Cardiac Mri in Cardiomyopathies

Lahoti, Nishant; Jabbour, Richard J.; Ariff, Ben; Wang, Brian

doi:10.2217/fca-2020-0233

Cited by 5 publications

(4 citation statements)

References 71 publications

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“…This resulted in an overestimation of LVEF of 6.6 ± 8.3% by echocardiography compared with CMR (echocardiographic LVEF: 31.5 ± 8.7% and CMR LVEF 24.9 ± 9.6%) [30]. Similar findings were reported in a 2022 review by Lahoti et al, which estimated the mean difference in LVEF measurement between echo and CMR to be 4%, with LVEF as measured by CMR being more predictive of mortality [31].…”

Section: Mri and Other Imaging Modalities In The Evaluation Of Lvefsupporting

confidence: 68%

“…HF is caused by a loss of functional myocardial cells after injury to the heart from various causes. The most common etiologies are broadly classified as ischemic or non-ischemic cardiomyopathies [31]. According to epidemiological studies and large-scale treatment trials, patients with ischemic HF have a worse prognosis than those with non-ischemic etiologies.…”

Section: Cmr In Cardiomyopathiesmentioning

confidence: 99%

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Cardiovascular Magnetic Resonance Imaging: A Prospective Modality in the Diagnosis and Prognostication of Heart Failure

Elmadi¹,

Kumar²,

Pugalenthi³

et al. 2022

Cureus

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Heart failure (HF) is a clinical syndrome resulting from structural cardiac remodeling and altered function that impairs tissue perfusion. This article aimed to highlight the current diagnostic and prognostic value of cardiac magnetic resonance (CMR) in the management of HF and prospective future applications. Reviewed are the physics associated with CMR, its use in ischemic and non-ischemic causes of HF, and its role in quantifying left ventricular ejection fraction. It also emphasized that CMR allows for noninvasive morphologic and functional assessment, tissue characterization, blood flow, and perfusion evaluation in patients with suspected or diagnosed HF. CMR has become a crucial instrument for the diagnosis, prognosis, and therapy planning in patients with HF and cardiomyopathy due to its accuracy in quantifying cardiac volumes and ejection fraction (considered the gold standard) as well as native and post-contrast myocardial tissue characterization.

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Section: Mri and Other Imaging Modalities In The Evaluation Of Lvefsupporting

confidence: 68%

Section: Cmr In Cardiomyopathiesmentioning

confidence: 99%

Cardiovascular Magnetic Resonance Imaging: A Prospective Modality in the Diagnosis and Prognostication of Heart Failure

Elmadi¹,

Kumar²,

Pugalenthi³

et al. 2022

Cureus

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“…In addition, it is possible to derive multiple types of functional information. Cardiovascular MRI of the heart is used to determine endsystolic-, enddiastolic volumes, stroke volume, ejection fraction and multiple other parameters ( 120 ). Brain activity is associated with changes in blood flow and the amount of oxy- and desoxyhemoglobin and these parameters are used by functional MRI (fMRI) to gain information about brain activity ( 121 ).…”

Section: Imaging the Consequences Of Impaired Oxygen Delivery By Mrimentioning

confidence: 99%

A Toolbox to Investigate the Impact of Impaired Oxygen Delivery in Experimental Disease Models

et al. 2022

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Impaired oxygen utilization is the underlying pathophysiological process in different shock states. Clinically most important are septic and hemorrhagic shock, which comprise more than 75% of all clinical cases of shock. Both forms lead to severe dysfunction of the microcirculation and the mitochondria that can cause or further aggravate tissue damage and inflammation. However, the detailed mechanisms of acute and long-term effects of impaired oxygen utilization are still elusive. Importantly, a defective oxygen exploitation can impact multiple organs simultaneously and organ damage can be aggravated due to intense organ cross-talk or the presence of a systemic inflammatory response. Complexity is further increased through a large heterogeneity in the human population, differences in genetics, age and gender, comorbidities or disease history. To gain a deeper understanding of the principles, mechanisms, interconnections and consequences of impaired oxygen delivery and utilization, interdisciplinary preclinical as well as clinical research is required. In this review, we provide a “tool-box” that covers widely used animal disease models for septic and hemorrhagic shock and methods to determine the structure and function of the microcirculation as well as mitochondrial function. Furthermore, we suggest magnetic resonance imaging as a multimodal imaging platform to noninvasively assess the consequences of impaired oxygen delivery on organ function, cell metabolism, alterations in tissue textures or inflammation. Combining structural and functional analyses of oxygen delivery and utilization in animal models with additional data obtained by multiparametric MRI-based techniques can help to unravel mechanisms underlying immediate effects as well as long-term consequences of impaired oxygen delivery on multiple organs and may narrow the gap between experimental preclinical research and the human patient.

