Cardiac magnetic resonance, transthoracic and transoesophageal echocardiography: a comparison of in vivo assessment of ventricular function in rats

Richardson, J. David; Bertaso, A.; Frost, L.; Psaltis, Peter J.; Carbone, A.; Koschade, B.; Wong, D.; Nelson, Adam; Paton, Sharon; Williams, K.; Worthley, M.; Teo, K.; Gronthos, Stan; Zannettino, Andrew C.W.; Worthley, Stephen G.

doi:10.1177/0023677213494373

Cited by 7 publications

(2 citation statements)

References 21 publications

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“…Two-dimensional echocardiography is a well-established tool that has have been largely used for the assessment of cardiac function and structure using techniques and indices familiar from human echocardiography. It offers a rapid and low cost evaluation of heart anatomy, function and biomechanics (Richardson et al, 2013 ) and response to treatment (Bao et al, 2013 ; Matthews et al, 2013 ). But, its results depend on the body complexion, echographic window and the HR of the scanned animal.…”

Section: Imaging In Myocardial Infarction and Coronary Artery Diseasementioning

confidence: 99%

Cardiovascular imaging: what have we learned from animal models?

et al. 2015

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Cardiovascular imaging has become an indispensable tool for patient diagnosis and follow up. Probably the wide clinical applications of imaging are due to the possibility of a detailed and high quality description and quantification of cardiovascular system structure and function. Also phenomena that involve complex physiological mechanisms and biochemical pathways, such as inflammation and ischemia, can be visualized in a non-destructive way. The widespread use and evolution of imaging would not have been possible without animal studies. Animal models have allowed for instance, (i) the technical development of different imaging tools, (ii) to test hypothesis generated from human studies and finally, (iii) to evaluate the translational relevance assessment of in vitro and ex-vivo results. In this review, we will critically describe the contribution of animal models to the use of biomedical imaging in cardiovascular medicine. We will discuss the characteristics of the most frequent models used in/for imaging studies. We will cover the major findings of animal studies focused in the cardiovascular use of the repeatedly used imaging techniques in clinical practice and experimental studies. We will also describe the physiological findings and/or learning processes for imaging applications coming from models of the most common cardiovascular diseases. In these diseases, imaging research using animals has allowed the study of aspects such as: ventricular size, shape, global function, and wall thickening, local myocardial function, myocardial perfusion, metabolism and energetic assessment, infarct quantification, vascular lesion characterization, myocardial fiber structure, and myocardial calcium uptake. Finally we will discuss the limitations and future of imaging research with animal models.

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Section: Imaging In Myocardial Infarction and Coronary Artery Diseasementioning

confidence: 99%

Cardiovascular imaging: what have we learned from animal models?

et al. 2015

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“…Validation studies have been performed on humans but the results cannot be generalized to rodents. Thorough rodent study validations are unfortunately limited to left ventricular function in 1.5-7 T scanners (Nahrendorf et al 2003, Arias et al 2013, Richardson et al 2013. Previous RV studies have only evaluated one particular non-invasive method versus right heart catheterization (Jones et al 2002, Kato et al 2003, Koskenvuo et al 2010 or used modalities beyond general availability (Urboniene et al 2010).…”

Section: Introductionmentioning

confidence: 99%

Limitations and pitfalls in measurements of right ventricular stroke volume in an animal model of right heart failure

Vildbrad

Andersen

et al. 2015

Physiol. Meas.

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Right heart failure occurs in various heart and pulmonary vascular diseases and may be fatal. We aimed to identify limitations in non-invasive measurements of right ventricular stroke volume in an animal model of right ventricular failure. Data from previous studies randomising rats to pulmonary trunk banding (PTB, n = 33) causing pressure-overload right ventricular failure or sham operation (n = 16) was evaluated retrospectively. We measured right ventricular stroke volume by high frequency echocardiography and magnetic resonance imaging (MRI). We found correlation between right ventricular stroke volume measured by echocardiography and MRI in the sham animals (r = 0.677, p = 0.004) but not in the PTB group. Echocardiography overestimated the stroke volume compared to MRI in both groups. Intra- and inter-observer variation did not explain the difference. Technical, physiological and anatomical issues in the pulmonary artery might explain why echocardiography over-estimates stroke volume. Flow acceleration close to the pulmonary artery banding can cause uncertainties in the PTB model and might explain the lack of correlation. In conclusion, we found a correlation in right ventricular stroke volume measured by echocardiography versus MRI in the sham group but not the PTB group. Echocardiography overestimated right ventricular stroke volume compared to MRI.

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Assessment of the early stage of cardiac remodeling of spontaneously hypertensive heart failure rats using the quantitative 3-dimensional analysis provided by acipimox-enhanced FDG-PET

Maskali¹,

Poussier

Louis

et al. 2014

Int J Cardiovasc Imaging

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Spontaneously hypertensive heart failure rats (SHHF) appear to constitute an original model for analyzing the evolution of the metabolic syndrome towards heart failure. This study aimed to characterize early cardiac dysfunction and remodeling in SHHF rats: (1) as compared with spontaneously hypertensive rats (SHR) and with a control group of Kyoto rats (WKY), and (2) by using the 3-dimensional quantitative analysis provided by acipimox-enhanced positron emission tomography (PET) with (18)F-fluorodesoxyglucose (FDG). Left ventricular (LV) ejection fraction (EF) and volume were quantified by automatic software on the FDG-PET images recorded in SHR (n = 20), SHHF (n = 18) and WKY-rats (n = 19) at ages 3 or 10 months old. Arterial blood pressure was determined by cardiac catheterization and cardiac fibrosis was quantified after sacrifice. Blood pressure was similarly elevated in SHR and SHHF rats (respective systolic blood pressures at 10-months: 199 ± 39 vs. 205 ± 2 mmHg), but SHHF rats had higher body mass than SHR rats (at 10-months, 630 ± 36 vs. 413 ± 27 g, p < 0.05) and higher blood levels of cholesterol and of triglycerides. At 3 months, cardiac parameters did not show significant differences between groups but at 10-months, SHHF and SHR rats exhibited an enhancement in myocardial mass and fibrosis associated with a clear decline in LV-EF (SHHF: 46 ± 6 %; SHR: 47 ± 5 %) as compared with WKY (56 ± 6 %, p < 0.01 for both comparisons). Cardiac remodeling of SHHF rats was clearly observable by FDG-PET from the age of 10-months, but in a similar way to that observed for SHR rats, suggesting a predominant role of hypertension.

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Cardiac magnetic resonance, transthoracic and transoesophageal echocardiography: a comparison of in vivo assessment of ventricular function in rats

Cited by 7 publications

References 21 publications

Cardiovascular imaging: what have we learned from animal models?

Cardiovascular imaging: what have we learned from animal models?

Limitations and pitfalls in measurements of right ventricular stroke volume in an animal model of right heart failure

Assessment of the early stage of cardiac remodeling of spontaneously hypertensive heart failure rats using the quantitative 3-dimensional analysis provided by acipimox-enhanced FDG-PET

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