Cardiac Manifestation involvement in Dengue Infection

Girdhar, Dr Rajiv

doi:10.18535/jmscr/v5i11.102

Cited by 2 publications

(1 citation statement)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This phenomenon, although not well understood, is related to inflammatory factors, with the release of cytokines (TNF-α, interleukins 6, 13, and 18, and cytotoxic factor), greater susceptibility to viral infections with possible tissue infiltration, host genetic factors, and viral load [30,67,81,83]. Despite this, ventricular dysfunction associated with myocarditis and electrocardiographic changes are, in most cases, transient [55,62]. Therefore, it is clear that myocarditis is one of the most important complications in patients with dengue, especially in children and young adults.…”

Section: Discussionmentioning

confidence: 99%

Heart Disease and Arboviruses: A Systematic Review and Meta-Analysis

Nicacio

Gomes

Carmo

et al. 2022

Viruses

View full text Add to dashboard Cite

Dengue fever, chikungunya, and zika are highly prevalent arboviruses transmitted by hematophagous arthropods, with a widely neglected impact in developing countries. These diseases cause acute illness in diverse populations, as well as potential cardiovascular complications. A systematic review was carried out to investigate the burden of cardiac involvement related to these arboviruses. Multiple databases were searched for articles that investigated the association of cardiovascular diseases with arboviruses, published up to March 2022. Relevant articles were selected and rated by two independent reviewers. Proportion meta-analysis was applied to assess the frequency-weighted mean of the cardiovascular findings. A total of 42 articles were selected (n = 76,678 individuals), with 17 manuscripts on dengue and 6 manuscripts on chikungunya undergoing meta-analysis. The global pooled incidence of cardiac events in dengue fever using a meta-analysis was 27.21% (95% CI 20.21–34.83; I2 = 94%). The higher incidence of dengue-related myocarditis was found in the population younger than 20 years old (33.85%; 95% CI 0.00–89.20; I2 = 99%). Considering the studies on chikungunya (n = 372), the global pooled incidence of cardiac involvement using a meta-analysis was 32.81% (95% CI 09.58–61.49, I2 = 96%). Two Zika studies were included that examined cases of infection by vertical transmission in Brazil, finding everything from structural changes to changes in heart rate variability that increase the risk of sudden death. In conclusion, cardiac involvement in arboviruses is not uncommon, especially in dengue fever.

show abstract