Cardiac magnetic resonance imaging with T2 mapping for the monitoring of acute heart transplant rejection in patients with problematic endomyocardial biopsy: in anticipation of new recommendations

Dorniak, Karolina; Stopczyńska, Iwona; Heeswijk, Ruud B. van; Żaczyńska-Buchowiecka, Marta; Fijałkowska, Jadwiga; Glińska, Anna; Gruchała, Marcin; Szurowska, Edyta; Dudziak, Maria; Sabisz, Agnieszka

doi:10.33963/kp.15852

Cited by 5 publications

(3 citation statements)

References 11 publications

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“…AME was also detected in heart transplant recipients with ongoing acute rejection confirmed by biopsy [ 62 , 63 , 64 ]. The possibility of non-invasive diagnosis of rejection by CMR could potentially avoid the current need of consecutive myocardial biopsies, with non-negligible risks for patients’ safety.…”

Section: Other Cardiac Diseasesmentioning

confidence: 99%

Cardiac Magnetic Resonance—Detected Acute Myocardial Edema as Predictor of Favourable Prognosis: A Comprehensive Review

Sinigiani

Michieli

Conti

et al. 2023

JCDD

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Acute myocardial edema (AME) is increased water content in the myocardium and represents the first and transient pathophysiological response to an acute myocardial injury. In-vivo and non-invasive evaluation is feasible with cardiac magnetic resonance (CMR), which is a powerful imaging technique capable of tissue characterization. In the clinical setting, early demonstration of AME has a recognized diagnostic value for acute coronary syndromes and acute myocarditis, although its prognostic value is not well established. This article provides a comprehensive narrative review on the clinical meaning of AME in heart diseases. In particular, the available evidence of a possible favourable prognostic value in several clinical scenarios is addressed.

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Section: Other Cardiac Diseasesmentioning

confidence: 99%

Cardiac Magnetic Resonance—Detected Acute Myocardial Edema as Predictor of Favourable Prognosis: A Comprehensive Review

Sinigiani

Michieli

Conti

et al. 2023

JCDD

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“…The technique has among others been shown to aid in the diagnosis of myocarditis (35,53), where it had a high sensitivity compared to other CMR imaging techniques for the detection or exclusion of biopsy-proven myocarditis (Figure 4). T2 mapping has also been applied for the diagnosis of the area at risk after myocardial infarction (54,55), the monitoring of the effects of chemotherapy on the heart (56), and acute rejection of the transplanted heart (57,58).…”

Section: T 2 Mappingmentioning

confidence: 99%

The Road Toward Reproducibility of Parametric Mapping of the Heart: A Technical Review

Ogier

Bustin

Cochet

et al. 2022

Front. Cardiovasc. Med.

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Parametric mapping of the heart has become an essential part of many cardiovascular magnetic resonance imaging exams, and is used for tissue characterization and diagnosis in a broad range of cardiovascular diseases. These pulse sequences are used to quantify the myocardial T1, T2, T2*, and T1ρ relaxation times, which are unique surrogate indices of fibrosis, edema and iron deposition that can be used to monitor a disease over time or to compare patients to one another. Parametric mapping is now well-accepted in the clinical setting, but its wider dissemination is hindered by limited inter-center reproducibility and relatively long acquisition times. Recently, several new parametric mapping techniques have appeared that address both of these problems, but substantial hurdles remain for widespread clinical adoption. This review serves both as a primer for newcomers to the field of parametric mapping and as a technical update for those already well at home in it. It aims to establish what is currently needed to improve the reproducibility of parametric mapping of the heart. To this end, we first give an overview of the metrics by which a mapping technique can be assessed, such as bias and variability, as well as the basic physics behind the relaxation times themselves and what their relevance is in the prospect of myocardial tissue characterization. This is followed by a summary of routine mapping techniques and their variations. The problems in reproducibility and the sources of bias and variability of these techniques are reviewed. Subsequently, novel fast, whole-heart, and multi-parametric techniques and their merits are treated in the light of their reproducibility. This includes state of the art segmentation techniques applied to parametric maps, and how artificial intelligence is being harnessed to solve this long-standing conundrum. We finish up by sketching an outlook on the road toward inter-center reproducibility, and what to expect in the future.

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“…Several studies have reported that cardiac magnetic resonance (CMR) could detect CAR [3,4]. A novel imaging method -dynamic computed tomography perfusion (CTP) -has specificity and sensitivity comparable to CMR.…”

mentioning

confidence: 99%

Dynamic computed tomography perfusion imaging for detection of cardiac allograft rejection and myocardial ischemia in a heart transplant recipient

et al. 2022

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Cardiac magnetic resonance imaging with T2 mapping for the monitoring of acute heart transplant rejection in patients with problematic endomyocardial biopsy: in anticipation of new recommendations

Cited by 5 publications

References 11 publications

Cardiac Magnetic Resonance—Detected Acute Myocardial Edema as Predictor of Favourable Prognosis: A Comprehensive Review

Cardiac Magnetic Resonance—Detected Acute Myocardial Edema as Predictor of Favourable Prognosis: A Comprehensive Review

The Road Toward Reproducibility of Parametric Mapping of the Heart: A Technical Review

Dynamic computed tomography perfusion imaging for detection of cardiac allograft rejection and myocardial ischemia in a heart transplant recipient

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