Cardiac markers: Role in the pathogenesis of arterial hypertension

Afzal, Shaheed; Rafaqat, Sana; Khurshid, Huma; Rafaqat, Simon

doi:10.5494/wjh.v10.i1.1

Cited by 7 publications

(8 citation statements)

References 77 publications

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“…The most common adverse events included chemotherapy-induced nausea, fatigue, and hematological abnormalities, as well as immunotherapy-related skin reactions and mild flu-like symptoms. Notably, these adverse events were generally manageable and less severe compared to those reported in patients undergoing more traditional chemotherapy regimens, such as platinum-based treatments, which often result in more significant hematological toxicities and gastrointestinal disturbances [34][35]. The safety profile of IPCGOR combined with IL-2, therefore, appears comparatively favorable, particularly when considering the enhanced quality of life and reduced hospitalization duration it offers.…”

Section: Discussionmentioning

confidence: 99%

Efficacy and Safety Assessment of Intrathoracic Perfusion Chemotherapy Combined with immunological factor Interleukin-2 in the Treatment of Advanced Non-Small Cell Lung Cancer: A Retrospective Cohort Study

Cao,

Zhu,

et al. 2024

J. Cancer

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Objective: This study evaluated the efficacy and safety of the gemcitabine and oxaliplatin intrathoracic perfusion chemotherapy (IPCGOR) regimen combined with interleukin-2 (IL-2) for advanced non-small cell lung cancer (NSCLC). Methods: We conducted a retrospective analysis of 460 advanced NSCLC patients from the Yunnan Province Early Cancer Diagnosis and Treatment Project (June 2020-October 2022), assessing the IPCGOR and IL-2 combination. Outcomes were measured based on RECIST 1.1 criteria, focusing on objective response rate (ORR), disease control rate (DCR), median progression-free survival (mPFS), median overall survival (MOS), and treatment safety. Results: The treatment demonstrated an ORR of 67.4%, a DCR of 97.4%, an mPFS of 8.5 months, and an MOS of 12.5 months. 14 patients underwent successful surgery post-treatment. Common adverse reactions were manageable, with no treatment-related deaths reported. Conclusion:The IPCGOR combined with IL-2 regimen shows promising efficacy and a tolerable safety profile for advanced NSCLC. These findings suggest its potential as a reference for treating advanced NSCLC. However, the study's retrospective nature and single-center design pose limitations. Future research should focus on prospective studies, randomized controlled trials, and long-term outcome assessments, particularly in diverse patient subgroups, to further validate and refine the clinical application of this regimen.

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Section: Discussionmentioning

confidence: 99%

Efficacy and Safety Assessment of Intrathoracic Perfusion Chemotherapy Combined with immunological factor Interleukin-2 in the Treatment of Advanced Non-Small Cell Lung Cancer: A Retrospective Cohort Study

Cao,

Zhu,

et al. 2024

J. Cancer

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“…This result suggests that ALT may independently contribute to the development of hypertension. Although the precise mechanism behind this association remains unclear, some researchers suggest that ALT may cause oxidative stress, faster heart rate, increased arterial stiffness, and inflammation, which can damage blood vessels and lead to the development of hypertension 23,27–30 . Previous studies have shown that elevated GGT levels are a risk factor for high blood pressure.…”

Section: Discussionmentioning

confidence: 99%

“…Although the precise mechanism behind this association remains unclear, some researchers suggest that ALT may cause oxidative stress, faster heart rate, increased arterial stiffness, and inflammation, which can damage blood vessels and lead to the development of hypertension. 23 , 27 , 28 , 29 , 30 Previous studies have shown that elevated GGT levels are a risk factor for high blood pressure. In their study, Stranges et al reported that GGT was a strong predictor of hypertension incidence over a 6‐year follow‐up period in a dose‐response relationship.…”

Section: Discussionmentioning

confidence: 99%

Investigating the relationship between liver enzymes and incidence of hypertension: A population‐based cohort study in Kharameh, a city in the South of Iran

