Cardiac Output Distribution in the Chick Embryo. 373

Mulder, Twan; Golde, Jolande C van; Prinzen, Frits W.; Straaten, H. W. M. van; Blanco, Carlos F

doi:10.1203/00006450-199604001-00393

Cited by 1 publication

(2 citation statements)

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“…[13] To perform locomotion in blood vessels, we incubated fertilized White Leghorn chicken eggs up to Hamburger and Hamilton (HH) embryonic stage 36, until they had relevant physiological blood circulation (Figure 7a). [17] In HH stage 36, having confirmed the vessel formation and physiological circulation via stereomicroscope (Movie S3, Supporting Information), we injected microrollers into the blood vessels of the chicken embryo with the help of a micropipette (Figure 7b, Supporting Information). It should be noted that the injection of microrollers into the vessel of the chicken embryo was highly challenging due to the following reasons: 1) The injection of microparticles is generally challenging due to dispersion problems in the needle.…”

Section: Microrollers On Biological Microtopographiesmentioning

confidence: 85%

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Size‐Dependent Locomotion Ability of Surface Microrollers on Physiologically Relevant Microtopographical Surfaces

Bozuyuk,

Yildiz,

Han

et al. 2023

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Controlled microrobotic navigation inside the body possesses significant potential for various biomedical engineering applications. Successful application requires considering imaging, control, and biocompatibility. Interaction with biological environments is also a crucial factor in ensuring safe application, but can also pose counterintuitive hydrodynamic barriers, limiting the use of microrobots. Surface rolling microrobots or surface microrollers is a robust microrobotic platform with significant potential for various applications; however, conventional spherical microrollers have limited locomotion ability over biological surfaces due to microtopography effects resulting from cell microtopography in the size range of 2–5 µm. Here, the impact of the microtopography effect on spherical microrollers of different sizes (5, 10, 25, and 50 µm) is investigated using computational fluid dynamics simulations and experiments. Simulations revealed that the microtopography effect becomes insignificant for increasing microroller sizes, such as 50 µm. Moreover, it is demonstrated that 50 µm microrollers exhibited smooth locomotion ability on in vitro cell layers and inside blood vessels of a chicken embryo model. These findings offer rational design principles for surface microrollers for their potential practical biomedical applications.

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Section: Microrollers On Biological Microtopographiesmentioning

confidence: 85%

“…Microrollers with a diameter of 50 μm were injected into the umbilical vein using a 30-gauge needle. [17]…”

Section: Methodsmentioning

confidence: 99%