Cardiac markers and their point-of-care testing for diagnosis of acute myocardial infarction

Yang, Zhen; Zhou, Dao Min

doi:10.1016/j.clinbiochem.2006.05.011

Cited by 122 publications

(67 citation statements)

References 105 publications

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“…Ранняя диагностика сердечно-сосудистых заболеваний, занимающих первое место среди всех случаев смерти, является одним из основных факторов их успешного лечения. Открытие новых биохимических маркеров острого инфаркта миокарда (ОИМ) определило потребность в разработке точных экспрессных методов их определения, в результате чего были предложены новые биохимические лабораторные диагностики ОИМ [1][2][3].…”

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Electrochemical immunoanalysis of cardiac myoglobin

et al. 2010

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Method targeting the direct monitoring of myoglobin based on analysis of electrochemical parameters of modified electrodes were proposed. Method of direct detection is based on interaction of myoglobin with anti-myoglobin with subsequent electrochemical registration of hemeprotien. Myocardial infarction biomarker myoglobin was quantified at biological level using screen printed electrodes modified with gold nanoparticles stabilized with didodecyldimethylammonium bromide (DDAB) and antibodies. Proposed method did not require signal enhancement and amplification and also labeled secondary antibodies. Electro analysis has high specificity and sensitivity. Myoglobin -antibodies interaction was studied also with electrochemical impedance spectroscopy. Sensor has low detection limit and broad diapason of working concentrations (17.8 ng/ml - 1780 ng/ml; 1 nM - 10 nM). Method based on gold nanoparticles detection on the surface of electrodes was treated for myoglobin identification. AuNP worked as an electrochemical sensing platform: the oxidation of gold surface (resulted in gold oxide formation) upon polarization served as a basis for analytical response. The difference of cathodic peak area and peak high of gold oxide reduction in the case of electrodes with antibodies and electrodes with antibodies - myoglobin complex, was registered.

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Electrochemical immunoanalysis of cardiac myoglobin

et al. 2010

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“…This interruption leads to apoptosis of cardiac cells, which release into the extracellular environment a variety of intracellular constituents such as organelles, cytosolic enzymes and biologically active structural proteins that are subsequently considered biomarkers for diagnosis and / or prognosis of injury [1]. In the majority of cases, AMI leads to severe heart failure and is therefore considered one of the leading causes of morbidity and mortality worldwide.…”

Section: Introductionmentioning

confidence: 99%

“…In the majority of cases, AMI leads to severe heart failure and is therefore considered one of the leading causes of morbidity and mortality worldwide. A large part of the population is susceptible due to a range of risk factors such as advanced age, Diabetes mellitus, hypertension, renal insufficiency, hemodynamic instability, compromised left ventricular systolic function and the presence of atheroma plaques in large arteries that can consequently lead to atherosclerosis [1,2].…”

Section: Introductionmentioning

confidence: 99%

“…The strategies of detection of acute and chronic myocardial infarction with the advent of the discovery of new markers are usually composed of electrocardiographic examination, cTnI and cTnT cardiac troponins, as well as other markers such as myoglobin, creatine kinase (CK), MB Creatine kinase (CK-MB), and more recently ischemiamodified albumin (IMA), which is a prognostic marker of cardiac lesions [1,4,5].…”

Section: Introductionmentioning

confidence: 99%

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The Recent Advances in the Serological Detection of Acute Myocardial Infarction

Gh¹,

Ac²

2016

Clin Med Biochemistry

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Acute Myocardial Infarction (AMI) is one of the leading causes of morbidity and mortality worldwide. The greatest risk of fatality occurs within the first hours of initiation of AMI. Thus, the early diagnosis of cardiac ischemia is fundamental for the effective management of AMI patients. Inadequate diagnosis of patients with chest pain often leads to inadequate admission of patients without AMI and vice versa. In addition to the clinical history, physical examination, accurate electrocardiogram findings, and evaluation of cardiac biomarkers play an important role in the early diagnosis of acute ischemia. The present review discusses in detail the various cardiac biomarkers released during the event of an AMI.

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“…POC devices utilize rapid, diagnostic immunoassays that are able to deliver rapid TAT results in under 30 min, and require minimal sample handling and preparation. They employ systems that waive the necessity for skilled laboratory personnel to operate the assay, and have the potential to reduce length of ED patient stays and overall hospital costs [3,9]. The POC industry has increased considerably in depth as biotech companies worldwide compete to develop cTn assays that demonstrate high analytical quality with short TAT [10].…”

Section: Introductionmentioning

confidence: 99%

Cardiac troponin assays: a review of quantitative point-of-care devices and their efficacy in the diagnosis of myocardial infarction

Amundson¹,

Apple

2015

Clinical Chemistry and Laboratory Medicine (CCLM)

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Cardiac troponin (cTn) I and T are released from myocardial cells following necrosis, i.e., cell death. An accurate measure of cTn concentrations in a patient's blood following ischemia/chest pain can enable providers to determine whether or not a myocardial infarction (MI) has occurred. Point-of-care (POC) devices that measure blood cTn concentrations in under 30 min may help to significantly reduce hospital costs by managing and triaging patients out of the emergency department as quickly as possible. The use of POC devices that measure cTnI and cTnT with a coefficient of variation (CV) ≤ 20% at the 99th percentile upper reference limit (URL) limits both false positive and negative results and provides clinically acceptable findings to assist in appropriate diagnoses. This article reviews nine POC devices that measure cTn in terms of their clinical sensitivity and specificity, analytical imprecision, sample type and preparation, and each assay's principle of analysis.

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Cardiac markers and their point-of-care testing for diagnosis of acute myocardial infarction

Cited by 122 publications

References 105 publications

Electrochemical immunoanalysis of cardiac myoglobin

Electrochemical immunoanalysis of cardiac myoglobin

The Recent Advances in the Serological Detection of Acute Myocardial Infarction

Cardiac troponin assays: a review of quantitative point-of-care devices and their efficacy in the diagnosis of myocardial infarction

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