Cardiac mechanostructure: Using mechanics and anisotropy as inspiration for developing epicardial therapies in treating myocardial infarction

Dwyer, Kiera D.; Coulombe, Kareen L K

doi:10.1016/j.bioactmat.2020.12.015

Cited by 33 publications

(41 citation statements)

References 258 publications

(235 reference statements)

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“…147 The fibrous tissue formed after MI acts as a physical barrier and prevents electrical coupling of scaffolds with the heart muscle which can potentially lead to the prevention of arrhythmia and cardiac dysfunction. 148…”

Section: Characteristics Of Scaffolds For Myocardial Repairmentioning

confidence: 99%

Tunable biomaterials for myocardial tissue regeneration: promising new strategies for advanced biointerface control and improved therapeutic outcomes

Goonoo

2022

Biomater. Sci.

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Section: Characteristics Of Scaffolds For Myocardial Repairmentioning

confidence: 99%

Tunable biomaterials for myocardial tissue regeneration: promising new strategies for advanced biointerface control and improved therapeutic outcomes

Goonoo

2022

Biomater. Sci.

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“…They also exhibit negative Poisson's ratios to support CM, fibroblast, vascular smooth muscle, endothelial, and immune cells. [44] This complicated 3D geometry enables physical, chemical, and mechanical interactions among cells and ECM. [42,45,46] The specific microenvironment functions as reservoirs/delivery vehicles for growth factors (GFs) and provides cell/tissue response bioactive cues.…”

Section: Architecture-level Propertiesmentioning

confidence: 99%

Integrated Perspective of Scaffold Designing and Multiscale Mechanics in Cardiac Bioengineering

Lou

Lopez

Nautiyal

et al. 2021

Advanced NanoBiomed Research

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According to a World Health Organization (WHO) report in 2017, [1] cardiovascular diseases (CVDs) are the foremost cause of mortality, with 85% attributed to stroke and heart attack (or myocardial infarction [MI]) worldwide. The 2019 American Heart Association report [2] indicates that CVD is the leading lethal disease in the U.S., with 840 768 deaths in 2016. There is one new MI case in the U.S. every 40 s, contributing to about $351 billion in costs in 2014À2015. [2] MI gradually develops and deteriorates into inflammation, apoptosis, and inelastic fibrous scar, eventually leading to congestive heart failure (CHF). [3] Due to cardiomyocytes' (CMs) limited regeneration and proliferation ability, the effective long-term MI and CHF treatment is transplantation. There were over 3500 candidates on the heart transplant waiting list by the end of 2020, according to the national data [4] from the USA. Department of Health and Human Services. Shortage of organ donation sources, organ storage and maintenance, and post-transplantation immunologic rejection are tricky issues that are difficult to solve. Reconstruction of cardiac tissue using 3D scaffold or scaffold-free techniques has emerged as a promising alternative treatment approach.Cardiac bioengineering aims to investigate or rebuild illfunctioning myocardium tissues via CMs, scaffold-free cell sheet substrates, and implantable cell-seeded scaffolds. [3] Scaffold-free approaches include miRNA clusters, [5] spheroid models, [6] scaffold-free multiple-component cell cultures, [3,7] injectable hydrogels, [8] and organ on a chip. [9] These strategies permit direct delivery of cells or cell composites to infarcted myocardium and enable thick 3D tissue patch implantation with enhanced cell engraftment capacity. Some scaffold-free approaches can also be exploited in in vitro pathological cardiac models or ex vivo platforms for new therapy efficacy and cardiotoxicity evaluation. [6,7,9] Unlike scaffold-free pathways, cardiac scaffolds provide mechanical support to the myocardium, establish contractility/pumping, and lessen myocardial dilation and myocardial wall stress. [3] Meanwhile, significant progress has been made in stem cellderived CM tissue preparation; [10][11][12] scaffold and extracellular matrix (ECM) construction; [13][14][15][16][17] scaffold-free in situ injectable pathway development; [5][6][7]9] cell seeding, proliferation, and viabil-

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“…Tissue engineering exerts heart therapeutic effects by creating engineered biocompatible cardiac patches as a carrier to transplant heart tissue and even deliver agents in a direct and controlled manner (Bolonduro et al, 2020). Cardiac patches are often fabricated with biomaterials alone or with established cells, sometimes attached with small stimulating molecules (Dwyer & Coulombe, 2021; Feric & Radisic, 2016; Scuderi & Butcher, 2017). The inspiration of epicardial therapy for MIs possibly derives from cardiac mechanical structure, including mechanics and anisotropy (Dwyer & Coulombe, 2021).…”

Section: Introductionmentioning

confidence: 99%

“…Cardiac patches are often fabricated with biomaterials alone or with established cells, sometimes attached with small stimulating molecules (Dwyer & Coulombe, 2021; Feric & Radisic, 2016; Scuderi & Butcher, 2017). The inspiration of epicardial therapy for MIs possibly derives from cardiac mechanical structure, including mechanics and anisotropy (Dwyer & Coulombe, 2021). These features emphasize the remarkable role of patches incorporated with electrically conductive materials to allow for coupled electromechanics and coordinated contraction.…”

Section: Introductionmentioning

confidence: 99%

Bioelectricity‐coupling patches for repairing impaired myocardium

Qiu

2022

WIREs Nanomed Nanobiotechnol

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Cardiac abnormalities, which account for extensive burdens on public health and economy, drive necessary attempts to revolutionize the traditional therapeutic system. Advances in cardiac tissue engineering have expanded a highly efficacious platform to address cardiovascular events, especially cardiac infarction. Current efforts to overcome biocompatible limitations highlight the constructs of a conductive cardiac patch to accelerate the industrial and clinical landscape that is amenable for patient-accurate therapy, regenerative medicine, disease modeling, and drug delivery. With the notion that cardiac tissue synchronically contracts triggered by electrical pulses, the cardiac patches based on conductive materials are developed and treated on the dysfunctional heart. In this review, we systematically summarize distinct conductive materials serving as the most promising alternatives (conductive nanomaterials, conductive polymers, piezoelectric polymers, and ionic electrolytes) to achieve electric signal transmission and engineered cardiac tissues. Existing applications are discussed considering how these patches containing conductive candidates are fabricated into diverse forms with major strategies. Ultimately, we try to define a new concept as a bioelectricity-coupling patch that provides a favorable cardiac micro-environment for cardiac functional activities. Underlying challenges and prospects are presented regarding industrial processing and cardiovascular treatment of conductive patch progress. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Cardiovascular Diseasebioelectricity-coupling patch, conductive biomaterials, myocardial repair, tissue engineering | INTRODUCTIONCardiovascular disease (CVD) poses a widespread threat to major morbidity and mortality, resulting in immense health and financial burden. According to the updated statistics, exposure to CVD poses life-threatening impacts on living quality at the level of 17.9 million death each year (Virani et al., 2021). Ischemic heart disease (IHD), especially myocardial infarction (MI), arouses significant concerns as a commonly devastating pattern of CVD (Tang et al., 2018). The

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Cardiac mechanostructure: Using mechanics and anisotropy as inspiration for developing epicardial therapies in treating myocardial infarction

Cited by 33 publications

References 258 publications

Tunable biomaterials for myocardial tissue regeneration: promising new strategies for advanced biointerface control and improved therapeutic outcomes

Tunable biomaterials for myocardial tissue regeneration: promising new strategies for advanced biointerface control and improved therapeutic outcomes

Integrated Perspective of Scaffold Designing and Multiscale Mechanics in Cardiac Bioengineering

Bioelectricity‐coupling patches for repairing impaired myocardium

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