2002
DOI: 10.1161/01.res.0000031957.70034.89
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Cardiac Microstructure

Abstract: Abstract-Our understanding of the electrophysiological properties of the heart is incomplete. We have investigated two issues that are fundamental to advancing that understanding. First, there has been widespread debate over the mechanisms by which an externally applied shock can influence a sufficient volume of heart tissue to terminate cardiac fibrillation. Second, it has been uncertain whether cardiac tissue should be viewed as an electrically orthotropic structure, or whether its electrical properties are,… Show more

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Cited by 223 publications
(56 citation statements)
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References 35 publications
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“…The myofibre architecture of the left ventricle observed in the ovine model reported in this study and others is consistent with histological and ultrastructural studies of human hearts [3], [5], [29], [30]. We hypothesize that the orientation of mid-wall and epicardial fibres may play a role in coordinating the transmural pattern of propagation observed in the absence of purkinje activation.…”
Section: Discussionsupporting
confidence: 90%
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“…The myofibre architecture of the left ventricle observed in the ovine model reported in this study and others is consistent with histological and ultrastructural studies of human hearts [3], [5], [29], [30]. We hypothesize that the orientation of mid-wall and epicardial fibres may play a role in coordinating the transmural pattern of propagation observed in the absence of purkinje activation.…”
Section: Discussionsupporting
confidence: 90%
“…The reason for this is beyond the scope of this study, yet represents an important factor to consider during clinical voltage mapping procedures using unipolar electrogram recordings. Possible explanations relating to attenuation of unipolar V -P include conductivity changes associated with tissue anisotropy and effects relating to bifurcation of conduction [3], [5], [12]. These effects have not been previously investigated in large volume conductors beyond the millimetre scale.…”
Section: Discussionmentioning
confidence: 99%
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“…A different approach to geometrical modelling and finite-element discretization was initiated by Hooks et al (2002), who modelled a small transmural slab (0.8! 0.8!3.7 mm 3 ) of the rat left ventricle.…”
Section: Discretization Methodsmentioning
confidence: 99%
“…27,33,[69][70][71] Conductivity values along and across bres are indirectly determined to yield conduction velocities, as measured experimentally in tissue. 72 …”
Section: Whole Organ Heart Modelsmentioning
confidence: 99%