Cardiac metastasis from colorectal cancer: To be or not to be…

Pontillo, Daniele; Zampi, Giordano; Pergolini, Amedeo; Polizzi, Vincenzo; Tinti, Denitza; Spadaccia, P

doi:10.1016/j.repc.2014.02.022

Cited by 6 publications

(10 citation statements)

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“…In addition, it is difficult to detect a small cavity in the abdomen due to the complex anatomy of the cardia region with an irregular cavity shape. 24 , 25 It delays the diagnosis of CA, making the targeted treatment of CA difficult. Thus, the targeted treatment of CA demands urgent investigation.…”

Section: Discussionmentioning

confidence: 99%

NCAPG Induces Cell Proliferation in Cardia Adenocarcinoma via PI3K/AKT Signaling Pathway

Zhang

Wang

Han

et al. 2020

OTT

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Section: Discussionmentioning

confidence: 99%

NCAPG Induces Cell Proliferation in Cardia Adenocarcinoma via PI3K/AKT Signaling Pathway

Zhang

Wang

Han

et al. 2020

OTT

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“…Since cardiac cancer was easily confused with peptic ulcer, and symptomatic treatment could generally relieve its clinical manifestations, crowds of cardiac cancer patients refused to receive further examinations. In addition, the complex anatomy of cardiac area enabled the cavity shape to be irregular, making it tough to detect small concavities of abdomen . Thus, confirmed diagnoses of cardiac cancer were prone to be delayed, and pointed treatment for cardiac cancer became intractable.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, the complex anatomy of cardiac area enabled the cavity shape to be irregular, making it tough to detect small concavities of abdomen. 29,30 Thus, confirmed diagnoses of cardiac cancer were prone to be delayed, and pointed treatment for cardiac cancer became intractable. Furthermore, although chemo-/radiotherapies have been developed for improving survival of cardiac cancer patients, the patients gradually displayed an enhancive resistance to the therapies, which were assumed as facilitated metastasis and relapse of neoplasms.…”

Section: Discussionmentioning

confidence: 99%

LncRNA H19 interacted with miR‐130a‐3p and miR‐17‐5p to modify radio‐resistance and chemo‐sensitivity of cardiac carcinoma cells

Jia

Zhang²,

Zhan

et al. 2019

Cancer Medicine

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The current investigation explored the synthetic contribution of lncRNA H19, miR‐130a‐3p, and miR‐17‐5p to radio‐resistance and chemo‐sensitivity of cardiac cancer cells. Totally 284 human cardiac cancer tissues were gathered, and they have been pathologically diagnosed. The cardiac cancer cells were isolated with utilization of the mechanic method. Moreover, cisplatin, adriamycin, mitomycin, and 5‐fluorouracil were designated as the chemotherapies, and single‐dose X‐rays were managed as the radiotherapy for cardiac cancer cells. We also performed luciferase reporter gene assay to verify the targeted relationship between H19 and miR‐130a‐3p, as well as between H19 and miR‐17‐5p. Finally, mice models were established to examine the functions of H19, miR‐130a‐3p, and miR‐17‐5p on the development of cardiac cancer. The study results indicated that H19, miR‐130a‐3p, and miR‐17‐5p expressions within cardiac cancer tissues were significantly beyond those within adjacent nontumor tissues (P < 0.05), and H19 expression was positively correlated with both miR‐130a‐3p (rs = 0.43) and miR‐17‐5p (rs = 0.49) expressions. The half maximal inhibitory concentrations (IC50) of cisplatin, adriamycin, mitomycin, and 5‐fluorouracil for cardiac cancer cells were, respectively, determined as 2.01 μg/mL, 8.35 μg/mL, 24.44 μg/mL, and 166.42 μg/mL. The overexpressed H19, miR‐130a‐3p, and miR‐17‐5p appeared to improve the survival rate and viability of cardiac cancer cells that were exposed to chemotherapies and X‐rays (all P < 0.05). It was also drawn from luciferase reporter gene assay that H19 could directly target miR‐130a‐3p and miR‐17‐5p, thereby modifying the sensitivity of cardiac cancer cells to drugs and X‐rays (P < 0.05). Finally, the mice models also produced larger tumor size and higher tumor weight, when H19, miR‐130a‐3p, or miR‐17‐5p expressions were up‐regulated within them (P < 0.05). In conclusion, H19 could act on miR‐130a‐3p or miR‐17‐5p to alter the radio‐ and chemo‐sensitivities of cardiac cancer cells, helping to improve the radio‐/chemotherapies for cardiac cancer.

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“…She was also noted to be having peritoneal carcinomatosis and was treated with standard medical therapy. No specific names or duration of treatment was mentioned [ 7 ]. Meanwhile the case reported by Tsuji involved an incidentally diagnosed RV tumor with colonoscopy confirming wild type KRAS on histopathological examination.…”

Section: Discussionmentioning

confidence: 99%

Metastatic colorectal carcinoma to the right atrium: a case report and review of the literature

et al. 2021

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Background Cardiac metastasis due to colon cancer is extraordinarily uncommon. Given the rarity of diagnosis, there is paucity of evidence and hence, no established guidelines for evaluation or clinical management strategy. Clinical presentation We present the case of a 59 year old male with a previously treated colonic carcinoma who presented with new onset exertional dyspnea. He was noted to be having a right atrial mass on an echocardiogram performed at his cardiologist’s office. Further workup with CT angiogram of the chest confirmed a right atrial mass measuring 4.0 cm. Serum CEA was normal. Biopsies of the right atrial mass demonstrated metastatic moderately differentiated colonic adenocarcinoma. Mismatch repair protein expression analysis by immunohistochemistry showed no loss of MLH1, MSH2, MSH6 or PMS2 expression. Next generation sequencing for RAS and BRAF mutations was negative. Patient received treatment with FOLFIRINOX/ bevacizumab with noted reduction in size of mass. Conclusion To the best of our knowledge, this is the first report of next generation sequencing results available on a biopsy of metastatic colorectal cancer to the heart with the largest literature review of 31 reported cases of metastatic colorectal cancer to the heart. It will help direct clinical management and also adds evidence to the potential efficacy of treatment of this rare aggressive disease with chemotherapy in combination with VEGF inhibitors.

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Cardiac metastasis from colorectal cancer: To be or not to be…

Cited by 6 publications

References 0 publications

<p><em>NCAPG</em> Induces Cell Proliferation in Cardia Adenocarcinoma via PI3K/AKT Signaling Pathway</p>

<p><em>NCAPG</em> Induces Cell Proliferation in Cardia Adenocarcinoma via PI3K/AKT Signaling Pathway</p>

LncRNA H19 interacted with miR‐130a‐3p and miR‐17‐5p to modify radio‐resistance and chemo‐sensitivity of cardiac carcinoma cells

Metastatic colorectal carcinoma to the right atrium: a case report and review of the literature

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