et al ( 6 ). FT is computed on cine-loops which are part of the standard balanced steady-state free precession (bSSFP) CMR examination ( 8 , 16 ). These segmented 2D cine-loops are acquired over the entire heart cycle, usually “averaged” from 5 to 10 heartbeats, which makes deformation measurement possible for each time step ( 6 , 16 , 20 ).…”

Section: Introductionmentioning

confidence: 99%

A head-to-head comparison of myocardial strain by fast-strain encoding and feature tracking imaging in acute myocardial infarction

El-Saadi

Engvall

Alfredsson

et al. 2022

Front. Cardiovasc. Med.

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BackgroundMyocardial infarction (MI) is a major cause of heart failure. Left ventricular adverse remodeling is common post-MI. Several studies have demonstrated a correlation between reduced myocardial strain and the development of adverse remodeling. Cardiac magnetic resonance (CMR) with fast-strain encoding (fast-SENC) or feature tracking (FT) enables rapid assessment of myocardial deformation. The aim of this study was to establish a head-to-head comparison of fast-SENC and FT in post-ST-elevated myocardial infarction (STEMI) patients, with clinical 2D speckle tracking echocardiography (2DEcho) as a reference.MethodsThirty patients treated with primary percutaneous coronary intervention for STEMI were investigated. All participants underwent CMR examination with late gadolinium enhancement, cine-loop steady-state free precession, and fast-SENC imaging using a 1.5T scanner as well as a 2DEcho. Global longitudinal strain (GLS), segmental longitudinal strain (SLS), global circumferential strain (GCS), and segmental circumferential strain (SCS) were assessed along with the MI scar extent.ResultsThe GCS measurements from fast-SENC and FT were nearly identical: the mean difference was 0.01 (2.5)% (95% CI – 0.92 to 0.95). For GLS, fast-SENC values were higher than FT, with a mean difference of 1.8 (1.4)% (95% CI 1.31–2.35). Tests of significance for GLS did not show any differences between the MR methods and 2DEcho. Average strain in the infarct-related artery (IRA) segments compared to the remote myocardium was significantly lower for the left anterior descending artery and right coronary artery culprits but not for the left circumflex artery culprits. Fast-SENC displayed a higher area under the curve for detecting infarcted segments than FT for both SCS and SLS.ConclusionGLS and GCS did not significantly differ between fast-SENC and FT. Both showed acceptable agreement with 2DEcho for longitudinal strain. Segments perfused by the IRA showed significantly reduced strain values compared to the remote myocardium. Fast-SENC presented a higher sensitivity and specificity for detecting infarcted segments than FT.

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“…These measurements provide objective evaluations of subclinical RV dysfunction before clinically obvious RVEF reductions. The CMR-FT method has recently been identified as a novel method of assessing the quantitative function of the biventricular myocardium [12,21]. This technology is based on tissue voxel motion-tracking technology derived from CMR cine imaging.…”

Section: Resultsmentioning

confidence: 99%

Cardiac Magnetic Resonance Imaging Feature Tracking for Quantifying Left Ventricle Deformation in Type 2 Diabetic Patients

Alshammari¹,

Almutairi²,

Alshammari³

et al. 2022

Int J Pharm Res Allied Sci

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An evaluation of myocardial function is necessary to assess the condition of a patient's heart. Although ejection fraction is used as a measure of myocardial function, many common cardiac illnesses affect the myocardium locally rather than globally. It may therefore be possible to determine the motion of the regional wall of the heart by evaluating myocardial strain. Studying the efficacy of CMR feature tracking in diabetics Type 2 To determine whether the use of MRI feature tracking is effective in detecting myocardial strain deformations in diabetics and healthy individuals. This study involved 80 patients, 40 of whom had Type 2 diabetes and 40 of whom did not, who were subjected to cardiac MRI and echocardiography. Post-processing was done offline using CMR feature tracking and echocardiography speckle tracking, followed by SPSS analysis of the data. T2DM patients and controls did not demonstrate any significant differences in the study. There was a significant decrease in the LV GLS and LV GRS values among T2DM patients (p 0.0001) as compared to normal controls. Where the LV GLS was in controls (-20±5) and diabetes (-15±2). The CMR-FT method is well suited for accommodating STE, providing additional information in clinical trials, which can be used interchangeably. This study recommends that feature tracking (FT-CMR) and speckle tracking echocardiography (STE-Echo) be incorporated into the clinical practices of hail hospitals due to their positive results in diagnosing myocardial deformation.

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Cardiac Magnetic Resonance Feature Tracking: A Novel Method to Assess Left Ventricular Three-Dimensional Strain Mechanics After Chronic Myocardial Infarction

Cited by 11 publications

References 28 publications

Cardiovascular magnetic resonance imaging of functional and microstructural changes of the heart in a longitudinal pig model of acute to chronic myocardial infarction

Cardiovascular magnetic resonance imaging of functional and microstructural changes of the heart in a longitudinal pig model of acute to chronic myocardial infarction

A head-to-head comparison of myocardial strain by fast-strain encoding and feature tracking imaging in acute myocardial infarction

Cardiac Magnetic Resonance Imaging Feature Tracking for Quantifying Left Ventricle Deformation in Type 2 Diabetic Patients

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