Cardiac metabolic remodelling in chronic kidney disease

Comparative efficacy of exercise modalities for cardiopulmonary function in hemodialysis patients: A systematic review and network meta-analysis

“…Although hemodialysis is a widespread and well-established treatment to prolong patient survival, the reduction of aerobic capacity, imbalance of the body ( 2 ), muscle mass ( 3 ), and exercise endurance lead to a lack of physical activity in patients, resulting in decreased quality of life and mobility ( 4 , 5 ). Evidence suggests that peak oxygen uptake (VO 2 Peak) during cardiopulmonary exercise testing decreases significantly in patients with kidney disease as the disease progresses and that the causes of impaired cardiopulmonary function are diverse and include anemia ( 6 , 7 ), neuropathy ( 8 ), and cardiac and vascular dysfunction ( 9 ). Therefore, the objective of hemodialysis has shifted from maintaining the basic survival and prolonging the lives of patients to improving the quality of life and promoting patients' return to society ( 10 – 12 ).…”

Nonischemic Cardiomyopathy With Myocardial Calcinosis Masquerading as Cardiac Amyloidosis

“…[2][3][4][5][6] Our patient had elevated ionized calcium and parathyroid hormone levels before presentation, potentially mediating his unique presentation and decline. 1 Importantly, our case describes a patient whose CMR and 99m Tc-PYP findings were strongly suggestive of CA, highlighting a rare example of a false positive CMR and 99m Tc-PYP. Meta-analyses have estimated 99m Tc-PYP is 92.2% sensitive and 95.4% specific for diagnosing transthyretin CA.…”

“…Hyperparathyroidism and abnormal calcium homeostasis are implicated in metastatic calcification in chronic kidney disease, although the mechanisms remain under investigation. 1,2,4 Autopsy studies demonstrate parathyroid hyperplasia associated with myocardial calcification. [2][3][4][5][6] Our patient had elevated ionized calcium and parathyroid hormone levels before presentation, potentially mediating his unique presentation and decline.…”

Heart involvement in Fabry disease: clinical features, cardiac MRI and speckle-tracking echocardiography

“…Уремическая кардиомиопатия наблюдается более чем у 75% пациентов с ХБП и характеризуется гипертрофией и фиброзом миокарда, которые нарастают по мере ухудшения функции почек и сопровождаются увеличением риска смерти от сердечно-сосудистых причин, в том числе внезапной. Причины гипертрофии ЛЖ при ХБП включают в себя артериальную гипертонию, анемию, увеличение активности нейрогуморальных систем, накопление уремических токсинов и другие факторы [27]. В исследованной нами когорте у 2/3 больных с выраженной гипертрофией ЛЖ имелась терминальная стадия ХБП.…”

“…Медиана возраста пациентов составила 34,5 лет (27,5;45,0). Мужчины были несколько моложе женщин, однако разница медианы возраста у пациентов разного пола была статистически незначимой: 34,5 (27,5;45,0) и 37,0 (29,0;50,0) лет, соответственно (р=0,06). Медиана индекса ММЛЖ у мужчин достоверно превышала таковую у женщин: 78,0 и 61,0 г/м 2 , соответственно (р<0,01).…”