Baeradeh,

Seif,

Rezaianzadeh

et al. 2023

Health Science Reports

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Background and AimsHypertension and abnormal liver enzymes are common health issues that frequently coexist, and recent research has suggested a possible association between them, warranting further investigation. Therefore, the aim of this study is to explore the relationship between liver enzymes and hypertension.MethodsThis prospective cohort study utilized data from the Kharameh cohort study, which is a branch of the Prospective Epidemiological Studies in Iran (PERSIAN) database. The study included 7710 participants aged between 40 and 70 years. Hypertension was defined in accordance with the European guidelines for hypertension management, and the association between liver enzymes and hypertension was modeled and predicted using Firth logistic regression.ResultsThis study investigated the association between liver enzymes and hypertension risk in a cohort of 7710 individuals aged 40–70 years. The results showed that higher levels of alanine aminotransferase (ALT), gamma glutamyl transferase (GGT), and alkaline phosphatase (ALP) were associated with an increased risk of hypertension, and this relationship remained significant even after adjusting for potential confounding factors. Additionally, separate analyses within age subgroups revealed a significant association between ALP concentration and high blood pressure in certain age ranges.ConclusionThe study demonstrated a significant association between high levels of ALT, GGT, and ALP and an increased risk of hypertension, regardless of other risk factors. These results suggest that monitoring liver enzymes, specifically ALT, GGT, and ALP, could serve as a useful tool to predict hypertension risk and identify individuals who could benefit from early intervention. Overall, these findings underscore the importance of monitoring liver function in preventing and managing hypertension.

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“…Individu yang mengalami overweight dan obesitas memiliki lebih banyak jaringan adiposa sehingga terdapat kelebihan sekresi senyawa-senyawa adipokin proinflamasi dan vasoaktif seperti angiotensin II, angiotensinogen, aldosteron, dan diiringi dengan peningkatan aktivitas renin. Hal tersebut memicu terjadinya peningkatan tekanan darah hingga ke kondisi hipertensi (19,20).…”

Section: Hubungan Status Gizi Dan Komposisi Tubuh Dengan Tekanan Darahunclassified

Hubungan status gizi, komposisi tubuh, asupan kafein dengan tekanan darah usia dewasa di Jakarta Pusat

Purwaningtyas,

Septiany,

Aini

2023

ilgi

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Latar Belakang: Prevalensi hipertensi dewasa di Indonesia mengalami peningkatan. Hipertensi pada dewasa usia ≥18 tahun mengalami peningkatan dari 25,8% menjadi 34,51%. Gaya hidup yang buruk sangat memengaruhi status gizi, komposisi tubuh, dan pola makan terutama asupan kafein yang merupakan faktor risiko hipertensi. Tujuan: untuk mengetahui hubungan status gizi, komposisi tubuh, dan asupan kafein terhadap kejadian hipertensi usia dewasa di Kelurahan Kampung Rawa, Jakarta Pusat. Metode: Penelitian ini merupakan penelitian kuantitatif dengan desain cross-sectional. Responden penelitian adalah dewasa berusia 20−55 tahun, bertempat tinggal di Kelurahan Kampung Rawa, Jakarta Pusat sebanyak 90 responden. Pengambilan sampel dilakukan dengan cluster random sampling. Analisis data dilakukan dengan uji statistic univariat, bivariat dengan menggunakan uji Chi-Square, dan multivariat menggunakan uji regresi logistik. Instumen yang digunakan berupa kuesioner, timbangan digital, microtoise, pita meter, Sphygmomanometer, Body Impedance Analyzer, dan formulir SQ-FFQ. Hasil: Indeks massa tubuh (p=0,032), lingkar pinggang (p=0,034), persen lemak (p=0,003), persen bebas lemak (p=0,023), lemak viseral (p=0,035), dan asupan kafein (p=0,003) memiliki hubungan signifikan dengan kejadian hipertensi pada usia dewasa. Kesimpulan: Status gizi, komposisi tubuh, dan asupan kafein dalam batas normal dapat mencegah terjadinya hipertensi dewasa.

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Cardiac markers: Role in the pathogenesis of arterial hypertension

Cited by 7 publications

References 77 publications

Efficacy and Safety Assessment of Intrathoracic Perfusion Chemotherapy Combined with immunological factor Interleukin-2 in the Treatment of Advanced Non-Small Cell Lung Cancer: A Retrospective Cohort Study

Efficacy and Safety Assessment of Intrathoracic Perfusion Chemotherapy Combined with immunological factor Interleukin-2 in the Treatment of Advanced Non-Small Cell Lung Cancer: A Retrospective Cohort Study

Investigating the relationship between liver enzymes and incidence of hypertension: A population‐based cohort study in Kharameh, a city in the South of Iran

Hubungan status gizi, komposisi tubuh, asupan kafein dengan tekanan darah usia dewasa di Jakarta Pusat

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