Cardiac metastasis of tongue squamous cell carcinoma complicated by pulmonary embolism

Malekzadeh, Sonaz; Platon, Alexandra; Poletti, Pierre–Alexandre

doi:10.1097/md.0000000000007462

Cited by 10 publications

(6 citation statements)

References 16 publications

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“…18 When diagnosed ante-mortem, patients may present with nonspecific cardiac symptoms such as chest pain, shortness of breath, and palpitations. 19 In this systematic review, patients commonly demonstrated nonspecific cardiac symptoms such as chest pain, shortness of breath, syncope, and weight loss. Of these symptoms, chest pain and shortness of breath were the most prevalent (29.0% of cases), followed by syncope, then weight loss.…”

Section: Discussionmentioning

confidence: 99%

Systematic Review: Cardiac Metastasis of Lingual Squamous Cell Carcinoma

Kerndt

Nessel

Bills

et al. 2021

Spartan Medical Research Journal

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From this review, a total of 28 studies met inclusion criteria and received an OCEBM Level 4 evidence designation. Thirty-one patients were identified with cardiac metastasis from LSCC. Shortness of breath (29.0%) and chest pain (29.0%) were the most common presenting symptoms, and pericardial effusion (29.2%) and right ventricular outflow tract obstruction (25.0%) were the predominant echocardiogram findings. Cardiac metastases most often presented in the right ventricle (56.7%), followed by the left ventricle (43.3%). Palliative intervention (68.2%) or chemotherapy (40.9%) were typically implemented as treatments. All sample patients expired within one year of metastatic cancer diagnosis in cases that reported mortality outcomes. CONCLUSIONSPatients presenting with shortness of breath, tachycardia, and a history of squamous cell carcinoma of the tongue may indicate evaluation for LSCC cardiac metastasis. Although LSCC cardiac metastases typically favor the right and left ventricles, they are not exclusive to these sites. Palliative care may be indicated as treatment due to high mortality and overall poor outcomes from current interventions.

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Section: Discussionmentioning

confidence: 99%

Systematic Review: Cardiac Metastasis of Lingual Squamous Cell Carcinoma

Kerndt

Nessel

Bills

et al. 2021

Spartan Medical Research Journal

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“…With ECG changes being nonspecific, radiologic imaging like CT chest and cardiac MRI are relevant and have better precision. Echocardiography may be useful in assessing the functional impairment associated with the mass …”

Section: Discussionmentioning

confidence: 99%

“…Head and neck cancers with cardiac metastasis are very rare and are uniformly fatal, with a maximum reported survival of 3 months . Here we present a case of a patient with cardiac metastasis from soft palate primary disease who has survived for more than 18 months.…”

mentioning

confidence: 95%

Survival After Cardiac Metastasis in Malignant Disease of the Head and Neck

Mathew

Kannan

Menon

et al. 2019

JAMA Otolaryngol Head Neck Surg

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“…The incidence of cardiac metastases is substantially higher in malignancies from other sites such as melanoma, lung, breast, esophagus, and lymphomas. Local recurrences are more common for head and neck tumors, however, when distant metastases occur, they often involve the lung, skin, liver or bone [1,2]. Due to the nonspecific symptoms associated with cardiac metastases, they are often not detected until an advanced stage or at autopsy; thus, the reported incidence has varied widely in the literature from 0.2% to 11.8% [1,3].…”

Section: Introductionmentioning

confidence: 99%

Tonsillar carcinoma as a rare cause of cardiac metastases

Mark-Adjeli

Cirrone²,

Gupta

et al. 2019

Journal of Community Hospital Internal Medicine Perspectives

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Tonsillar carcinoma metastasis to the myocardium is undermined with detection rate often occurring at autopsy or advance stage. A 60-year-old male with a 1-month history of right-sided facial pain and failed antibiotics therapy underwent head and neck CT scan that revealed a tonsillar mass. Tonsillar biopsy revealed squamous cell carcinoma, HPV-16 positive. PET-CT scan showed a significant activity in the right tonsillar mass along with prominent right level 2 lymph nodes and no distant disease. Definite surgery was deferred and he underwent 7 weeks of radiation therapy with concurrent weekly Cisplatin. PET scan 8 weeks later showed significant improvement in large right palatine tonsil mass; however, a new FDG-avid cardiac mass of right ventricle. An echocardiogram showed an ejection fraction of 59% and a large mass in the apical portion of the right ventricle. Cardiac MRI confirmed a 9 cm right ventricular mass. Complete resection of the cardiac mass was unsuccessful; a partial tumor debulking provided adequate sample for pathologic examination, which was consistent with metastatic squamous cell cancer, p16+, clinical-stage T4aN1M1. Surgical intervention was not performed; instead, he received a palliative radiation therapy to his right-sided cardiac mass with concurrent Keytruda immunotherapy. Unfortunately, the evening of successfully completing his last therapy, he was found unresponsive and subsequently expired. Although tonsillar carcinoma metastasis to the myocardium is rarely coupled with its atypical presentations, clinicians should consider early echocardiogram evaluation for possible metastatic disease so as to provide early interventions.

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Cardiac metastasis of tongue squamous cell carcinoma complicated by pulmonary embolism

Cited by 10 publications

References 16 publications

Systematic Review: Cardiac Metastasis of Lingual Squamous Cell Carcinoma

Systematic Review: Cardiac Metastasis of Lingual Squamous Cell Carcinoma

Survival After Cardiac Metastasis in Malignant Disease of the Head and Neck

Tonsillar carcinoma as a rare cause of cardiac metastases

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