Cardiac magnetic resonance imaging characteristics of isolated left ventricular noncompaction in a Chinese adult Han population

Abstract

To analyze cardiac magnetic resonance imaging (CMR) characteristics in patients with isolated left ventricular noncompaction (IVNC) and assess its value in the diagnosis of IVNC in a Chinese adult Han population. We collected a consecutive series of 30 patients with IVNC from January 1, 2007, to December 31, 2008. During the same period, we prospectively included patients drawn from groups given a potential differential diagnosis for IVNC. All magnetic resonance images were analyzed using 17-segment model. Left ventricular ejection fraction was significantly lower for patients with DCM (16.2 ± 5.2%, P < 0.001) and higher in AR (47.6 ± 16.2%, P = 0.009), AS (54.6 ± 21.1%, P = 0.001) and HHD (62.4 ± 6.8%, P < 0.001) compared with IVNC (33.0 ± 14.1%). The two-layered structure was most frequently seen at the apical segments, followed by the mid-cavity and basal segments in patients with INVC. The anterior and lateral walls were more commonly involved in patients with IVNC. The number of noncompacted segments and end-diastolic ratio of non-compacted to compacted myocardium (NC/C ratio) was greater in patients with IVNC than in other five groups. The end-diastolic NC/C ratio of >2.5 had 96.4% sensitivity and 97.4% specificity for identifying patients with IVNC. CMR provides an accurate and reliable evaluation of the localization and extent of noncompacted myocardium at end-diastole. The end-diastolic NC/C ratio of >2.5 had high diagnostic accuracy for IVNC in a Chinese adult Han population.

Cardiac magnetic resonance imaging in arrhythmogenic right ventricular cardiomyopathy: correlation to the QRS dispersion

“…Each section was then acquired in a single breath hold in 8-14s with 15-25 temporal phases per heartbeat; 15-20 minutes after injection of 0.2 mmol/kg of gadolinium diethylenetriamine pentaacetic acid (Magnevist, Schering, Berlin, Germany), the images of late gadolinium enhancement (LGE) were obtained in a contiguous set of short-axis sections covering the entire ventricle, and in long-axis views to detect areas of LGE using a phase-sensitive inversion recovery spoiled gradient echo sequence (TR/TE=8.7/3.4ms, slice thickness=6 mm, imaging matrix=256×256, FOV=350 mm, flip angle=15°). The sequence mentioned above was previously reported [11,12].…”

Three-Dimensional Phase-Sensitive Inversion-Recovery Turbo FLASH Sequence for the Assessment of Left Ventricular Myocardial Scar in Swine

“…Due to the PSIR technique, a nominal value of TI =300ms was used, rather than an additional breathhold TI scout technique was performed to determine the optimal TI to suppress the normal myocardium [14,15]. The sequence mentioned above was previously reported [18,19]. …”

The Clinical and Echocardiographic Analysis of Noncompaction Cardiomyopathy in Misdiagnosis and Missed Diagnosis

“…Due to the multiple positions and sequences, high softtissue resolution and spatial resolution, CMR is being used in diagnosis of NCC gradually [29,30]. Studies show that CMR can display the pathological cardiac muscle more clearly, and is easier to detect the apex and lateral wall of left ventricle [29][30][31].…”

“…Studies show that CMR can display the pathological cardiac muscle more clearly, and is easier to detect the apex and lateral wall of left ventricle [29][30][31]. Because of highly variable LV trabeculation, qualitative or even semi-quantitative parameters to differentiate normal compaction of the myocardium in healthy subjects from NCC or from other cardiomyopathies like DCM or hypertrophic cardiomyopathy (HCM) might be difficult by using echocardiography.…”