This article is the latest in the series of literature reviews that have appeared in the Journal. We have attempted to highlight important recent literature and new trends in single-photon emission computerized tomography (SPECT) myocardial perfusion imaging, cardiac positron emission tomography (PET), cardiac computerized tomography (CT), and cardiac magnetic resonance imaging (MRI). With rare exceptions, these articles were published between January 1, 2003, and May 31, 2004, in the English-language literature. Space considerations have forced us to quite arbitrarily include some articles and exclude others. We apologize in advance to those whose work we may have inadvertently overlooked or consciously excluded. Many of the articles that we have not described were very well done and published in prominent journals. In many cases, we felt that they were confirmations of previous literature on the same subject and, therefore, of lesser interest to the readership. Time and the advance of science are likely to prove us wrong in several cases.We have chosen to organize the literature around topical themes rather than imaging modalities in an attempt to encourage you to think broadly rather than simply within a "silo" of the imaging modality of particular interest to you.
TECHNICAL ADVANCESSPECT myocardial perfusion imaging. Although SPECT myocardial perfusion imaging is a very mature modality, important reports describing and evaluating technical advances continue to appear. Narayanan et al. reported a very rigorous receiver-operating characteristic analysis of the effects of ordered-subset expectation maximization with attenuation correction (AC), scatter correction (SC), and resolution compensation (RC) on 100 patients using seven different observers (1). The combination of AC ϩ SC ϩ RC provided a greater area under the receiver-operating characteristic curve for the overall detection of coronary artery disease (CAD), as well as for perfusion defects in the left anterior descending and left circumflex territories.Manrique et al.(2) reported that photon energy recovery for scatter correction improved the accuracy of left ventricular (LV) volume measurement in phantoms, and increased image contrast and LV volume in patients. Grossman et al. (3) reported that a gender-independent normal database for attenuation-correction studies significantly improved specificity and normalcy rate without a significant loss of sensitivity.Svensson et al. (4) reported less positive results from the application of three widely utilized software packages for quantitation to 50 consecutive patients. The summed difference score classification derived from the software packages disagreed in nearly half of the patients and disagreed markedly in 12%. Cardiac PET. Several studies reported on the use of gated fluorine-18 fluorodeoxyglucose (FDG) cardiac PET imaging. Croteau et al. (5) performed list-mode PET studies and echocardiography in rats. Agreement between PET and echo for volumes (R 2 ϭ 0.49 for diseased rats) and for ejection fractio...