Cardiac output

Pramanik, Debasis

doi:10.5005/jp/books/12674_32

Cited by 1 publication

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“…In addition, we excluded those with a heart rate of < 50 or > 150 beats/min, which could lead to a decrease in cardiac output, since our interest was to evaluate the role of heart rate as a compensatory mechanism in septic shock. 10 Finally, the eligible patients with septic shock were categorized into the tachycardia (heart rate > 100 beats/min) and non-tachycardia (heart rates ≤ 100 beats/min) groups based on the initial heart rate at the time of diagnosis of septic shock.…”

Section: Methodsmentioning

confidence: 99%

The Association Between Tachycardia and Mortality in Septic Shock Patients According to Serum Lactate Level: A Nationwide Multicenter Cohort Study

Na,

Oh,

Park

et al. 2023

J Korean Med Sci

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Background This study aimed to evaluate whether the effect of tachycardia varies according to the degree of tissue perfusion in septic shock. Methods Patients with septic shock admitted to the intensive care units were categorized into the tachycardia (heart rate > 100 beats/min) and non-tachycardia (≤ 100 beats/min) groups. The association of tachycardia with hospital mortality was evaluated in each subgroup with low and high lactate levels, which were identified through a subpopulation treatment effect pattern plot analysis. Results In overall patients, hospital mortality did not differ between the two groups (44.6% vs. 41.8%, P = 0.441), however, tachycardia was associated with reduced hospital mortality rates in patients with a lactate level ≥ 5.3 mmol/L (48.7% vs. 60.3%, P = 0.030; adjusted odds ratio [OR], 0.59, 95% confidence interval [CI], 0.35–0.99, P = 0.045), not in patients with a lactate level < 5.3 mmol/L (36.5% vs. 29.7%, P = 0.156; adjusted OR, 1.39, 95% CI, 0.82–2.35, P = 0.227). Conclusion In septic shock patients, the effect of tachycardia on hospital mortality differed by serum lactate level. Tachycardia was associated with better survival in patients with significantly elevated lactate levels.

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Section: Methodsmentioning

confidence: 99%