Cardiac MRI findings of endomyocardial fibrosis (Loeffler’s endocarditis) in a patient with rheumatoid arthritis

Kharabish, Ahmed; Haroun, Dina

doi:10.1016/j.jsha.2014.11.002

Cited by 16 publications

(8 citation statements)

References 16 publications

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“…There are numerous case reports of patients with hypereosinophilic syndrome who also suffer from an autoimmune disease including ulcerative colitis, autoimmune hepatitis, autoimmune thyroiditis, multiple sclerosis, systemic lupus erythematosus, antiphospholipid syndrome, myasthenia gravis, and rheumatoid arthritis ( 295 – 310 ). Some of these patients had more than one autoimmune disease.…”

Section: Autoimmune Diseases In Patients With Eosinophil-associated Dmentioning

confidence: 99%

Eosinophils in Autoimmune Diseases

2017

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Eosinophils are multifunctional granulocytes that contribute to initiation and modulation of inflammation. Their role in asthma and parasitic infections has long been recognized. Growing evidence now reveals a role for eosinophils in autoimmune diseases. In this review, we summarize the function of eosinophils in inflammatory bowel diseases, neuromyelitis optica, bullous pemphigoid, autoimmune myocarditis, primary biliary cirrhosis, eosinophilic granulomatosis with polyangiitis, and other autoimmune diseases. Clinical studies, eosinophil-targeted therapies, and experimental models have contributed to our understanding of the regulation and function of eosinophils in these diseases. By examining the role of eosinophils in autoimmune diseases of different organs, we can identify common pathogenic mechanisms. These include degranulation of cytotoxic granule proteins, induction of antibody-dependent cell-mediated cytotoxicity, release of proteases degrading extracellular matrix, immune modulation through cytokines, antigen presentation, and prothrombotic functions. The association of eosinophilic diseases with autoimmune diseases is also examined, showing a possible increase in autoimmune diseases in patients with eosinophilic esophagitis, hypereosinophilic syndrome, and non-allergic asthma. Finally, we summarize key future research needs.

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Section: Autoimmune Diseases In Patients With Eosinophil-associated Dmentioning

confidence: 99%

Eosinophils in Autoimmune Diseases

2017

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“…Biopsy also comes with inherent sampling error which affects diagnostic sensitivity. Diagnosis purely on the basis of CMRI findings without endomyocardial biopsy has been reported in patients, and CMRI was able to exclude myocarditis and coronary artery disease [10 , 15 , 20] . CMRI is also a promising modality to follow-up patients to assess response to therapy, as it enables the comparison of serial images [16 , 18] .…”

Section: Discussionmentioning

confidence: 98%

Right sided heart failure secondary to hypereosinophilic cardiomyopathy – clinical manifestation and diagnostic pathway

Ramtoola

Shahzad

Okonkwo

et al. 2020

Radiology Case Reports

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Hypereosinophilic cardiomyopathy is a rare restrictive cardiomyopathy which often presents with left-sided heart failure. We present an interesting case of a 58-year-old male patient with known hypereosinophillic syndrome who had presented with congestive cardiac failure with predominant features of right-sided volume overload. Cardiac magnetic resonance imaging confirmed the diagnosis by demonstrating obliteration of the right ventricular apex and endocardial-delayed gadolinium enhancement at the mid-septal and inferior segment, at both the right ventricular and left ventricular apical region, consistent with fibrosis. He was successfully treated with intravenous diuretics to good effect. This case report demonstrates a rare clinical presentation of right ventricle involvement in hypereosinophilic cardiomyopathy and the current pathway for diagnosis with the favoured emergence of cardiac magnetic resonance imaging. All patients with hypereosinophilic syndrome should be closely monitored for signs of cardiac involvement, as early treatment carries a better prognosis.

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“…La resonancia desempeña un papel en el diagnóstico y el pronóstico, pues proporciona una evaluación morfológica precisa, con características restrictivas típicas de ventrículos pequeños o no dilatados, con elementos de hipertrofia apical. También hay un aumento típico de la aurícula por la grave disfunción diastólica, con patrón restrictivo y realce subendocárdico que se extiende desde la región subvalvular a los ápices de los dos ventrículos; los trombos se describen con frecuencia 21 . Salemi, et al 22 publicaron un interesante estudio de resonancia con confirmación histológica de fibrosis endomiocárdica.…”

Section: Discussionunclassified

Fibrosis endomiocárdica: una revisión actualizada a propósito de unos casos en un programa de falla cardiaca

Ramírez-Ramos¹,

Gallego²,

Fajardo³

et al. 2022

RCCAR

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son poco comprendidas. Para su diagnóstico se deben tener en cuenta los datos del paciente, el cuadro clínico y los hallazgos ecocardiográficos. Presentamos los casos confirmados en un centro de referencia cardiovascular. Descripción de los casos: Se han documentado tres casos, de los cuales dos son mujeres. Todos debutaron con un cuadro insidioso de disnea con esfuerzo. Los hallazgos ecocardiográficos fueron disfunción diastólica con patrón restrictivo, insuficiencia moderada de válvulas auriculoventriculares e hipertensión pulmonar; en dos casos se encontraron imágenes anormales endocárdicas en el ventrículo izquierdo y se realizó biopsia endomiocárdica para confirmar el diagnóstico. Ninguno mejoró la clase funcional ni la frecuencia de hospitalizaciones. Conclusiones: La fibrosis endomiocárdica debe considerarse en todo paciente con falla cardiaca con un patrón restrictivo asociado y con poca respuesta al manejo farmacológico convencional. Los pacientes presentados tenían hallazgos

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Cardiac MRI findings of endomyocardial fibrosis (Loeffler’s endocarditis) in a patient with rheumatoid arthritis

Cited by 16 publications

References 16 publications

Eosinophils in Autoimmune Diseases

Eosinophils in Autoimmune Diseases

Right sided heart failure secondary to hypereosinophilic cardiomyopathy – clinical manifestation and diagnostic pathway

Fibrosis endomiocárdica: una revisión actualizada a propósito de unos casos en un programa de falla cardiaca

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