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“…Endomyocardial biopsy (EMB) remains the gold standard for diagnostic confirmation of inflammatory cardiomyopathy. Cardiac magnetic resonance imaging (CMR) is the non-invasive gold standard, which may also be used to identify affected myocardial regions for EMB ( 8 ). The availability of both methods is limited due to infrastructure and expertise concerns across medical institutions.…”

Section: Introductionmentioning

confidence: 99%

Case report: Recurrence of inflammatory cardiomyopathy detected by magnetocardiography

Suwalski,

Golpour,

Musigk

et al. 2023

Front. Cardiovasc. Med.

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BackgroundThe diagnosis of inflammatory cardiomyopathies remains challenging. Life-threatening conditions such as acute coronary syndrome (ACS) always have to be considered as differential diagnoses due to similarities in presentation. Diagnostic methods for inflammatory cardiomyopathy include endomyocardial biopsy (EMB), cardiac magnetic resonance imaging (CMR), and positron emission tomography-computed tomography (PET-CT). We report a case in whom magnetocardiography (MCG) led to an initial diagnosis of inflammatory cardiomyopathy and in whom MCG was used for subsequent monitoring of treatment response under immunosuppression.Case presentationA 53-year-old man presented with two recurrent episodes of inflammatory cardiomyopathy within a 2-year period. The patient initially presented with reduced exercise capacity. Echocardiography revealed a moderately reduced left ventricular ejection fraction (LVEF 40%). Coronary angiography ruled out obstructive coronary artery disease (CAD) and an EMB was performed. The EMB revealed inflammatory cardiomyopathy without viral pathogens or replication. Moreover, we performed MCG, which confirmed a pathological Tbeg-Tmax vector of 0.108. We recently established a cutoff value of Tbeg-Tmax of 0.051 or greater for the diagnosis of inflammatory cardiomyopathy. Immunosuppressive therapy with prednisolone was initiated, resulting in clinical improvement and an LVEF increase from 40% to 45% within 1 month. Furthermore, the MCG vector improved to 0.036, which is considered normal based on our previous findings. The patient remained clinically stable for 23 months. During a routine follow-up, MCG revealed an abnormal Tbeg-Tmax vector of 0.069. The patient underwent additional testing including routine laboratory values, echocardiography (LVEF 35%), and PET-CT. PET-CT revealed increased metabolism in the myocardium—primarily in the lateral wall. Therapy with prednisolone and azathioprine was initiated and MCG was used to monitor the effect of immunosuppressive therapy.ConclusionIn addition to diagnostic screening, MCG has the potential to become a valuable method for surveillance monitoring of patients who have completed treatment for inflammatory cardiomyopathy. Furthermore, it could be used for treatment monitoring. While changes in the magnetic vector of the heart are not specific to inflammatory cardiomyopathy, as they may also occur in other types of cardiomyopathies, MCG offers a tool of broad and efficient diagnostic screening for cardiac pathologies without side effects.

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Cardiac Mri in Cardiomyopathies

Cited by 5 publications

References 71 publications

Cardiovascular Magnetic Resonance Imaging: A Prospective Modality in the Diagnosis and Prognostication of Heart Failure

Cardiovascular Magnetic Resonance Imaging: A Prospective Modality in the Diagnosis and Prognostication of Heart Failure

A Toolbox to Investigate the Impact of Impaired Oxygen Delivery in Experimental Disease Models

Case report: Recurrence of inflammatory cardiomyopathy detected by magnetocardiography

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