Cardiac operations in patients with low-grade small lymphocytic malignancies

Ghosh, Piyali; Carroll, Ian A.; Kanhere, Apoorva; Ng, Bernice; Larbalestier, Robert; Edwards, Mark

doi:10.1016/s0022-5223(99)70098-x

Cited by 15 publications

(10 citation statements)

References 15 publications

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“…White blood cell count generally increases after open-heart surgery, and CPB may stimulate a leucomoid reaction, which can lead to a relapse in an otherwise quiescent illness 6,7. In our study, white blood cell count increased between acceptable ranges, as seen in Table 1.…”

Section: Discussionsupporting

confidence: 59%

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Can cardiac surgery be performed safely on patients with haematological malignancies

Güler

Şahin

Cingoz

et al. 2012

Cardiovascular Journal of Africa

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IntroductionSurgical strategy in patients with haematological malignancies must be planned and carried out with the specific aim of decreasing postoperative complications. The aim of this study was to present our experience on patients previously diagnosed with haematological malignancies who subsequently underwent cardiac surgery. We include data to assist other surgeons predict factors affecting postoperative morbidity and mortality in this group of patients.MethodsFifteen patients diagnosed with haematological malignancies who had cardiac surgery were retrospectively analysed. Eight patients had chronic lymphocytic leukaemia, six had non-Hodgkin’s lymphoma and the rest had chronic myelocytic leukaemia. Coronary artery bypass graft surgery was performed on all of them.ResultsThere were no hospital mortalities. The average follow-up period was 35 ± 11 (23–56) months. Three patients required early postoperative re-operation because of excessive bleeding. No mortalities were seen in the early postoperative period. There were five (33%) deaths during the late follow-up period. Three patients were lost due to intracranial bleeding (confirmed by autopsy) in the 16th, 23rd and 38th months after surgery. The remaining two patients had sudden death in the eighth and 55th months from non-detectable causes.ConclusionConclusion: Cardiac surgery can be performed with acceptable early postoperative outcomes in patients with haematological malignancies. Intracranial bleeding is an important factor contributing to late mortality and patient selection and risk stratification are crucial to improving surgical benefits.

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Section: Discussionsupporting

confidence: 59%

“…CPB, which aggravates cell damage, also has immune-depressant properties, resulting in an increased incidence of infection 6,7. Furthermore, haematological malignancies may lead to antibody deficiency, leucopenia or impaired T-cell function.…”

Section: Discussionmentioning

confidence: 99%

Can cardiac surgery be performed safely on patients with haematological malignancies

Güler

Şahin

Cingoz

et al. 2012

Cardiovascular Journal of Africa

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“…Recently, several reports suggested that patients with concomitant malignant neoplastic disease, OPCAB surgery has better outcomes and lowered operative mortality because of spared platelet function, less blood loss, and avoidance of infection. [7][8][9] Other than the abovementioned points, a unique situation exists in patients with a brain tumor. Application offpump bypass to these patients is of paramount importance because cardiopulmonary bypass causes tissue edema and consequently increased compression effect of the tumor.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, several reports suggested that patients with concomitant malignant neoplastic disease, the OPCAB surgery has better outcomes and lowered operative mortality because of spared platelet function, less blood loss, and avoidance of infection. [7][8][9] Other than patients having solitary cancer, patients with a low-grade lymphocytic malignancy (including some types of non-Hodgkin's lymphoma and chronic lymphocytic leukemia) can be referred for coronary bypass surgery if a long-term survival is expected.…”

mentioning

confidence: 99%

Off-Pump Coronary Bypass for Patients With Concomitant Malignancy

Nurozler¹,

Kutlu²,

Kucuk³

2006

Circ J

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“…The majority had coronary artery bypass surgery as well as valvular replacement. Previous studies, showed that cardiac surgery can be performed but carries a high incidence of mortality and morbidity [5][6][7][8][9][10][11] .…”

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confidence: 99%

Hematological malignancies: A real challenge to cardiac surgeons

Darwazah¹

2012

J Hemat Malig

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Hematological Malignancies are a group of diseases including various types of leukemia, lymphoma and myeloma. They are characterized by affection of both the lymphatic and hematopoietic systems, as a result they cause immune defects, platelets dysfunction, and hypercoagulability syndrome .These immunocompromised patients are prone to develop various complications including infection, disease transformation, autoimmune complications and increase liability to develop another malignancy.

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Cardiac operations in patients with low-grade small lymphocytic malignancies

Cited by 15 publications

References 15 publications

Can cardiac surgery be performed safely on patients with haematological malignancies

Can cardiac surgery be performed safely on patients with haematological malignancies

Off-Pump Coronary Bypass for Patients With Concomitant Malignancy

Hematological malignancies: A real challenge to cardiac surgeons

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