Cardiac Manifestations on Anti-Phospholipid Syndrome

Ah, Faisal

doi:10.29328/journal.jcn.1001002

J Clini Nephrol 2017

DOI: 10.29328/journal.jcn.1001002

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Cardiac Manifestations on Anti-Phospholipid Syndrome

Faisal Ah¹

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2018

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An extraordinary case of recurrent stroke, disseminated thrombosis and endocarditis

Thomas¹,

Shaikh

Pradeep

2018

BMJ Case Reports

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A 43-year-old woman with no known cardiovascular risk factors was admitted with a second episode of ischaemic stroke. She was not a known case of connective tissue disease like systemic lupus erythematosus or antiphospholipid syndrome (APS). During the current episode, she was found to have markedly deranged coagulation parameters and laboratory evidence of microangiopathic haemolysis, but no evidence of sepsis or active bleeding. Further investigation revealed multiple organ infarcts. A diagnosis of probable catastrophic APS was made and she improved dramatically with a combination of plasmapheresis, corticosteroids and therapeutic anticoagulation. Serological markers of APS were negative. Her hospital course was complicated by Libman Sacks endocarditis with significant aortic regurgitation that improved markedly with anticoagulation obviating the need for high-risk cardiac surgery. At discharge, she was stable and well and was advised long-term anticoagulation and rheumatology follow-up.

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An extraordinary case of recurrent stroke, disseminated thrombosis and endocarditis

Thomas¹,

Shaikh

Pradeep

2018

BMJ Case Reports

View full text Add to dashboard Cite

show abstract

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Cardiac Manifestations on Anti-Phospholipid Syndrome

Cited by 1 publication

References 14 publications

An extraordinary case of recurrent stroke, disseminated thrombosis and endocarditis

An extraordinary case of recurrent stroke, disseminated thrombosis and endocarditis

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